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Dementia: Blood levels could point to early loss of neuronal connections
01/07/2022
Researchers from DZNE and Ulm University Hospital have identified a protein in the blood that may indicate the degradation of neural connections years before the onset of dementia symptoms.
gpointstudio
New blood biomarker identified for status of fatty liver disease
29/06/2022
A MedUni Vienna study team has identified the role of a specific subtype of macrophages (white blood cells) in progressive non-alcoholic fatty liver disease.
twenty20photos
New hope for a therapy against retinitis pigmentosa
27/06/2022
Retinitis pigmentosa, a degenerative genetic disease of the eye, is characterized by progressive vision loss, usually leading to blindness.
bialasiewicz
Prospect of blood test for Parkinson’s disease for the first time
24/06/2022
A research team at the Faculty of Medicine at Kiel University has developed a method that reliably detects protein changes in blood that are typical of Parkinson's disease.
twenty20photos
New material paves the way for remote-controlled medication and electronic pills
23/06/2022
Biomedicines are produced by living cells and are used to treat cancer and autoimmune diseases among other things. One challenge is that the medicines are very expensive to produce, something that limits global access. Now researchers from Chalmers have invented a material that uses electrical signals to capture and release biomolecules.
engagestock
Protein changes in the liquor indicate inflammatory processes in the brain
23/06/2022
Alzheimer's, Parkinson's and other neurodegenerative diseases are associated with inflammatory processes in the brain. German researchers have succeeded in identifying a group of proteins in the cerebrospinal fluid that could provide information about such inflammatory processes.
Image-Source
Rapid whole genome sequencing improves diagnosis in critically ill infants
21/06/2022
Children who are born severely ill or who develop serious illness in the first few weeks of life are often difficult to diagnose, with considerable implications for their short and longer-term care.
New Oncohematology products
20/06/2022
Clonit, Innovation and Passion to serve Acute myeloid leukemia (AML) diagnosis and monitoring. We are pleased to announce the recent introduction of the new Oncohematology line of...
rawf8
Rapid test to measure immunity to COVID-19
17/06/2022
New blood assay provides critical information for revaccination strategies in vulnerable individuals.
BIH/David Ausserhofer
Ludovic Vallier grows liver tissue from stem cells
16/06/2022
Effective July 1, 2022, Ludovic Vallier will take up the W3 Einstein Strategic Professorship for Stem Cells in Regenerative Therapies at the Berlin Institute of Health at Charité (BIH).
Universität Bielefeld/M.-D. Müller
Making drug interactions in the liver visible
15/06/2022
Bielefeld University is coordinating a new EU-research project that seeks to produce microscopic liver tissue cultures that can survive for 14 days, while also using imaging methods to investigate how liver cells react to combinations of different medications.
mstandret
Identifying viruses more quickly
14/06/2022
The research project NanoXCAN involving Leibniz Universität Hannover aims to revolutionize virus imaging technology. The European Commission is funding the project with around 4 million euros. Every hospital could benefit, as a rapid and reliable identification of viral subtypes can save lives.
Klaus Nagels
Precise blood diagnostics improve treatment outcome for lung cancer
10/06/2022
Non-small cell lung carcinoma is a particularly aggressive type of lung cancer. Tumor cells and tumor DNA (ctDNA) in the blood of patients with the disease can be analyzed by means of liquid biopsy throughout the course of the disease.
twenty20photos
Genetic testing for neonatal epilepsy allows babies to go home sooner
09/06/2022
Genetic testing results in lower length of stay in the neonatal intensive care unit (NICU) for infants with epilepsy, according to a study published in the journal Pediatric Neurology.
Paula Heinke
Your liver is just under three years old
07/06/2022
The liver has a unique ability to regenerate after damage. However, it was unknown whether this ability decreases as we age. International scientists led by Dr. Olaf Bergmann at the Center for Regenerative Therapies Dresden (CRTD) at TU Dresden used a technique known as retrospective radiocarbon birth dating to determine the age of the human liver.
Lili Niu © Novo Nordisk Foundation, Center for Protein Research
Early diagnosis of liver diseases by proteomics
06/06/2022
Two or three drinks every day could put your liver in danger. Using proteomics and machine learning, researchers now present a revolutionary tool to predict whether an individual has alcohol-related liver disease and if an individual patient is at risk of disease progression.
UCLA Health
Biomarker panel could help predict gestational diabetes
31/05/2022
UCLA researchers have taken the initial step in identifying what may be an effective way to detect gestational diabetes mellitus (GDM) earlier in pregnancy, potentially improving diagnosis and treatment for what is the most common disorder of pregnancy.
Prostock-studio
Magnetic device isolates rarest white blood cells
27/05/2022
Across the world, food allergies are on the rise. One of the most important cells in studying this ailment are basophils, which activate inflammation and other responses to allergens such as rashes, and sometimes, anaphylaxis.
Juliet Percival/MPI für Biochemie
New method revolutionizes cancer diagnosis
24/05/2022
A German-Danish team led by Prof. Matthias Mann has developed a ground-breaking technology called 'Deep Visual Proteomics'. This method provides researchers and clinicians with a protein read-out to understand cancer at single cell-type resolution. The technology was published in the journal Nature Biotechnology and demonstrates its potential in a first application to cancer cells.
University of Cambridge
Brain scanners: Hope for treating cognitive symptoms in Parkinson’s
23/05/2022
Ultra-powerful 7T MRI scanners could be used to help identify those patients with Parkinson’s disease and similar conditions most likely to benefit from new treatments for previously-untreatable symptoms, say scientists.
AG Chumduri
Cervix: Research progress thanks to mini organs
23/05/2022
Life-like organ replicas - so-called 3D organoids - are a good way to research disease processes. A team from the University of Würzburg has now presented a kind of blueprint for such a model of the cervix.
M. Schober/E. Fuchs, Rockefeller University
New method melds data to make a 3-D map of cells’ activities
20/05/2022
HZI researchers develop molecular probes to detect pathogens in clinical samples.
HZI/Manfred Rohde
A bright spot for microbiological diagnostics
19/05/2022
HZI researchers develop molecular probes to detect pathogens in clinical samples.
Fraunhofer ILT, Aachen
Process chains for isolation and analysis: from single cells to organoids
17/05/2022
Researchers at the Fraunhofer Institute for Laser Technology ILT are working on new tools for the preparation and analysis of single cells and cell assemblies. The team developed the "Liftoscope", a system for cell sorting for subsequent cultivation that can analyze and transfer biomaterials precisely and in a way that is gentle on cells.
engagestock
New computational tool to interpret clinical significance of cancer mutations
12/05/2022
The software, called CancerVar, standardizes procedures to help researchers assess the clinical impacts of over 13 million somatic cancer mutations.
HiperScan
Fagron acquires majority share of Fraunhofer IPMS' spin-off HiperScan
10/05/2022
Fagron, a leading global company active in pharmaceutical compounding, announced on April 14th the acquisition of HiperScan, the German market leader for reliable raw material identification in pharmacies. HiperScan is a spin-off of Fraunhofer IPMS and the German market leader for reliable and secure identification of starting materials in pharmacies.
The Biodesign Institute at Arizona State University
A sharper image for proteins
05/05/2022
To fully understand proteins and their myriad functions, researchers have developed sophisticated means to see and study them using advanced microscopy, enhanced light detection, imaging software and the integration of advanced hardware systems. A new study from Arizona State University describes a new technique that promises to revolutionize the imaging of proteins and other vital biomolecules.
Kacey Ronaldson-Bouchard/Columbia Engineering
Plug-and-play organ-on-a-chip can be customized to the patient
05/05/2022
Major advance from Columbia Engineering team demonstrates first multi-organ chip made of engineered human tissues linked by vascular flow for improved modeling of systemic diseases like cancer
Nikita_Karchevskyi
Subgroups of glioblastoma associated with disease prognosis
02/05/2022
Researchers have detected different subgroups of the brain tumour form glioblastoma, where the cancer cells’ properties depend on which cell type they originate from. The used analysis method could also separate glioblastoma patients with significant differences in survival. The findings open up for identifying specific therapeutic targets for the new subgroups of glioblastoma.
Freya Lücke, UKSH
Leukaemia: Previously unknown risk factors in adulthood
29/04/2022
New research from the Clinical Research Unit "CATCH ALL" at Kiel University and UKSH identifies genetic causes for treatment resistance in BCP-ALL.
Carolin Schrandt
Lipidomics provides new biomarkers for cardiovascular disease and Type 2 Diabetes
27/04/2022
Using lipidomics, a modern analytical method, the team led by Dr. Fabian Eichelmann from DIfE and DZD identified those lipids that are statistically associated with cardiovascular disease and type 2 diabetes.
Karin Kaiser/MHH
Rare diseases: rapid diagnosis instead of a long odyssey
26/04/2022
Can the treatment of seriously ill children with rare diseases be improved by rapid genetic diagnosis? This question is being investigated by a team from Pediatrics and Human Genetics at Hannover Medical School (MHH) in the "Baby Lion" study. The focus is on decoding the genome, i.e. the entire genetic information of a human being, in just a few days.
Sandra Todaro/WFEG Rheinbach
Diagnostics: successful spin-off from the University of Bonn and LSI
26/04/2022
The British company APIS Assay Technologies Ltd has acquired the University of Bonn's spin-off project Clickmer Systems, which was further developed at the Life Science Inkubator (LSI), for a single-digit million euro sum. The startup is developing clickmers as a synthetic alternative to antibodies that can be utilized in research and medical diagnostics.
felipecaparros
Technology transfer award for PCR rapid test device for infection diagnostics
25/04/2022
Spindiag GmbH, together with the University of Freiburg and the Hahn-Schickard-Gesellschaft für angewandte Forschung e.V., was awarded the Technology Transfer Prize 2020 from the German Physical Society (DPG) on April 09, 2022 for the development of the PCR-based rapid test system Rhonda.
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World Laboratory Day 2022: Celebrate your lab!
22/04/2022
Drugs, vaccines, pathogen vulnerabilities, information about genetics and genetic material - the cornerstones of modern medicine are laid in research laboratories. And without efficient laboratory diagnostics, we would not be able to detect and treat a wide range of diseases. Two reasons to celebrate laboratories and the people who work there.
Zoltán Cseresnyés/Leibniz-HKI
How do fungal infections spread in the human lung?
22/04/2022
A chip model allows us to observe growth in the tissue.
microgen
Want to 3D print a kidney? Start by thinking small
21/04/2022
Stevens computational model aims to accelerate microfluidic bio-printing that opens up a pathway for 3D printing any kind of organ at any time.
Unimedizin Magdeburg
HFSP funding to study synaptic lipid signatures
19/04/2022
The astonishing capacity of the brain to process and store information crucially relies on properly functioning synapses. They provide the connecting entities within neural circuits and their properties define circuit function.
Andrew Davis Tucker/UGA
UGA team develops faster, cheaper COVID tests
18/04/2022
University of Georgia nanotechnology research group entered the race to develop a rapid test for COVID-19 in August 2020, running experiments on a new sensor for an American manufacturing company.
Photo courtesy of Houndstoothe Analytics
Highly accurate, 30-second coronavirus test
15/04/2022
Researchers at the University of Florida, however, have helped developed a COVID-19 testing device that can detect coronavirus infection in as little as 30 seconds as sensitively and accurately as a PCR, or polymerase chain reaction test, the gold standard of testing.
Sarah Needs, Cygnus smartphone testing technology
Dengue detection smartphone tech shows new hope for low-cost diagnostics
14/04/2022
Accurate home testing could be used for a wider range of illnesses, as new research shows the capability of smartphone-powered tests for Dengue Fever.
Nikos Hatzakis, University of Copenhagen
Revolutionary tool will meet future pandemics with accelerated response
07/04/2022
A new tool speeds up development of vaccines and other pharmaceutical products by more than one million times while minimizing costs.
Team Wolfgang Kastenmüller/Universität Würzburg
Immune system 'sentinel' cells key to immunotherapy
05/04/2022
The presence of dendritic cells, so-called 'sentinel' immune cells, is vital to maintain and regulate the balance of the body's immune response. Researchers have discovered an essential role of these cells in the treatment of cancer and severe viral infections.
Kripa Patel-Hillman Lab/Columbia Engineering
New technology could make biopsies a thing of the past
04/04/2022
MediSCAPE, a high-speed 3D microscope designed by Columbia Engineers, can see real-time cellular detail in living tissues to guide surgery, speed up tissue analyses, and improve treatments
beta web GmbH/Melanie Prüser
Single-use tests: sensitivity and easy use combined for diagnostics
12/12/2019
Diagnostic testing usually takes some time and a sterile environment to get the results. To cut down on the costs and effort spend on these tasks there are different diagnostic tests. One of them are single-use tests offered by SensDx S.A. The technology behind them not only makes the process faster and easier, but provides the opportunity to expand into home use in the future as well.
panthermedia.net/olanstock
Cardiac diagnostics – prompt and personalized
08/11/2019
If physicians suspect an acute myocardial infarction, they first order an ECG. This test is very established and allows cardiologists to quickly diagnose acute heart attacks – though the test does not detect less common heart attack symptoms. So far, those patients had to wait up to twelve hours before a heart attack could be accurately diagnosed or ruled out. But things are about the change.
Medicine at the pulse of time: Innovations and trends at MEDICA 2019
04/11/2019
Soon, the world's largest trade fair for medical technology will open its doors again: More than 5.000 exhibitors will present their newest products and ideas at MEDICA from 18 to 21 November. You will not only meet well-known companies here, but also lots of young start-ups. Or, you can visit the MEDICA forums and conferences to experience a rich program of lectures and discussions.
MEDICA LABMED FORUM: full speed ahead for careers in laboratory medicine
04/11/2019
Laboratories are medicine’s secret weapon because they handle the lion’s share of diagnostics often without patients even realizing it. That’s why the continuing workforce shortage in both laboratory medicine and companies is especially troubling. The MEDICA LABMED FORUM 2019 plans to address and counteract this development.
Fraunhofer ISS
AI software: "iSTIX opens your world to the possibilities of digital pathology"
08/10/2019
The healthcare market offers a multitude of microscopes that make cells visible to the human eye. The same applies to AI-based software for image analysis. After taking the microscopic images, scientist are faced with large volumes of scans with usually low resolution. Yet when all aspects merge together, they open up a the world of digital pathology.
panthermedia.net/kasto
Cardiac Tissue Engineering: a heart out of the Petri dish
23/09/2019
For patients waiting for donor organs, every day can mean the difference between life and death. Making things even more complicated is the fact that not every organ is a compatible match with the patient. It would mean enormous progress if we could grow organs from the patient's own cells in the lab. That's why patients with heart disease place big hope in tissue engineering.
Leibniz-IPHT/Sven Döring
Tumor excision: triple imaging for unique diagnostics
08/08/2019
After their tumor has been removed, some patients have to return to the hospital to undergo surgery again. That's because the tumor was not precisely identified and was subsequently not completely removed. That's both an ethical and financial dilemma. A new surgery-adjacent procedure is designed to rapidly and accurately detect tumors.
Last-resort antibiotics: "We can identify carbapenemases within half an hour"
01/08/2019
Antibiotic resistance is modern medicine's greatest challenge. Some bacteria only respond to a handful of antibiotics, prompting hospitals to spend a lot of time finding an effective drug. That’s why it is critical for physicians to rapidly identify antibiotic resistance to avoid ineffective treatments.
Combating antibiotic resistance: One step ahead through technology
01/08/2019
Antibiotic resistance is on the rise in all parts of the world, complicating medical treatment of serious bacterial infections in patients. The World Health Organization estimates that approximately 33,000 people die each year from antibiotic-resistant bacteria in Europe alone. Bacteria that are resistant to multiple or even all known antibiotics pose an ever-increasing threat.
Photonics: "We want a rapid and easy method to identify pathogens and antibiotic resistance"
01/08/2019
The medical devices value chain has gaps between academic research and industrial practice that slow down innovation processes. This also applies to time-sensitive and urgently needed products such as rapid diagnostic tests to identify resistant pathogens. At the InfectoGnostics Research Campus in Jena, partners from research and medicine team up to close these gaps.
Antibiotic resistance: technical tricks against pathogens
01/08/2019
An untreatable infection is a nightmare for physicians and potentially life-threatening to the patient. Unfortunately, more and more pathogens emerge that are resistant to drugs, especially antibiotics. We need to use our drugs smartly and come up with technical solutions as well to prevent our weapons from blunting in the future.
SilverSky LifeSciences GmbH
Striking new paths in medicine - Diagnostics Partnering Conference 2019
08/07/2019
On November 18th, 2019, parallel to the first day of MEDICA, the world forum for medicine, the Diagnostics Partnering Conference (DxPx Conference) will take place in Düsseldorf, bringing together stakeholders in the diagnostics and research tool industry. The DxPx Conference focuses on discovering technologies, finding financing and investment opportunities and forming collaborative partnerships.
Sven Delbeck/Fachhochschule Südwestfalen
Blood Sugar Monitoring: Using Infrared Instead of Invasive Techniques
22/03/2019
Over six million people in Germany have diabetes. It is estimated that almost 400 million people are affected by this disease worldwide. Diabetes sufferers must prick their fingers several times a day to monitor their blood sugar.
Comprehensive Treatment: It’s All About Breathing
01/03/2019
Coughing, airway obstruction, difficulty breathing: Chronic obstructive pulmonary disease (COPD) is an umbrella term used to describe progressive and currently incurable lung diseases. The innovative solutions of Philips Respironics help patients to manage each stage of the disease and their medication intake, train the respiratory system and provide respiratory support.
Multi-Organ Chips – The Patients of Tomorrow?
01/02/2019
The liver, nervous tissue or the intestines: all are important human organs that have in the past been tested for their function and compatibility using animal or in vitro test methods. In recent years, TissUse GmbH, a spin-off of the Technical University of Berlin (TU Berlin), has launched multi-organ chip platforms. But that’s not all.
Organ-on-a-chip systems: limited validity?
01/02/2019
Organ-on-a-chip systems are technically a great enhancement of medical research because they facilitate testing of active ingredients on cell cultures in the chambers of a plastic chip. This replaces animal testing and improves patient safety. That being said, they are not a true-to-life replication of the human body and can only simulate a few functions and activities.
Organ-on-a-chip - the mini organs of the future?
01/02/2019
So far in vitro methods and animal experiments have been used to determine the causes of diseases, research therapeutic approaches and predict the effect of drugs. Organ-on-a-chip models now offer a more accurate and ethically justifiable alternative. Find out more about the models, their advantages and future developments in our Topic of the Month.
Organ-on-a-chip – Organs in miniature format
01/02/2019
In vitro processes and animal tests are used to develop new medications and novel therapeutic approaches. However, animal testing raises important ethical concerns. Organ-on-a-chip models promise to be a feasible alternative. In a system the size of a smartphone, organs are connected using artificial circulation.
Diabetes digital – smart support for diabetics
02/01/2019
Monitoring blood sugar levels, counting carbohydrates, calculating insulin doses, and keeping accurate records - diabetes is a data-intensive disease that demands a lot of self-discipline and attention from the patients. Some concerns are patients neglecting to keep a food journal, "fudged" test results or calculation errors. Digital solutions help patients easily manage the large volumes of data.
A digital look inside the human eye – when algorithms diagnose Diabetes
02/01/2019
Diabetes mellitus or simply diabetes has become very common and is often described as a lifestyle disease. More and more people are suffering from this chronic metabolic disorder. Next to established diagnostic procedures, digital retinal screening has shown to be successful - a promising technique that will also play an important role in the diagnosis of other diseases in the future.
DiaDigital: making sense of diabetes apps
02/01/2019
While they are very useful, health apps have one major drawback: anyone can release and distribute them unchecked. Only some apps require medical device certification. So how can users spot a great, safe and useful app? When it comes to diabetes apps, the “DiaDigital” seal of distinction is the answer.
Blood glucose monitoring of tomorrow - modern diabetes therapies
02/01/2019
There are 425 million people with diabetes in the world. Heart problems, kidney failure or blindness - these can all be consequences of the metabolic disease. Diabetes patients now have the possibility of being treated digitally.
Astrid Eckert
Pathology 4.0 – inveox automates laboratory processes
22/08/2018
Mix-ups, contamination and sample loss – most errors in pathology happen when specimen are received. Countless samples arrive daily at the laboratory, while the sample entry process is very monotonous. As a result, the work is inefficient. The start-up company inveox has now developed a system that automates the processes in the pathology laboratory, thus making them more efficient.
panthermedia.net/Mario Hahn
Early detection: Tattoo signals cancer – and more
09/07/2018
People who are not ill and do not show any symptoms typically do not visit the doctor. And while most people know that preventive medical checkups for cancer, for example, are important, they still avoid them. They tend to be very hesitant because the doctor might detect a serious illness. In the future, a new type of implant could make it easier to go to a screening test.
Daniel Klaue, ZELLMECHANIK DRESDEN GmbH
Cells in the speed trap – diagnosis in a matter of seconds
22/06/2018
A drop of blood provides a lot of valuable information. However, it takes several hours to analyze the blood of a patient and make a diagnosis. This takes away a lot of time that's crucial for treatment. A new method intends to considerably speed up this process by testing the cells in the blood in terms of their deformability and immune response.
Leibniz University of Hanover/Institute of Technical Chemistry
Tissue engineering: how to grow a bypass
23/04/2018
A bypass is a complicated structure. It is either made of synthetic materials that can cause blood clots and infections or created by using the patient’s veins. However, the latter often does not yield adequate material. A newly developed bioreactor could solve this problem in the future. It is designed to tissue engineer vascular grafts by using the body’s own material.
Dr. Markus Wehland
Cells in space – extraterrestrial approaches in cancer research
22/02/2018
Here on Earth, all experiments are bound by gravitation. Yet, freed from gravity's grip, tumor cells, for example, behave in an entirely different way. As part of the "Thyroid Cancer Cells in Space" project by the University of Magdeburg, smartphone-sized containers carrying poorly differentiated thyroid cancer cells are sent into space.
Empa
"Spray-On" muscle fibers for biomimetic surfaces
08/01/2018
Few patients with heart failure are fortunate enough to receive a donor's heart. Ventricular assist devices (or heart pumps) have been around for several years and are designed to buy time as patients wait for a transplant. Unfortunately, the body doesn't always tolerate these devices.