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Image: A researcher displays the pliability of a trileaf heart valve bioprinted in collagen.; Copyright: Carnegie Mellon University College of Engineering

Tissue engineering: 3D printing the human heart

05.08.2019

A team of researchers from Carnegie Mellon University has published a paper in Science that details a new technique allowing anyone to 3D bioprint tissue scaffolds out of collagen, the major structural protein in the human body. This first-of-its-kind method brings the field of tissue engineering one step closer to being able to 3D print a full-sized, adult human heart.
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Image: Bacteria in the gut are pulled into the helical channels by an osmotic 'pump' in the pill.; Copyright: Nano Lab, Tufts University

Diagnostics: 3D-printed pill samples aid diagnosis and treatment

29.07.2019

The pill is the first known working device capable of non-invasively and accurately assessing the profile of bacterial species inhabiting any stage of the gastrointestinal tract. The ability to profile bacterial species inhabiting the gut could have important implications for conditions that affect and are affected by the intestinal microbiome.
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Image: microrobots; Copyright: Caltech

Microsurgical instruments: microrobots for treating tumors

26.07.2019

Targeting medical treatment is a practice as old as medicine itself. But what is inside the body, is not so easy to reach. In such cases, a treatment like surgery might be called for. Researchers in Caltech's Division of Engineering and Applied Science are working on microrobots that can deliver drugs to specific spots inside the body while being monitored and controlled from outside the body.
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Image: young woman in the laboratory loading MiniON by injecting something in it; Copyright: Quadram Institute

Rapid test: diagnosing pneumonia and other lower respiratory infections

09.07.2019

Scientists at the Quadram Institute and the University of East Anglia (UEA) have developed a new, rapid way of diagnosing bacterial lower respiratory tract infections in hours rather than days, that could improve patient care and slow the spread of antimicrobial resistance. The method is published today in the journal Nature Biotechnology.
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Image: elderly man in the lab injecting a liquid into a chip; Copyright: panthermedia.net/matej kastelic

Human-on-a-chip: prediction of in vivo results based on in vitro model

08.07.2019

Hesperos Inc., pioneers of the human-on-a-chip in vitro system has announced the use of its innovative multi-organ model to successfully measure the concentration and metabolism of two known cardiotoxic small molecules over time, to accurately describe the drug behavior and toxic effects in vivo. The findings support the potential of body-on-a-chip systems to transform the drug discovery process.
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Image: doctor in laboratory investigates medical samples of a patient; Copyright: panthermedia.net/Arne Trautmann

Biomarker: test improves prostate cancer detection

03.07.2019

A team of researchers from UCLA and the University of Toronto have identified a new biomarker found in urine that can help detect aggressive prostate cancer, potentially saving hundreds of thousands of men each year from undergoing unnecessary surgeries and radiotherapy treatments.
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 Image: doctors hand on the monitoring system; Copyright: panthermedia.net/skvalval

Monitoring system: Body mapping treats damaged organs

02.07.2019

Medical advancements can come at a physical cost. Often following diagnosis and treatment for cancer and other diseases, patients' organs and cells can remain healed but damaged from the medical condition.
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Image: cells are placed on a microfluidic organ-chip; Copyright: Dr. Gad Vatine/BGU

Blood-brain barrier chip: using stem cells for the first time

18.06.2019

Researchers at Ben-Gurion University of the Negev (BGU) and Cedars-Sinai Medical Center in Los Angeles have, for the first time, duplicated a patient's blood-brain barrier (BBB), creating a human BBB chip with stem cells, which can be used to develop personalized medicine and new techniques to research brain disorders.
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Image: microscope images of the human Blood-Brain Barrier-on-Chip; Copyright: Wyss Institute at Harvard University

Blood-Brain Barrier Chip: in vivo-like drug and antibody transport

17.06.2019

Like airport security barriers that either clear authorized travelers or block unauthorized travelers and their luggage from accessing central operation areas, the blood-brain-barrier (BBB) tightly controls the transport of essential nutrients and energy metabolites into the brain and staves off unwanted substances circulating in the blood stream.
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Image: Woman undergoing a CT scan; Copyright: panthermedia.net/Tyler Olsonv

Machine learning: superior results for low-dose CT

12.06.2019

Machine learning has the potential to vastly advance medical imaging, particularly computerized tomography (CT) scanning, by reducing radiation exposure and improving image quality. Those new research findings were just published in Nature Machine Intelligence by engineers at Rensselaer Polytechnic Institute and radiologists at Massachusetts General Hospital and Harvard Medical School.
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Image: Laboratory tests to identify cancer cells; Copyright: panthermedia.net/Sven Hoppe

Biomarker: Which pancreatic cysts may become cancerous?

10.06.2019

Cysts in the pancreas sometimes develop into the invasive cancer, depending on the type of cyst, but such growths often are not cancerous, creating a quandary for physicians who spot them via CT and MRI scans. Surgery to remove pancreatic cysts is often complex, so there is a need for new tools to identify which such cysts are most likely to develop into cancer and which are not.
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Image: A coloured microscopic image of an organoid; Copyright: Cincinnati Children's

Organ-on-a-chip: Bioengineered human liver disease

04.06.2019

Scientists successfully bioengineered human liver organoids that faithfully mimic key features of fatal liver disease in the laboratory. This allowed them to uncover underlying disease biology in the organoids and test a potential therapy that in preclinical lab tests reversed an often-fatal childhood condition called Wolman disease.
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Image: illustration of the production of tissues and organs with lithography; Copyright: F. Pampaloni, BRIGHTER, 2019

Tissue Engineering: producing tissue and organs through lithography

28.05.2019

The production of artificial organs is a hot research topic. In the near future, artificial organs will compensate for the lack of organ donations and replace animal experiments. Although there are already promising experiments with 3D printers that use a "bio-ink" containing living cells, a functional organ has never been created in this way.
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Image: blood sample tubes; Copyright: panthermedia.net / scanrail

Blood test: How effective is stem cell transplantation?

24.05.2019

University of Maryland School of Medicine study shows the potential of transplanted stem cell secretions as a liquid biopsy.
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 Image: Abdelrasoul leads the research team of University of Saskatchewan; Copyright: Daniel Hallen, University of Saskatchewan

Wearables: World's first wearable kidney

23.05.2019

An artificial portable kidney that patients who have suffered renal failure could wear is to be created by a research team at the University of Saskatchewan with federal funding.
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Image: Lung monitoring of a patient with PulmoVista 500 by Draeger; Copyright: Drägerwerk AG & Co. KGaA

Restoring Pulmonary Function

01.03.2019

People suffering from lung disease temporarily need ventilator support because they are unable to breathe naturally. Mechanical ventilation is designed to ensure the survival of these patients. The goal is to adapt the ventilator settings and tailor them the patient's specific needs and prevent lung tissue damage.
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Image: Preemie doll with drug delivery system on the nose; Copyright: Fraunhofer ITEM/Till Holland

Gentle medication for the little ones – with every breath

22.02.2019

According to the WHO, ten percent of babies worldwide are born prematurely. Since most organs of these tiny babies have not fully developed yet, it can quickly lead to complications and disorders and most notably affect the lungs of the premature infants. What's more, infections require gentle treatment, as the preemies themselves are fragile and susceptible – making this a challenging situation.
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Image: Cell cultivation in a Petri dish; Copyright: panthermedia.net / matej kastelic

Organ-on-a-chip – Organs in miniature format

01.02.2019

In vitro processes and animal tests are used to develop new medications and novel therapeutic approaches. However, animal testing raises important ethical concerns. Organ-on-a-chip models promise to be a feasible alternative. In a system the size of a smartphone, organs are connected using artificial circulation.
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Image: Man and woman in a laboratory presenting a multi-organ chip; Copyright: TissUse GmbH

Multi-Organ Chips – The Patients of Tomorrow?

01.02.2019

The liver, nervous tissue or the intestines: all are important human organs that have in the past been tested for their function and compatibility using animal or in vitro test methods. In recent years, TissUse GmbH, a spin-off of the Technical University of Berlin (TU Berlin), has launched multi-organ chip platforms. But that’s not all.
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Image: Woman at her desk holding her back; Copyright: panthermedia.net/Andrey Popov

AI ensures dynamic sitting

22.01.2019

Whether in the office, at school or behind the wheel: we spend a lot of time sitting and often stay in the same position for too long. The possible side effects are stiffness, back problems and pain. The SensA-Chair smart seating solution combats decreased mobility and ensures dynamic sitting.
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Image:Lung; Copyright: panthermedia.net/CLIPAREA

Lung Imaging – Keeping the Respiratory System Healthy

05.10.2018

Many people have damaged or suboptimally functioning lungs. An accurate diagnosis and subsequent treatment are vital to protect this life-sustaining organ. Modern imaging solutions help physicians and patients understand what happens inside the lungs.
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Image: View over the shoulders of two doctors at a screen showing a model of a heart; Copyright: panthermedia.net/Wavebreakmedia ltd

Regenerative heart valves: from simulation to replacement

23.07.2018

Every year, more than 250,000 patients worldwide receive heart valve implants. Children require repeated replacement surgery because their bodies are still growing, the prosthetic heart valves are not. Regenerative heart valves solve this problem. Until now, we have only been able to monitor how these living implants develop in the body after the fact. Computer models now make this predictable.
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Image: two men in the laboratory next to the Organ Care System with a pig's lung inside; Copyright: Kaiser/MHH

Organ Care System: treatment under extreme conditions

08.05.2018

Multidrug-resistant organisms that are treated with a dosage that exceeds the regular dose a hundred times and at temperatures of over 40 degrees Celsius – the human organism is unable to handle it. Yet if the diseased organ is treated outside of the body, extreme conditions are an option. For the first time, physicians have succeeded in treating a severe case of pneumonia by using the OCS.
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Image: Photograph of hands with hyperspectral imaging; Copyright: Diaspective Vision GmbH

Precision surgery thanks to informative hyperspectral imaging

08.02.2018

When body tissue is reconnected during a tumor operation in the gastrointestinal tract, surgeons need information about the current state of these so-called anastomoses. The new, non-invasive hyperspectral imaging technology now makes it possible to measure the crucial parameters during surgery and thereby increase surgical precision.
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Image: Surgeons during surgery; Copyright: UKR

Acute kidney injury: Early detection thanks to biomarker

08.11.2017

Major surgeries in the abdominal region often result in kidney injury in patients. Meanwhile, the clinical manifestations don't present until one or two days after the procedure. This causes physicians to lose valuable time to treat patients. The University Hospital Regensburg has researched a new concept for the treatment of kidney injuries for several years.
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Image: Preview picture of video

A look at the medicine of tomorrow – At MEDICA Preview in Hamburg

08.11.2017

Every year in September, MEDICA Preview takes place at the University Hospital Hamburg-Eppendorf. It is intended to give visitors, exhibitors and the trade press a foretaste of MEDICA in November and tomorrow's medicine. This year, we were on the scene with our camera to learn more about opto genetics, smart hospitals and the support of patients with multiple organ failure.
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Image: A women with a bald head and a headscarf, smiling, sitting on a sofa talking ot another woman; Copyright:Katharina Bia asiewic

Irreversible Electroporation – Last hope for liver cancer patients

24.04.2017

Liver cancer is the fifth most common malignant tumor in the world. The tumor can be removed through surgery or by utilizing thermal ablation techniques. If a treatment with conservative methods is no longer possible, there is an alternative: irreversible electroporation (IRE). The effectiveness of this method was now confirmed by a clinical study.
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