Organ-on-a-chip - the mini organs of the future? -- MEDICA - World Forum for Medicine

Bild: A research team of two works in the laboratory with a laptop. Analyzing the results; Copyright: Hoverstock

Hoverstock

Sequential antibiotic therapy in the laboratory and in patients

23/01/2023

Rapid switching between different antibiotics could prevent the evolution of resistance and lead to successful treatment of patients.
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Image: Researcher examines cell culture plates under the microscope; Copyright: manjurulhaque

manjurulhaque

Analyzing disease progression and cell processes with TIGER: in vivo and non-invasively

18/01/2023

Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) and the Julius-Maximilians-Universität (JMU) in Würzburg have developed a technology they call TIGER. It allows complex processes in individual cells to be deciphered in vivo by recording past RNA transcripts.
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kwanruanp

DZHK establishes two central biobanks - cooperation partners welcome

16/01/2023

The German Center for Cardiovascular Research is centralizing its biospecimens collections, which are currently stored at 60 sites. Therefore, it is looking for two biobanks as scientific cooperation partners. Applications are now open to all German biobanks.
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Image: Close-up Of A Man Checking Blood Sugar Level At Home With Glucometer And Test Strips; Copyright: dolgachov

dolgachov

Type 2 diabetes: Machine learning can predict poor glycemic control from patient information systems

13/01/2023

The risk for poor glycemic control in patients with type 2 diabetes can be predicted with confidence by using machine learning methods, a new study from Finland finds.
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Image: Two men and two women are standing in a laboratory and examining a small apparatus (microphysiological system); Copyright: Amac Garbe/Fraunhofer IWS

Amac Garbe/Fraunhofer IWS

Radioactive substances fight cancer in the mini-lab

13/01/2023

Two Dresden research institutes want to reduce the number of animal experiments in radiopharmaceutical research with a new idea.
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Image: Two doctors in scrubs look at a screen during an AI-assisted colonoscopy; Copyright: Universitätsklinikum Bonn (UKB)

Universitätsklinikum Bonn (UKB)

AI improves colorectal cancer screening in Lynch syndrome

10/01/2023

Researchers at the National Center for Hereditary Tumor Diseases (NZET) at Bonn University Hospital (UKB) have now found that artificial intelligence (AI) can improve the effectiveness of colonoscopy in the presence of Lynch syndrome.
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Aalto University

Gaining unprecedented view of small molecules by machine learning

06/01/2023

A new tool to identify small molecules offers benefits for diagnostics, drug discovery and fundamental research. A new machine learning model will help scientists identify small molecules, with applications in medicine, drug discovery and environmental chemistry.
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Image: Position of molecules on nanoparticle surfaces as a 3D illustration; Copyright: Max-Planck-Institut für Polymerforschung

Max-Planck-Institut für Polymerforschung

How optical microscopes allow detailed investigations of nanoparticles

06/01/2023

In their project "Supercol"- funded by the European Union - scientists want to achieve the investigation of nanoparticles with light.
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Image: A woman in a white coat with blue gloves sits at a large microscope; Copyright: LZH

LZH

Detecting bacterial infestation fast, contactless, and free of markers

05/01/2023

With a multimodal microscope, the Laser Zentrum Hannover e.V. (LZH) and three partners in the joint project PriMe want to make it possible to detect bacterial infestation using fast, marker-free, and contactless imaging.
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Image: A woman with brown hair in a black top, Prof.'in Dr. Charlotte Uetrecht looking into the camera; Copyright: Sascha Hüttenhain

Sascha Hüttenhain

Shedding new light on viruses

22/12/2022

Professor Dr. Charlotte Uetrecht from the University of Siegen is studying the structures of proteins and protein complexes in coronaviruses and noroviruses, and how they change over the viral lifecycle.
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Image: A doctor examines a brain scan in the laboratory; Copyright: XiXinXing

XiXinXing

Map of the brain's- and cerebrospinal fluid's immune cells

21/12/2022

Neuroscientists from the University of Münster have now generated an atlas that could change this: using it will allow to better understand disease mechanisms and to study the effects of therapies in a new way. This invaluable resource is provided as a freely available software for researchers all around the world.
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University of the Basque Country

Micrometric blood plasma separator using high-resolution 3D fabrication

16/12/2022

Researchers at the UPV/EHU-University of the Basque Country have developed a microfluidic plasma separator to optically detect blood biomarkers.
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Image: Scientists pipette a DNA sample into a multi-well plate ready for genetic testing in a laboratory; Copyright: westend61

westend61

Ground-breaking new method for multi-cancer early detection

16/12/2022

An international study led by researchers from Chalmers University of Technology, Sweden, shows that a new, previously untested method can easily find multiple types of newly formed cancers at the same time – including cancer types that are difficult to detect with comparable methods.
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Image: Prof. Lachmann uses different scalable systems to continuously produce specific mature human immune cells from induced pluripotent stem cells.; Copyright: Fraunhofer ITEM

Fraunhofer ITEM

Designer immune cells for drug discovery, potency and safety testing

14/12/2022

Fraunhofer researchers have succeeded in scaling the production of customized immune cells from laboratory up to industrial level.
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Image: Microscopic images of lab-grown mini-retinas; Copyright: Völkner et al., Nat. Comm., 2022

Völkner et al., Nat. Comm., 2022

Macular degeneration: new potential mechanism for vision loss discovered

09/12/2022

Thanks to laboratory produced human mini-retinas, researchers were able to observe complex changes in the retina as they occur in macular degeneration. This enabled them to discover the so-called cell extrusion as a potential mechanism for neurodegenerative diseases.
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mstandret

Why are overweight people more susceptible to illness?

07/12/2022

If you gain weight, the fat cells in the body get bigger. So in the extremely obese, those fat cells are greatly enlarged. Now, researchers from the Technical University of Munich (TUM) were able to show how enlarged fat cells can cause metabolic diseases. They also developed non-invasive examination methods to determine the size of human fat cells.
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Image: Close-up: The complex architecture of the neuroepithelial organoids with cell membranes; Copyright: Keisuke Ishihara

Keisuke Ishihara

Measuring organ development

28/11/2022

Researchers from Dresden and Vienna reveal link between connectivity of three-dimensional structures in tissues and the emergence of their architecture to help scientists engineer self-organising tissues that mimic human organs.
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Image: Close-up of a male chest-shoulder area with a tattoo-like drawing on the skin that is supposed to represent a gene cluster; Copyright: Polygraph Design

Polygraph Design

How genes and small molecules influence personal disease risk

25/11/2022

In an international collaboration with partners from Cambridge (UK), scientists from the Berlin Institute of Health at the Charité (BIH) have now discovered more than 300 regions in the genome that contribute to this individual chemical fingerprint. They have now published their results in Nature Medicine.
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Image: A man in a blue shirt sits at a desk and smiles at the camera; Copyright: University of Oslo

University of Oslo

Resistances: these bacteria hide and then take charge

23/11/2022

A doctor discovers bacteria in a sample that is causing a case of pneumonia and prescribes antibiotics. But at the same time, there is another, nastier variant of bacteria lurking in the patient’s body that is very glad to have got rid of its competitor.
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Image: A square large gray box in the lab. Microfluidic readout unit for subsequent clinical multiplex analysis; Copyright: Fraunhofer ILT, Aachen

Fraunhofer ILT, Aachen

Multiplex analysis with para-magnetic microparticles

18/11/2022

A team from the Fraunhofer Institute for Laser Technology ILT in Aachen has developed a new readout unit for para-magnetic particles in a microfluidic system.
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Image: A small square apparatus, an electrochemical sensing platform for studying in vitro vascular systems. The channels and reservoirs were visualized using blue ink.; Copyright: Tohoku University

Tohoku University

Sensing platform for studying in vitro vascular systems

11/11/2022

The costliness of drug development and the limitations of studying physiological processes in the lab are two separate scientific issues that may share the same solution.
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Image: Mobile laboratory unit with integrated lifting device for a standard truck chassis; Copyright: Fraunhofer IBMT/Markus Michel

Fraunhofer IBMT/Markus Michel

MEDICA 2022: Biological laboratory to go

10/11/2022

Researchers from the Fraunhofer Institute for Biomedical Engineering IBMT have developed the “BioSensoLab“, a mobile biological laboratory with which they can demonstrate new developments to customers and test them together – on site at their companies.
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Image: Close-up of a hand in a blue laboratory glove putting a sample of blood under a microscope; Copyright: prostooleh

prostooleh

New initiative to INDICATE cancer risks

28/10/2022

INDICATE, an international collaborative initiative to unravel the role of the Human Leukocyte Antigen type as risk modifier in individuals with a genetic cancer predisposition.
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Image: Close-up of a hand in a blue laboratory glove using a pipette to fill samples into a row of micro test tubes; Copyright: sommthink/Shutterstock

sommthink/Shutterstock

Head and neck cancer: Markers to facilitate better treatment in the future

27/10/2022

Malignant tumours in the head and neck region are very heterogeneous and therefore difficult to treat. A joint study by MedUni Vienna and the Christian Doppler Laboratory for Applied Metabolomics focused on the development and identification of specific markers to improve risk assessment for patients.
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Image: diagnostic test on a table; Copyright: beta web GmbH/Melanie Prüser

beta web GmbH/Melanie Prüser

Single-use tests: sensitivity and easy use combined for diagnostics

12/12/2019

Diagnostic testing usually takes some time and a sterile environment to get the results. To cut down on the costs and effort spend on these tasks there are different diagnostic tests. One of them are single-use tests offered by SensDx S.A. The technology behind them not only makes the process faster and easier, but provides the opportunity to expand into home use in the future as well.
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Image: Blood sample labelled

panthermedia.net/olanstock

Cardiac diagnostics – prompt and personalized

08/11/2019

If physicians suspect an acute myocardial infarction, they first order an ECG. This test is very established and allows cardiologists to quickly diagnose acute heart attacks – though the test does not detect less common heart attack symptoms. So far, those patients had to wait up to twelve hours before a heart attack could be accurately diagnosed or ruled out. But things are about the change.
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Medicine at the pulse of time: Innovations and trends at MEDICA 2019

04/11/2019

Soon, the world's largest trade fair for medical technology will open its doors again: More than 5.000 exhibitors will present their newest products and ideas at MEDICA from 18 to 21 November. You will not only meet well-known companies here, but also lots of young start-ups. Or, you can visit the MEDICA forums and conferences to experience a rich program of lectures and discussions.
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Image: A little toy figure of a man in a suit is standing on a print-out of DNA sequencing; Copyright: panthermedia.net/filmfoto

MEDICA LABMED FORUM: full speed ahead for careers in laboratory medicine

04/11/2019

Laboratories are medicine’s secret weapon because they handle the lion’s share of diagnostics often without patients even realizing it. That’s why the continuing workforce shortage in both laboratory medicine and companies is especially troubling. The MEDICA LABMED FORUM 2019 plans to address and counteract this development.
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Image: Volker Bruns; Copyright: Fraunhofer ISS

Fraunhofer ISS

AI software: "iSTIX opens your world to the possibilities of digital pathology"

08/10/2019

The healthcare market offers a multitude of microscopes that make cells visible to the human eye. The same applies to AI-based software for image analysis. After taking the microscopic images, scientist are faced with large volumes of scans with usually low resolution. Yet when all aspects merge together, they open up a the world of digital pathology.
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Image: MEDICA START-UP PARK; Copyright: Messe Düsseldorf/ctillmann

MEDICA START-UP PARK: "For those, who want to experience the startup-spirit"

01/10/2019

When the halls of MEDICA are open to the world to showcase medical innovations, one joint exhibition booth is guaranteed to attract special attention - the MEDICA START-UP PARK. The startups that present their advances in this setting are interesting to visitors and investors, yet long-time exhibitors and big businesses can also benefit from building relationships with these young companies.
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Image: Man with mouthguard and laboratory glasses holding Petri dish up; Copyright: panthermedia.net/kasto

panthermedia.net/kasto

Cardiac Tissue Engineering: a heart out of the Petri dish

23/09/2019

For patients waiting for donor organs, every day can mean the difference between life and death. Making things even more complicated is the fact that not every organ is a compatible match with the patient. It would mean enormous progress if we could grow organs from the patient's own cells in the lab. That's why patients with heart disease place big hope in tissue engineering.
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Image: Participants of the German Medical Award 2018; Copyright: German Medical Award

German Medical Award

German Medical Award 2019 celebrates the future of (patient) care

22/08/2019

The German Medical Award will take place on November 18, 2019, as part of the MEDICA trade fair in Düsseldorf. The ceremony emphasizes the commitment to excellence in cutting-edge care for patients. Doctors, clinical centers and companies in the medical and healthcare industry can demonstrate their achievements in medicine and management in hopes of receiving the coveted award.
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Image: Laboratory situation - Prof. Popp shows a young man a small object in his hand; Copyright: Leibniz-IPHT/Sven Döring

Leibniz-IPHT/Sven Döring

Tumor excision: triple imaging for unique diagnostics

08/08/2019

After their tumor has been removed, some patients have to return to the hospital to undergo surgery again. That's because the tumor was not precisely identified and was subsequently not completely removed. That's both an ethical and financial dilemma. A new surgery-adjacent procedure is designed to rapidly and accurately detect tumors.
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Image: Two petri dishes with different kinds of agar plates on which bacterial cultures are growing; Copyright: panthermedia.net/photographee.eu

Antibiotic resistance: technical tricks against pathogens

01/08/2019

An untreatable infection is a nightmare for physicians and potentially life-threatening to the patient. Unfortunately, more and more pathogens emerge that are resistant to drugs, especially antibiotics. We need to use our drugs smartly and come up with technical solutions as well to prevent our weapons from blunting in the future.
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Image: A lab technician is using a pipette to fill a solution into a petri dish; Copyright: panthermedia.net/Arne Trautmann

Last-resort antibiotics: "We can identify carbapenemases within half an hour"

01/08/2019

Antibiotic resistance is modern medicine's greatest challenge. Some bacteria only respond to a handful of antibiotics, prompting hospitals to spend a lot of time finding an effective drug. That’s why it is critical for physicians to rapidly identify antibiotic resistance to avoid ineffective treatments.
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SilverSky LifeSciences GmbH

Striking new paths in medicine - Diagnostics Partnering Conference 2019

08/07/2019

On November 18th, 2019, parallel to the first day of MEDICA, the world forum for medicine, the Diagnostics Partnering Conference (DxPx Conference) will take place in Düsseldorf, bringing together stakeholders in the diagnostics and research tool industry. The DxPx Conference focuses on discovering technologies, finding financing and investment opportunities and forming collaborative partnerships.
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Image: Man and woman in a laboratory presenting a multi-organ chip; Copyright: TissUse GmbH

Multi-Organ Chips – The Patients of Tomorrow?

01/02/2019

The liver, nervous tissue or the intestines: all are important human organs that have in the past been tested for their function and compatibility using animal or in vitro test methods. In recent years, TissUse GmbH, a spin-off of the Technical University of Berlin (TU Berlin), has launched multi-organ chip platforms. But that’s not all.
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Image: Graphic rendering of several cells in a petri dish; Copyright: panthermedia.net/dani3315

Organ-on-a-chip systems: limited validity?

01/02/2019

Organ-on-a-chip systems are technically a great enhancement of medical research because they facilitate testing of active ingredients on cell cultures in the chambers of a plastic chip. This replaces animal testing and improves patient safety. That being said, they are not a true-to-life replication of the human body and can only simulate a few functions and activities.
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Image: Cell cultivation in a Petri dish; Copyright: panthermedia.net / matej kastelic

Organ-on-a-chip – Organs in miniature format

01/02/2019

In vitro processes and animal tests are used to develop new medications and novel therapeutic approaches. However, animal testing raises important ethical concerns. Organ-on-a-chip models promise to be a feasible alternative. In a system the size of a smartphone, organs are connected using artificial circulation.
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