Thomas Dennison/University of Cambridge
Lab-grown 'mini-guts' offer new insights for Crohn’s disease treatments
06.09.2024
Researchers at the University of Cambridge have developed lab-grown "mini-guts" to better understand and treat Crohn’s disease, a chronic inflammatory bowel disease affecting millions worldwide. These mini-guts, or organoids, mimic the gut lining's key functions and could pave the way for more personalized and effective treatments.
S. Rieck/University Hospital Bonn (UKB)
Cardiovascular research: Generation of endothelial cells from stem cells
23.08.2024
Researchers at the University of Bonn and the University Hospital Bonn have developed a cost-effective and efficient method to generate functional endothelial cells from human induced pluripotent stem cells (hiPSCs).
VisioPrinTech: 3D-printed Cornea to restore eyesight
21.06.2024
The Karlsruhe Institute of Technology (KIT), in collaboration with Carl Zeiss Meditec AG and Evonik Healthcare, developed a method to restore eyesight by printing a new cornea during surgery using a laser-based process with personalized bioink. The "VisioPrinTech" process addresses corneal disorders, common among the aging population.
Barth van Rossum, FMP
Microscopy and fluorescence show how synapses are formed
23.10.2023
How are synapses formed, those points of contact that allow the transmission of information from one neuron to the other? Working with an international team, researchers from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) have now uncovered a crucial mechanism and elucidated the identity of the axonal transport vesicles that generates synapses.
Messe Düsseldorf
With stem cell model on the trail of congenital diaphragmatic hernia
09.05.2023
Researchers have designed a new stem cell model to study congenital diaphragmatic hernia in newborns with underdeveloped lungs. They were able to isolate stem cells from the fluid that is suctioned from the baby’s lungs and normally gets discarded and use them as a foundation for the model.
Giuseppe Intini
New approach helps skull bones mend themselves
24.04.2023
In a new study published in Proceedings of the National Academy of Sciences, University of Pittsburgh researchers developed a novel approach that promoted bone regeneration in mice without implantation of bone tissue or biomaterials.
Max Planck Institute for Molecular Biomedicine
Microelectrode array: hammock for brain organoids
20.04.2023
Novel microelectrode array system enables long-term cultivation and electrophysiological analyses of brain organoids.
Fraunhofer-Translationszentrum/Fraunhofer ISC
SAPs4Tissue: human tissue models with customized biomaterials
12.04.2023
In a joint project of the Max Planck Institute for Polymer Research, Mainz, and the Translational Center for Regenerative Therapies at the Fraunhofer Institute for Silicate Research ISC, Würzburg, scientific principles and biomaterials for the standardized production of valid tissue models are to be developed.
Daniel Delang / TUM
Mini-heart in a Petri dish: organoid emulates development of the human heart
11.04.2023
The team working with Alessandra Moretti, Professor of Regenerative Medicine in Cardiovascular Disease, has developed a method for making a sort of "mini-heart" using pluripotent stem cells.
JoPanwatD
AI finds targets for CAR-T cell therapy against acute myeloid leukemia
20.03.2023
Unlike other forms of blood cancer, acute myeloid leukemia (AML) cannot currently be treated with CAR-T cell immunotherapy. The reason is that specific molecular targets with which certain immune cells could specifically target AML cells are lacking, which would permit the immune system to attack cancer.
Colourbox
Stem cell model: research into malformation of the newborn lung
15.03.2023
Congenital diaphragmatic hernia is one of the deadliest birth defects. To better understand and treat this condition in the future, an international team of researchers involving Leipzig University Hospital designed a new cell model in the laboratory and tested a drug therapy on it.
Fraunhofer ISC
Innovative in vitro eye irritation test to replace standard animal testing
10.03.2023
Researchers at the Translational Center for Regenerative Therapies TLC-RT of the Fraunhofer Institute for Silicate Research ISC want to work with partners to replace animal testing.
Satoshi Tanikawa, et al. 2023
Healing the brain: hydrogels enable neuronal tissue growth
03.03.2023
Synthetic hydrogels were shown to provide an effective scaffold for neuronal tissue growth in areas of brain damage, providing a possible approach for brain tissue reconstruction.
DC_Studio
New artificial model validates antibodies ability to reach the brain
03.03.2023
A research group at Uppsala University has developed a simple and effective artificial blood-brain barrier model that can be used to determine how well antibody-based therapies can enter the brain.
Beachbumledford
Controlled manufacture, storage and freezing of artificial retinal cells
25.01.2023
Fraunhofer researchers have now developed a new method for the production and clinical application of stem-cell-based retinal implants, which could contribute towards the successful treatment of AMD.
Tissue Engineering and Bioprinting – From artificial heart valves and printed humans
27.01.2021
Drug research and artificial skin replacement - these are the areas in which tissue engineering and bioprinting are already used today. What else could be possible in the future? We asked Dr. Nadine Nottrodt from Fraunhofer ILT and Prof. Sabine Neuß-Stein from RWTH Aachen University Hospital!
Smartlab – Robotics and automation in the laboratory
15.09.2020
Some tasks in the laboratory are repetitive, need to be done extremely precise and require a lot of time. Such tasks are very tedious for humans, but they are tailor-made for robots. Such is the case with the "AutoCRAT" project at the Fraunhofer Institute for Production Technology IPT in Aachen. Here, a robotic platform is developed to produce stem cells for the treatment of osteoarthritis.
Regenerative medicine: helps the body healing
03.02.2020
Severe wounds heal slowly and leave scars. This is why we have been using regenerative therapies for some time now to accelerate and improve healing. They also help to avoid permanent damage. Still, complex applications like replacing organs or limbs will rather remain vision than become reality for a long time.
Regenerative medicine: creating a new body?
03.02.2020
Regenerative medicine aims to repair the human body after injuries, accidents or major cancer surgery. Unfortunately, we are still not at a stage where this process can achieve optimal results for every conceivable situation. Having said that, various new methods are on the cusp of breakthrough.
Organ-on-a-chip systems: limited validity?
01.02.2019
Organ-on-a-chip systems are technically a great enhancement of medical research because they facilitate testing of active ingredients on cell cultures in the chambers of a plastic chip. This replaces animal testing and improves patient safety. That being said, they are not a true-to-life replication of the human body and can only simulate a few functions and activities.