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Image: high-resolution fluorescence imaging of activated fibroblasts; Copyright: Wang Mao, Duke-NUS Medical School

Genetics: cardiac fibrosis study identifies key proteins

13.09.2019

Using cutting-edge technologies, researchers at Duke-NUS Medical School, Singapore, have developed the first genome-wide dataset on protein translation during fibroblast activation, revealing a network of RNA-binding proteins (RBPs) that play a key role in the formation of disease-causing fibrous tissue in the heart.
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Image: tissue grown on a capillary bridge; Copyright: MPI of Colloids and Interfaces/ Sebastian Ehrig

Tissue engineering: Form is function

12.09.2019

Liquid-like tissue behavior is a key principle for the formation of structures in biological systems. Researchers at the Max Planck Institute of Colloids and Interfaces in Potsdam have shown that growing bone tissue behaves like a viscous liquid on long time scales, thereby accepting forms with minimal surface area.
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Image: fat cells; Copyright: panthermedia.net/sciencepics

Genetics: women's deep belly fat strongly linked to diabetes

12.09.2019

A comprehensive study from Uppsala University, with over 325,000 participants, shows that deep belly fat is a major contributing risk factor for developing diabetes and cardiovascular disease. Moreover, the scientists investigated how our genes affect the accumulation of fat and present a new, simpler method to estimate the amount of deep belly fat.
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Image: dna strings in yellow, blue and red; Copyright: panthermedia.net/khenghotoh

DNA: construction kit replaces expensive antibody medication

11.09.2019

Researchers at KU Leuven in Belgium have developed a technique to make sheep produce new antibodies simply by injecting the DNA building blocks. This approach is much cheaper and more efficient than producing antibodies industrially and administering them afterwards. The study in animals with a similar size as humans brings us a step closer to the clinical use of antibody gene therapy.
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Image: electronic platforms in different shapes; Copyright: Muhammad Hussain

Wearables: reconfigurable electronics promising innovations

11.09.2019

Medical implants of the future may feature reconfigurable electronic platforms that can morph in shape and size dynamically as bodies change or transform to relocate from one area to monitor another within our bodies.
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Image: scan of a lung; Copyright: panthermedia.net/Guzel

Imaging: reducing lung cancer mortality

10.09.2019

A combination of the EarlyCDT-Lung Test followed by CT imaging in Scottish patients at risk for lung cancer resulted in a significant decrease in late stage diagnosis of lung cancer and may decrease lung cancer specific mortality, according to research presented at IASLC 2019 World Conference on Lung Cancer hosted by the International Association for the Study of Lung Cancer (IASLC).
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Image: woman sitting down; Copyright: panthermedia.net/photographee

Stem cells: antihistamines can kill leukaemic stem cells

09.09.2019

The IJC Leukaemic Stem Cell research group, led by Ruth M. Risueño, has discovered in preclinical trials that a particular group of antihistamines can kill leukaemic stem cells. This group investigates Acute Myeloid Leukaemia (AML) and the cell population responsible for the disease spreading, persisting, and if it has been treated and overcome, reappear.
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 Image: reasearcher in laboratory; Copyright: panthermedia.net/kasto

Islet-on-a-chip: miniature device for diabetes research

30.08.2019

In a study led by Harvard University's Kevin Kit Parker, microfluidics and human, insulin-producing beta cells have been integrated in an "Islet-on-a-Chip". The new device makes it easier for scientists to screen insulin-producing cells before transplanting them into a patient, test insulin-stimulating compounds, and study the fundamental biology of diabetes.
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Image: DNA strand; Copyright: panthermedia.net/everythingposs

Analyzing systems: technique stores cellular 'memory' in DNA

29.08.2019

Engineers program human and bacterial cells to keep a record of complex molecular events. Using a technique that can precisely edit DNA bases, MIT researchers have created a way to store complex "memories" in the DNA of living cells, including human cells.
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Image: Tissue engeneering – mouse pulmonary artery model; Copyright: Alain Herzog / 2019 EPFL

Tissue Engeneering: bioprinting complex living tissue

26.08.2019

Tissue engineers create artificial organs and tissues that can be used to develop and test new drugs, repair damaged tissue and even replace entire organs in the human body. However, current fabrication methods limit their ability to produce free-form shapes and achieve high cell viability.
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Image: Rodins The Thinker with yellow-brownish structures around it; Copyright:

Laboratory medicine: biomaterials smarten up with CRISPR

23.08.2019

The CRISPR-Cas system has become the go-to tool for researchers who study genes in an ever-growing list of organisms, and is being used to develop new gene therapies that potentially can correct a defect at a single nucleotide position of the vast reaches of the genome.
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Image: Two ellbows affected by psoriasis; Copyright: panthermedia.net/Hriana

Shedding light on PUVA light therapy for skin diseases

22.08.2019

Together with their Munich-based colleagues, a team of physical chemists from Heinrich Heine University Düsseldorf (HHU) has clarified which chemical reactions take place during PUVA therapy. The therapy involves light-induced damage to the DNA of diseased cells. The team working under Prof. Peter Gilch has now published its findings in the Journal of the American Chemical Society.
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Image: blood samples; Copyright: Max Planck Institute for Biology of Ageing

Biomarker: health indication in old age

21.08.2019

Researchers on ageing from the Max Planck Institute for Biology of Ageing and the Leiden University Medical Center (LUMC) collaborate to link basic insights from model organisms to the causes of ageing in humans. They can determine the disease vulnerability of older people using a defined set of substances in the blood.
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Image: nanoparticles in a close-up; Copyright: panthermedia.net/raimund14

Precision medicine: graphene nanoflakes as a new tool

20.08.2019

Chemists funded by the SNSF have created a new compound for flexible drug delivery that specifically targets prostate cancer cells. Incorporating four different molecules, the compound prevents tumour cells from multiplying, can be detected by medical imaging and has staying power in the bloodstream.
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Image: Cells of the retinal pigment epithelium; Copyright: Julia Johansson and Teemu Ihalainen, Tampere University

Sensory cells: new insight on retinal diseases

19.08.2019

Finnish researchers have found cellular components in the epithelial tissue of the eye, which have previously been thought to only be present in electrically active tissues, such as those in nerves and the heart. A study at Tampere University found that these components, voltage-gated sodium (Nav) channels, are involved in the renewal of sensory cells in the adjacent neural tissue, the retina.
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Image: self-calibrating endoscope; Copyright: J. Czarske, TU Dresden, Germany

Imaging: 3D images of objects smaller than a cell

19.08.2019

Researchers have developed a new self-calibrating endoscope that produces 3D images of objects smaller than a single cell. Without a lens or any optical, electrical or mechanical components, the tip of the endoscope measures just 200 microns across, about the width of a few human hairs twisted together.
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Image: illustration of nanodestructive characterization of stem cell differentiation through exosomal miRNA detection; Copyright: Jin-Ho Lee/Rutgers University-New Brunswick

Nanotechnology: better stem cell transplantation research

15.08.2019

Nanotechnology developed at Rutgers University-New Brunswick could boost research on stem cell transplantation, which may help people with Alzheimer's disease, Parkinson's disease, other neurodegenerative diseases and central nervous system injuries.
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Image: man - Muhammed Murtaza - in the laboratory; Copyright: Courtesy of TGen

Blood test: liquid biopsy improves breast cancer diagnostics

14.08.2019

A new type of blood test for breast cancer could help avoid thousands of unnecessary surgeries and otherwise precisely monitor disease progression, according to a study led by the Translational Genomics Research Institute (TGen) and Mayo Clinic in Arizona.
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Image: two men in the laboratory; Copyright: DGIST

Diagnostics: mass spectrometric technique using laser and graphene

12.08.2019

A technology that can obtain high-resolution, micrometer-sized images for mass spectrometric analysis without sample preparation has been developed. DGIST Research Fellow Jae Young Kim and Chair-professor Dae Won Moon's team succeeded in developing the precise analysis and micrometer-sized imaging of bio samples using a small and inexpensive laser.
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Image:  bone tissue replicated with 3D technology; Copyright: panthermedia.net/eranicle

Regenerative medicine: 'Bone in a dish'

07.08.2019

Like real bone, the material developed at Oregon Health & Science University has a 3D mineral structure populated with living cells, providing a unique model to study bone function, diseases, regeneration.
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Image: Mouse cochlea with hair cells shown in green and auditory nerves shown in red.; Copyright: Doetzlhofer lab

Tissue engineering: restoring damaged cells in the ear

06.08.2019

Using genetic tools in mice, researchers at Johns Hopkins Medicine say they have identified a pair of proteins that precisely control when sound-detecting cells, known as hair cells, are born in the mammalian inner ear. The proteins, described in a report published June 12 in eLife, may hold a key to future therapies to restore hearing in people with irreversible deafness.
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Image: Multi-Electrode Layout for Parallel Analysis of Multiple Cell Samples in Microfluic-Chips.; Copyright: Fraunhofer EMFT, Bernd Müller

Cell observation: new approach in the fight against viruses

06.08.2019

In the ViroSens project, researchers from the Fraunhofer-Gesellschaft in Sulzbach and Regensburg are working together with industrial partners on a novel analytical method to make the potency testing of vaccines more efficient and cost-effective.
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Image: The signalling protein Fyn moving and forming clusters in living brain cells - viewed using super-resolution microscopy.; Copyright: Meunier Lab, University of Queensland

Dementia: Super-resolution microscopy sheds light

05.08.2019

University of Queensland researchers have used super-resolution microscopy to observe key molecules at work inside living brain cells, further unravelling the puzzle of memory formation and the elusive causes of dementia.
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Image: A researcher displays the pliability of a trileaf heart valve bioprinted in collagen.; Copyright: Carnegie Mellon University College of Engineering

Tissue engineering: 3D printing the human heart

05.08.2019

A team of researchers from Carnegie Mellon University has published a paper in Science that details a new technique allowing anyone to 3D bioprint tissue scaffolds out of collagen, the major structural protein in the human body. This first-of-its-kind method brings the field of tissue engineering one step closer to being able to 3D print a full-sized, adult human heart.
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Image: Man who had a stroke might be treated with thrombectomy; Copyright: panthermedia.net/olegdudko

Thrombectomy: potential treatment for larger strokes

31.07.2019

Building on research results published today in JAMA Neurology showing patients with larger ischemic strokes could benefit from endovascular thrombectomy, an international, multicenter Phase III clinical trial will be starting at The University of Texas Health Science Center at Houston (UTHealth).
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Image: sterile titanium blanks; Copyright: Sergey Gnuskov/NUST MISIS

Implants: hybrid implant imitates bone structure

25.07.2019

The National University of Science and Technology MISIS together with their colleagues from the N.N. Blokhin National Medical Research Centre of oncology developed a unique implant to replace the damaged bone fragment. The implant, which imitates real bone structure, was installed to a domestic cat with osteosarcoma by surgeons of the veterinary clinic "Biocontrol".
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Image: blood test; Copyright: panthermedia.net/belchonock

Blood test: may also identify people at most TB risk

23.07.2019

A new study conducted by researchers in Leicester and Nottingham has shown the potential for a new blood test to not only diagnose human tuberculosis (TB) but also identify those at most risk of developing the disease.
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Image: Two men in the zoo holding turtles in their hands; Copyright: Oliver Dietze

Diagnostics: Animal blood samples help predict human diseases

17.07.2019

Penguins, Asian elephants and many other animal species live in the zoos of Saarbrücken and Neunkirchen. As they come from different continents, blood is regularly taken from the animals to check their health.
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Image: A drawn image of the human spine with a hole in it; Copyright: panthermedia.net/lightsource

Nanotechnology: an 'EpiPen' for spinal cord injuries

15.07.2019

An injection of nanoparticles can prevent the body's immune system from overreacting to trauma, potentially preventing some spinal cord injuries from resulting in paralysis. The approach was demonstrated in mice at the University of Michigan, with the nanoparticles enhancing healing by reprogramming the aggressive immune cells.
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Image: sensor; Copyright: Purdue University

Diagnostics: 3D mapping technology to monitor and track cells and tissues

11.07.2019

Medical advancements can come at a physical cost. Often following diagnosis and treatment for cancer and other diseases, patients' organs and cells can remain healed but damaged from the medical condition. In fact, one of the fastest growing medical markets is healing and/or replacing organs and cells already treated, yet remain damaged by cancer, cardiovascular disease and other medical issues.
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Image: imCMS model; Copyright: University of Zurich

AI: molecular tumor classification and prognosis in patients with colorectal cancer

09.07.2019

Treating physicians need information about the molecular subtype of the tumor if they are to provide targeted therapy for colorectal carcinoma. A research team from University Hospital Zurich and the University of Oxford have now developed a method to predict the molecular classification of colorectal cancer from digital pathology slides.
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Image: elderly man in the lab injecting a liquid into a chip; Copyright: panthermedia.net/matej kastelic

Human-on-a-chip: prediction of in vivo results based on in vitro model

08.07.2019

Hesperos Inc., pioneers of the human-on-a-chip in vitro system has announced the use of its innovative multi-organ model to successfully measure the concentration and metabolism of two known cardiotoxic small molecules over time, to accurately describe the drug behavior and toxic effects in vivo. The findings support the potential of body-on-a-chip systems to transform the drug discovery process.
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 Image: researchers on a laptop; Copyright: panthermedia.net/Monkeybusiness Images

Cybersecurity: Software uncovers vulnerability

05.07.2019

Researchers at Sandia National Laboratories identified the weakness and notified the software developers. The issue has also been fixed in the latest release of the software. While no attack from this vulnerability is known, the National Institutes of Standards and Technology recently described it in a note to software developers, genomics researchers and network administrators.
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Image: doctor and assistant investigating patient`s data; Copyright: panthermedia.net/sabthai

Computer model supports cancer therapy

05.07.2019

Researchers from the Life Sciences Research Unit (LSRU) of the University of Luxembourg have developed a computer model that simulates the metabolism of cancer cells. They used the programme to investigate how combinations of drugs could be used more effectively to stop tumour growth.
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Image: schematic of stem cells; Copyright: panthermedia.net/ktsdesign

Cell therapies: homing instinct shows cells "home"

04.07.2019

In a world first, scientists have found a new way to direct stem cells to heart tissue. The findings, led by researchers at the University of Bristol and published in Chemical Science, could radically improve the treatment for cardiovascular disease.
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 Image: doctors hand on the monitoring system; Copyright: panthermedia.net/skvalval

Monitoring system: Body mapping treats damaged organs

02.07.2019

Medical advancements can come at a physical cost. Often following diagnosis and treatment for cancer and other diseases, patients' organs and cells can remain healed but damaged from the medical condition.
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Image: The BlooDe device; Copyright: Université de Franche-Comté

Haematology: problems of anti-bleeding detected in 60 mins

01.07.2019

Researchers from the Universities of Geneva and Franche-Comté have developed an innovative device that investigates a patient's platelet capacity in near real-life conditions so that bleeding can be stopped (haemostasis).
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Image: black box - new device for rapid cancer diagnosis during surgery; Copyright: Leibniz-IPHT

Optical method: compact device for rapid tissue analysis during surgery

24.06.2019

A team of researchers from Jena is presenting a groundbreaking new method for the rapid, gentle and reliable detection of tumors with laser light. For the first time, the Leibniz IPHT will present a compact device for rapid cancer diagnosis during surgery. The optical method will help surgeons to remove tumors more precisely and could make cancer operations possible without a scalpel.
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Image: Cell cultivation in a Petri dish; Copyright: panthermedia.net / matej kastelic

Organ-on-a-chip – Organs in miniature format

01.02.2019

In vitro processes and animal tests are used to develop new medications and novel therapeutic approaches. However, animal testing raises important ethical concerns. Organ-on-a-chip models promise to be a feasible alternative. In a system the size of a smartphone, organs are connected using artificial circulation.
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Image: Man and woman in a laboratory presenting a multi-organ chip; Copyright: TissUse GmbH

Multi-Organ Chips – The Patients of Tomorrow?

01.02.2019

The liver, nervous tissue or the intestines: all are important human organs that have in the past been tested for their function and compatibility using animal or in vitro test methods. In recent years, TissUse GmbH, a spin-off of the Technical University of Berlin (TU Berlin), has launched multi-organ chip platforms. But that’s not all.
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Image: Graphic rendering of several cells in a petri dish; Copyright: panthermedia.net/dani3315

Organ-on-a-chip systems: limited validity?

01.02.2019

Organ-on-a-chip systems are technically a great enhancement of medical research because they facilitate testing of active ingredients on cell cultures in the chambers of a plastic chip. This replaces animal testing and improves patient safety. That being said, they are not a true-to-life replication of the human body and can only simulate a few functions and activities.
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Photo: Preview picture of video

From algorithm to rapid test – Artificial Intelligence classifies blood cells

21.11.2018

Our blood reveals a lot about our physical health. The shape of our blood cells sheds light on several hereditary diseases for example. For a diagnosis, the cells must first be examined under the microscope and categorized into a specific cell class. We met with Dr. Stephan Quint and Alexander Kihm of the Institute of Physics at the Saarland University, who explained how this classification works.
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Image: Small brown mole on the back of a hand; Copyright: panthermedia.net/Mario Hahn

Early detection: Tattoo signals cancer – and more

09.07.2018

People who are not ill and do not show any symptoms typically do not visit the doctor. And while most people know that preventive medical checkups for cancer, for example, are important, they still avoid them. They tend to be very hesitant because the doctor might detect a serious illness. In the future, a new type of implant could make it easier to go to a screening test.
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Image: AcCellerator research device at an exhibition stand; Copyright: Daniel Klaue, ZELLMECHANIK DRESDEN GmbH

Cells in the speed trap – diagnosis in a matter of seconds

22.06.2018

A drop of blood provides a lot of valuable information. However, it takes several hours to analyze the blood of a patient and make a diagnosis. This takes away a lot of time that's crucial for treatment. A new method intends to considerably speed up this process by testing the cells in the blood in terms of their deformability and immune response.
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Image: Two hands are holding a tubular frame that is carrying a glistening wet, white tube; Copyright: Leibniz University of Hanover/Institute of Technical Chemistry

Tissue engineering: how to grow a bypass

23.04.2018

A bypass is a complicated structure. It is either made of synthetic materials that can cause blood clots and infections or created by using the patient’s veins. However, the latter often does not yield adequate material. A newly developed bioreactor could solve this problem in the future. It is designed to tissue engineer vascular grafts by using the body’s own material.
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Image: yellow tape measure with capsules in front of it; Copyright: panthermedia.net/Jiri Hera

Personalized cancer medicine: customized treatment

01.03.2018

Everyone is different. This statement also applies to our health. Cancer, in particular, can look and progress differently depending on the individual person. That’s why every patient ideally also needs a customized treatment that is tailored to their individual needs. But how feasible is this idea?
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Image: a container with the nutrient medium for cancer cells; Copyright: Dr. Markus Wehland

Cells in space – extraterrestrial approaches in cancer research

22.02.2018

Here on Earth, all experiments are bound by gravitation. Yet, freed from gravity's grip, tumor cells, for example, behave in an entirely different way. As part of the "Thyroid Cancer Cells in Space" project by the University of Magdeburg, smartphone-sized containers carrying poorly differentiated thyroid cancer cells are sent into space.
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Image:

"Spray-On" muscle fibers for biomimetic surfaces

08.01.2018

Few patients with heart failure are fortunate enough to receive a donor's heart. Ventricular assist devices (or heart pumps) have been around for several years and are designed to buy time as patients wait for a transplant. Unfortunately, the body doesn't always tolerate these devices.
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Image: interferometric detection of scattered light, iSCAT; Copyright: MPL

Interface between Physics and Medicine: new interdisciplinary center

22.08.2017

Physics has always supported medical science, especially when it comes to practical implementation. Now physicists and health professionals join in collaborative research at an interdisciplinary Center in Erlangen and incorporate fundamental principles of theoretical physics in their studies of diseases.
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Image: blood is taken from a finger and analysed by a blood testing device; Copyright:hes_so_valais_wallis

Without any delay: drug dose adjustment at the point of care

01.08.2017

Many therapeutic drugs are very powerful, but they are also very toxic at the same time. Thus, they have to be measured regularly, again and again, so that an adjustment of the individual drug dosage can be made. Until now, the "normal" way was to take the blood sample, send it to a central laboratory and get the results after some days. A new point-of-care test can measure it in 15 minutes.
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Image: Preview picture of video

Light microscope ChipScope - a glimpse into living cells

14.07.2017

A microscope that is only a few millimeters in size and that can help to consider cell changes in real time. This is the goal of the EU project ChipScope. Scientists led by Dr. Hutomo Wasisto in Braunschweig help to make this project come true.
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Image: An eye surgeon and an assistant are treating a patient with a surgical laser; Copyright: University Hospital Dresden/Felix Koopmann

Eye surgery: precision and prevention with femtosecond lasers

03.07.2017

Precision work is absolutely essential in eye surgery since the surgical site is very minute and sensitive. This is why eye surgeons have been using lasers for years. Femtosecond lasers are especially well suited to serve this purpose because they are able to cut tissue with great precision and little energy, which prevents unwanted side effects of surgery.
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