Gustavo Raskosky
Superhydrophobic device to model tumor progression
20.09.2024
Rice University bioengineers have harnessed the lotus leaf's unique properties to create a cutting-edge platform for culturing cancer cell clusters. This system offers a new approach to studying tumor progression and metastasis, providing essential insights into cancer biology and treatment.
University of Rochester photo / J. Adam Fenster
Ultrasound promotes blood vessel growth in damaged tissue
19.09.2024
A team of researchers at the University of Rochester has developed a new approach using ultrasound technology to promote the growth of blood vessels in damaged tissue. The method could have significant applications in reconstructive and plastic surgeries, as well as wound healing.
From lab to market: How vessel-chips are changing drug testing
20.08.2024
As the medical field seeks more ethical and accurate alternatives to traditional drug testing, vessel-chip technology is a prospective solution. This technology promises greater accuracy and a reduced need for animal trials.
Wei Gao, California Institute of Technology
Smart bandages: Advancing chronic wound treatment
02.07.2024
A team of researchers from the Keck School of Medicine of USC and the California Institute of Technology (Caltech) is developing advanced electronic bandages and other tools to improve the monitoring and healing of chronic wounds. These wearable bioelectronic systems, tested in animal models, have the potential to enhance wound care through controlled drug release and electrical stimulation.
Jia Zhu/Penn State
Rewritable, recyclable ‘smart skin’ monitors biological signals on demand
06.06.2024
Penn State researchers have developed an adhesive sensing device that seamlessly attaches to human skin to detect and monitor health. The writable sensors can be removed with tape, allowing new sensors to be patterned onto the device.
Joe Carrotta for NYU Langone Health
Breakthrough transplant surgery: Heart pump and gene-edited pig kidney combined
21.05.2024
NYU Langone Health has achieved a medical milestone with the first-ever combined mechanical heart pump and gene-edited pig kidney transplant surgery.
Hannes Woidich/DWI – Leibniz-Institut für Interaktive Materialien
Sonopharmacology research: Andreas Herrmann awarded ERC Advanced Grant
14.05.2024
Professor Andreas Herrmann, a leading researcher at the DWI - Leibniz Institute for Interactive Materials, has been granted an ERC Advanced Grant totaling €2.5 million by the European Research Council (ERC). This funding will support his research into the use of biocompatible ultrasound for medical applications over the next five years.
IGTP
Cardiac bioimplants for heart attack treatment
13.05.2024
A recent study highlights the safety and effectiveness of PeriCord bioimplants, derived from umbilical cord stem cells, for regenerating heart tissue post-myocardial infarction.
Mikaël M. Martino
Unveiling the role of sensory neurons in tissue repair
10.05.2024
Research from Monash and Osaka Universities highlights the key role sensory neurons play in tissue repair and regeneration, marking a significant advancement for regenerative medicine.
Gao et al., 10.1038/s41467-024-46636-7
Bioelectronic mesh for cardiac tissue monitoring
30.04.2024
A team of engineers, led by the University of Massachusetts Amherst, has developed a cutting-edge bioelectronic mesh system integrated with graphene sensors to monitor both mechanical movement and electrical signals in lab-grown human cardiac tissue.
minkus-images.de/Fraunhofer IWS
Insights into the development of metastases with miniature laboratories
22.04.2024
New developments at the Fraunhofer Institute for Material and Beam Technology IWS and partners enable improved research possibilities for cancer therapy using microphysiological systems.
Michelle Bixby/Penn State
3D-printed skin technique potentially enhances reconstructive surgery
15.04.2024
A breakthrough in reconstructive surgery may be on the horizon, as researchers develop a 3D-printed skin that integrates hair follicle precursors, leveraging adipose tissue for more natural results.
TERM/UKW
The potential of nasal cartilage in knee joint treatment
05.04.2024
At the University Hospital Wuerzburg, a promising new treatment for knee joint defects involves the use of nasal cartilage, and it's edging closer to approval with significant EU funding. The new method is using autologous cartilage from the nasal septum, an approach that may seem as enchanting as the term "ENCANTO" implies.
UGRSKIN: artificial skin as a game-changer in burn treatment
11.03.2024
The University of Granada (UGR) has pioneered a solution for burn treatment with its artificial skin “UGRSKIN”. Developed by the Tissue Engineering Research Group, this advanced therapy medicinal product (ATMP) has improved the approach to treating severe burns, offering patients new hope and enhanced outcomes.
POSTECH
Tailored medical adhesives for personalized healing
26.02.2024
POSTECH researchers led by Prof. Hyung Joon Cha, alongside colleagues, introduced groundbreaking personalized underwater bio-adhesive patches (CUBAP) derived from mussel adhesive proteins. This discovery, featured in Advanced Materials, improves biomedical adhesives, offering tailored internal healing solutions.
Universität Bayreuth
Advanced 3D printing technology improves tissue engineering
19.02.2024
Advancements in 3D printing technology are improving tissue engineering, offering promising prospects for the artificial production of biological tissues. Researchers at the University of Bayreuth have developed a changing technique that combines hydrogels and fibers, opening new avenues for tissue fabrication.
Viscient Biosciences
Revolutionizing liver disease research with 3D bioprinted model
07.02.2024
Metabolic dysfunction-associated steatohepatitis (MASH), previously known as nonalcoholic steatohepatitis (NASH), is a liver disease characterized by inflammation and scarring, reaching epidemic proportions with an estimated 1.5 percent to 6.5 percent of U.S. adults affected.
Empa
Smart wound sealing with nanoparticles and light soldering
24.01.2024
Empa researchers have pioneered a novel soldering process that employs nanoparticles and lasers to gently fuse tissue, ushering in a new era in wound closure.
microgen
TissueGrinder: Improved cell analyses via enhanced-quality sample preparation
07.12.2023
A new method for examining tissue samples could change the way we diagnose and treat cancer. Researchers at the Max Planck and Fraunhofer IPA have developed an automated system based on the principle of enzyme-free tissue processing and the mechanical deformability of individual cells.
Peer Erfle/IMT
Microchips: better understand diseases like schizophrenia
15.09.2023
The European Research Council (ERC) has announced the recipients of its prestigious Starting Grants. Among them is a researcher from the Technical University of Braunschweig: Dr. Thomas Winkler will receive €1.5 million for his research on modular organ-on-chip technology to better understand neuropsychiatric disorders such as schizophrenia.
ETH Zürich / Bar-Nur Lab
Building muscle in the lab
23.08.2023
A new method allows large quantities of muscle stem cells to be safely obtained in cell culture.
Elisha Krieg und Yu-Hsuan Peng
Programmable DNA hydrogels for advanced cell culture and personalized medicine
22.08.2023
The team of Dr. Elisha Krieg at the Leibniz Institute of Polymer Research Dresden has developed a dynamic DNA-crosslinked matrix (DyNAtrix) by combining classical synthetic polymers with programmable DNA crosslinkers.
University of Nottingham
PeptiMatrix: Platform could replace use of animals in research
09.08.2023
PeptiMatrix is the latest spin-out company from the University of Nottingham, providing access to an innovative 3D cell culture platform that aims to replace the use of animals in research.
Patrick Mansell/Penn State
High-speed bioprinting of bones, tracheas, organs
28.07.2023
Developing technology to quickly and efficiently bioprint human tissues at scale is the goal of a new project led by Penn State researchers. When fully developed, the technology will be the first to enable the fabrication of scalable, native tissues such as bones, tracheas and organs.
Max-Planck-Institut für Polymerforschung
Jasmina Gačanin investigates living biomaterials
20.07.2023
Dr. Jasmina Gačanin, postdoctoral researcher at the Max Planck Institute for Polymer Research in the department of Prof. Dr. Tanja Weil, has been appointed as a “Peretti-Schmucker Fellow”.
mihacreative
Personalized cartilage replacement helps with knee pain
27.06.2023
Knee osteoarthritis is a widespread form of arthrosis that limits those affected in their everyday lives. The wear and tear in the cartilage tissue often causes pain and movement restrictions. In order to improve treatment, researchers have developed a process that allows artificial cartilage tissue to be individually tailored to sufferers.
Gregor Hübl / Universität Bonn
Researching organoids: two new Argelander Professors at the University of Bonn
21.06.2023
Two new assistant professors at the University of Bonn are setting out to develop “mini-organs” in order to study metabolic and disease mechanisms.
Fotogenia - Renate Trummer
Tissue Engineering: TU Graz revolutionises production of biocompatible microfibres
02.06.2023
Using a newly developed method for the efficient and cost-effective production of biocompatible microfibres, the production of autologous skin and organs can be significantly accelerated. Responsible for the development are Carole Planchette and her team from TU Graz.
Ella Marushchenko
Breaking through bacterial barriers in chronic treatment-resistant wounds
24.05.2023
Researchers in the UNC School of Medicine's Department of Microbiology and Immunology and the UNC-NC State Joint Department of Biomedical Engineering have developed a new strategy to improve drug-delivery into chronic wounds infections.
NTU Singapore
Why wavy wounds heal faster than straight wounds
19.05.2023
Wavy wounds heal faster than straight wounds because shapes influence cell movements, a team of researchers at Nanyang Technological University, Singapore (NTU Singapore) has found.
WFIRM
Bioprinting research makes history when it soars to the ISS
17.05.2023
The Wake Forest Institute for Regenerative Medicine (WFIRM) will make history this month when the first bioprinted solid tissue constructs soar to the International Space Station (ISS) on board the next all private astronaut mission by commercial space leader Axiom Space.
Max Planck Institute for Molecular Biomedicine
Microelectrode array: hammock for brain organoids
20.04.2023
Novel microelectrode array system enables long-term cultivation and electrophysiological analyses of brain organoids.
Cyborg and Bionic Systems
Bioprinting technology and AI enable high quality in vitro models
19.04.2023
In the process of organoid manufacturing, bioprinting technology not only facilitates the creation and maintenance of complex biological 3D shapes and structures, but also allows for standardization and quality control during production.
Fraunhofer-Translationszentrum/Fraunhofer ISC
SAPs4Tissue: human tissue models with customized biomaterials
12.04.2023
In a joint project of the Max Planck Institute for Polymer Research, Mainz, and the Translational Center for Regenerative Therapies at the Fraunhofer Institute for Silicate Research ISC, Würzburg, scientific principles and biomaterials for the standardized production of valid tissue models are to be developed.
Daniel Delang / TUM
Mini-heart in a Petri dish: organoid emulates development of the human heart
11.04.2023
The team working with Alessandra Moretti, Professor of Regenerative Medicine in Cardiovascular Disease, has developed a method for making a sort of "mini-heart" using pluripotent stem cells.
Fraunhofer ISC
Innovative in vitro eye irritation test to replace standard animal testing
10.03.2023
Researchers at the Translational Center for Regenerative Therapies TLC-RT of the Fraunhofer Institute for Silicate Research ISC want to work with partners to replace animal testing.
Satoshi Tanikawa, et al. 2023
Healing the brain: hydrogels enable neuronal tissue growth
03.03.2023
Synthetic hydrogels were shown to provide an effective scaffold for neuronal tissue growth in areas of brain damage, providing a possible approach for brain tissue reconstruction.
imagesourcecurated
Electrodes grown in the brain – paving the way for future therapies for neurological disorders
02.03.2023
The boundaries between biology and technology are becoming blurred. Researchers at Linköping, Lund, and Gothenburg universities in Sweden have successfully grown electrodes in living tissue using the body’s molecules as triggers. The result, published in the journal Science, paves the way for the formation of fully integrated electronic circuits in living organisms.
Vaibhav Srivastava
Mucus-based gel improves bone graft results, promotes healing
14.02.2023
Molecules from mucus can be used to produce synthetic bone graft material and help with the healing of larger bone loss, a new study found.
Beachbumledford
Controlled manufacture, storage and freezing of artificial retinal cells
25.01.2023
Fraunhofer researchers have now developed a new method for the production and clinical application of stem-cell-based retinal implants, which could contribute towards the successful treatment of AMD.
DegrooteStock
Wound care: healing with technology
01.12.2022
Wound care by nurses is directly about cleaning, sterile covering, and documentation. Medical and surgical interventions may also be necessary. In this context, wound care also offers potential for the use of technical aids that can help prevent complications.
ARTFULLY79
Technology in wound care: tools for better healing
01.12.2022
Wounds – both acute and chronic ones – can have many different causes. They all have in common that they require meticulous care because complications in wound healing can severely reduce both the patients’ health and quality of life. But there is more to modern wound care than just cleaning and bandaging them. Nursing staff and physicians can also access technical aids for this work.
Lena Holm
Scientists develop gel made from spider silk proteins for biomedical applications
19.08.2022
Researchers at Karolinska Institutet in Sweden and the Swedish University of Agricultural Sciences have discovered that spider silk proteins can be fused to biologically active proteins and be converted into a gel at body temperature.
Berthold Steinhilber
Ex vivo obesity research thanks to the adipose-on-chip system
08.07.2022
Ex vivo studies of human obesity without animal testing? The Adipose-on-Chip system offers a solution that allows scientists to gain better insights into various obesity-linked secondary diseases and comorbidities in the future.
Fibers for fibers – Textile implants repair the body
08.06.2022
We are nowadays already able to weave implants out of artificial fibers that can replace tissue or heal injuries. Different materials like polymers or nitinol are used to create flexible shapes. But the materials and their uses can still be improved.
Gabriel Salg/Universitätsklinikum Heidelberg
Using 3D printing to create insulin-producing cells
22.02.2022
3D printing opens a world of endless possibilities – for both industrial and medical applications. A cross-national project recently created tissue that produces insulin, spelling hope for patients with diabetes.
Tissue Engineering and Bioprinting – From artificial heart valves and printed humans
27.01.2021
Drug research and artificial skin replacement - these are the areas in which tissue engineering and bioprinting are already used today. What else could be possible in the future? We asked Dr. Nadine Nottrodt from Fraunhofer ILT and Prof. Sabine Neuß-Stein from RWTH Aachen University Hospital!
Multi-photon lithography: printing cells with micrometer accuracy
01.12.2020
How do cells react to certain drugs? And how exactly is new tissue created? This can be analyzed by using bioprinting to embed cells in fine frameworks. However, current methods are often imprecise or too slow to process cells before they are damaged. At the TU Vienna, a high-resolution bioprinting process has now been developed using a new bio-ink.
"Cells are highly sensitive" – material development for bioprinting
01.12.2020
The big hope of bioprinting is to someday be able to print whole human organs. So far, the process has been limited to testing platforms such as organs-on-a-chip. That's because the actual printing process already poses challenges. Scientists need suitable printing materials that ensure the cell's survival as it undergoes the procedure. The Fraunhofer IGB is researching and analyzing this aspect.
Bioprinting: life from the printer
01.12.2020
It aims at the production of test systems for drug research and gives patients on the waiting lists for donor organs hope: bioprinting. Thereby biologically functional tissues are printed. But how does that actually work? What are the different bioprinting methods? And can entire organs be printed with it? These and other questions are examined in our Topic of the Month.
Medical products made of collagen - Biocompatible, elastic, stable
19.03.2020
Regenerative medicine often relies on implants and materials that support healing in our body. Collagen has a special significance here. It is compatible to the body and offers an excellent environment for the growing of new cells. In our video, we took a look on where collagen and collagen products for medicine come from.
panthermedia.net/kasto
Cardiac Tissue Engineering: a heart out of the Petri dish
23.09.2019
For patients waiting for donor organs, every day can mean the difference between life and death. Making things even more complicated is the fact that not every organ is a compatible match with the patient. It would mean enormous progress if we could grow organs from the patient's own cells in the lab. That's why patients with heart disease place big hope in tissue engineering.
Multi-organ chips: Drug research without animal testing at vasQlab
15.05.2019
New active substances that are suitable for drugs are initially tested in animal experiments. However, the results cannot always be transferred to the human organism. At the Karlsruhe Institute of Technology, Prof. Ute Schepers from vasQlab explains how active substances can be tested in human tissue without endangering human health.