ELISA kits - № 100-21 OnkoEIA-CA 125
CA 125 is an oncofetal protein. It is a mucoglycoprotein with a molecular weight of over 200 000 Da. Normally in adults CA 125 exists in two forms: free and membrane-bound. Membrane-bound antigen can be identified on the surface of epithelial cells of fallopian tubes, cervix, endometrion, bronchi, mammary gland and sudoriferous gland. High concentrations of free form can be detected in seminal liquid, breast milk, vaginal secretions, saliva, bronchoalveolar and intraperitoneal liquids. In bloodstream CA 125 persists in low concentrations. Increased concentration of serum CA 125 is a sign of ovarian pathology (either benign or malignant).
Quantitative determination of serum CA 125 is used for monitoring of patients with ovarian cancer for estimation of treatment efficiency, early identification of recurrences and asymptomatic dissemination of residual tumor. Diagnostic value of method depends on histological type of tumor: it is the highest in the case of serous ovarian carcinomas in comparison with other types of carcinoma (e.g. mucinous carcinoma).
OncoEIA-CA 125 kit is intended for the quantitative determination of cancer antigen CA 125 in human serum.