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Image: scanning electron microscope image of NETs; Copyright: Urban, et al., Max Planck Institute

Machine learning: to measure inflammation process

13.12.2019

UNC School of Medicine researchers created an artificial intelligence tool to measure NETosis, an inflammatory process where white blood cells trap invaders; this work will help scientists find ways to stop or promote NETosis in disease states
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Image: depiction of a disruption of immune cells; Copyright: Gerrit Müller/Freie Universität Berlin

Immunology: why beta-blockers cause skin inflammation

08.11.2019

Beta-blockers are often used to treat high blood pressure and other cardiovascular diseases. However, in some patients they can trigger or exacerbate psoriasis, an inflammatory skin disease. Scientists at the University of Bonn and Freie Universität Berlin have now found a possible cause for this. Their results have been published in the renowned journal "Autophagy".
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Image: depiction of cells; Copyright: Yu Jung Shin

Cells: oxygen-starved tumor cells promoting cancer spread

08.11.2019

Using cells from human breast cancers and mouse breast cancer models, researchers at the Johns Hopkins Kimmel Cancer Center say they have significant new evidence that tumor cells exposed to low-oxygen conditions have an advantage when it comes to invading and surviving in the bloodstream.
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Image: Flags are blowing in the wind to the backdrop of a dark evening sky; Copyright: Messe Düsseldorf/ctillmann

Medicine at the pulse of time: Innovations and trends at MEDICA 2019

04.11.2019

Soon, the world's largest trade fair for medical technology will open its doors again: More than 5.000 exhibitors will present their newest products and ideas at MEDICA from 18 to 21 November. You will not only meet well-known companies here, but also lots of young start-ups. Or, you can visit the MEDICA forums and conferences to experience a rich program of lectures and discussions.
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Image: malaria infected blood cells under a microscope; Copyright: S. Kapishnikov

Microscope: malaria pathogen under X-ray

31.10.2019

Around 40 percent of humanity lives in regions affected by malaria, around 200 million people contract the disease every year, and an estimated 600,000 people die as a result. These pathogens are unicellular organisms that settle inside the red blood cells of their hosts and metabolize hemoglobin there to grow and multiply.
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Image: molecular simulation close-up; Copyright: Chan Cao, EPFL

Biosensor: made from a dangerous toxin

30.10.2019

Some types of bacteria have the ability to punch holes into other cells and kill them. They do this by releasing specialized proteins called "pore-forming toxins" (PFTs) that latch onto the cell's membrane and form a tube-like channel that goes through it. This hole across the membrane is called a pore. Punctured by multiple PFTs, the target cell self-destructs.
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Image: a protein adapter in the blood stream; Copyright: MPI-P

Cells: toxin, trauma, therapy?

28.10.2019

The department of Prof. Tanja Weil at the Max Planck Institute for Polymer Research has, in cooperation with the group of Prof. Holger Barth from the Institute of Pharmacology and Toxicology at the Ulm University, shown in initial laboratory tests that they are able to specifically modulate processes in human white blood cells in vitro.
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Image: Brown cancer cells with other blue cell types in a schematic depiction; Copyright: Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine

Radiotherapy: breaking the stroma barrier

22.10.2019

Pancreatic cancer is one of the leading causes of cancer related deaths worldwide. Patients with pancreatic cancer often receive chemotherapy or radiation therapy, which are not always effective and can have toxic side effects. The method may offer an effective treatment for pancreatic cancer with fewer side effects in surrounding organs.
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Image: model image of pathogens; Copyright: Sebastian Geibel

Pathogens: new insights in tuberculosis

10.10.2019

Researchers at the University of Würzburg and the Spanish Cancer Research Centre have gained new insights into the pathogen that causes tuberculosis. The work published in Nature provides the basis for a new approach in antibiotic therapy.
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Image: immunofluorescence of spleen sections of a mice; Copyright: IMP

Pathogens: a mechanism to control autoimmunity

08.10.2019

The immune system relies on B cells and their ability to make antibodies against an extremely broad range of pathogens. This broad responsiveness bears some risk, as B cells can also turn against healthy tissue - a phenomenon called autoimmunity.
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Image: cells devouring tumor cells under a microscope; Copyright: Dr Fotini Vogiatzi

Immunotherapy: a promising antibody

07.10.2019

Acute lymphoblastic leukaemia (ALL) is the most common cancer in children. This form of blood cancer is caused by malignant abnormal precursor cells of certain white blood cells, and usually leads to a rapidly progressive reduction of bone marrow function, and thus impaired blood formation.
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Image: bacterial syringe structure on a black background; Copyright: Shikuma Lab

Bacteriology: structures can be tapped to deliver drugs

19.09.2019

Not all bacteria spread diseases, many are beneficial and this strain has nanoscale syringes that deliver proteins which cause metamorphosis in marine animals, and could be modified as a novel drug delivery tool for future vaccines and cancer care.
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Image: Two petri dishes with different kinds of agar plates on which bacterial cultures are growing; Copyright: panthermedia.net/photographee.eu

Antibiotic resistance: technical tricks against pathogens

01.08.2019

An untreatable infection is a nightmare for physicians and potentially life-threatening to the patient. Unfortunately, more and more pathogens emerge that are resistant to drugs, especially antibiotics. We need to use our drugs smartly and come up with technical solutions as well to prevent our weapons from blunting in the future.
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Image: A lab technician is using a pipette to fill a solution into a petri dish; Copyright: panthermedia.net/Arne Trautmann

Last-resort antibiotics: "We can identify carbapenemases within half an hour"

01.08.2019

Antibiotic resistance is modern medicine's greatest challenge. Some bacteria only respond to a handful of antibiotics, prompting hospitals to spend a lot of time finding an effective drug. That’s why it is critical for physicians to rapidly identify antibiotic resistance to avoid ineffective treatments.
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Image: A greenly lit laboratory device; Copyright: Sven Döring

Photonics: "We want a rapid and easy method to identify pathogens and antibiotic resistance"

01.08.2019

The medical devices value chain has gaps between academic research and industrial practice that slow down innovation processes. This also applies to time-sensitive and urgently needed products such as rapid diagnostic tests to identify resistant pathogens. At the InfectoGnostics Research Campus in Jena, partners from research and medicine team up to close these gaps.
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Image: A man is holding a hand full of pill blisters with antibiotics; Copyright: panthermedia.net/alexkalina

Combating antibiotic resistance: One step ahead through technology

01.08.2019

Antibiotic resistance is on the rise in all parts of the world, complicating medical treatment of serious bacterial infections in patients. The World Health Organization estimates that approximately 33,000 people die each year from antibiotic-resistant bacteria in Europe alone. Bacteria that are resistant to multiple or even all known antibiotics pose an ever-increasing threat.
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Image: Preview picture to the video

Company anniversary at MEDICA – Interview with the Dr. Schumacher GmbH

15.11.2018

The Dr. Schumacher GmbH was able to celebrate its 40th anniversary at MEDICA 2018. We used this opportunity for a short talk with the managing directors about the company's history, MEDICA and how hygiene in hospitals and physicians' offices can be ensured.
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Image: AcCellerator research device at an exhibition stand; Copyright: Daniel Klaue, ZELLMECHANIK DRESDEN GmbH

Cells in the speed trap – diagnosis in a matter of seconds

22.06.2018

A drop of blood provides a lot of valuable information. However, it takes several hours to analyze the blood of a patient and make a diagnosis. This takes away a lot of time that's crucial for treatment. A new method intends to considerably speed up this process by testing the cells in the blood in terms of their deformability and immune response.
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Image: two men in the laboratory next to the Organ Care System with a pig's lung inside; Copyright: Kaiser/MHH

Organ Care System: treatment under extreme conditions

08.05.2018

Multidrug-resistant organisms that are treated with a dosage that exceeds the regular dose a hundred times and at temperatures of over 40 degrees Celsius – the human organism is unable to handle it. Yet if the diseased organ is treated outside of the body, extreme conditions are an option. For the first time, physicians have succeeded in treating a severe case of pneumonia by using the OCS.
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Image: Collage of several MRI images of the heart, in which different locations are marked with red arrows; Copyright: University Hospital Münster/Ali Yilmaz

Myocarditis: more specific diagnosis thanks to molecular imaging

01.09.2017

There are many causes of myocarditis or inflammation of the heart muscle. Oftentimes, the culprits are viruses or bacteria and sometimes even an acute heart attack. Regardless of the cause, it creates a challenge for cardiologists: a diagnosis tends to be only nonspecific without a biopsy. A cardiac MRI and molecular imaging promise to provide assistance.
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Image: Demonstrator; Copyright: Leibniz-IPHT

Medical imaging is onto septic fungi

03.04.2017

Instant treatment is absolute vital for patients developing sepsis. Providing a specific therapy early on is key. To manage this the pathogenic organisms need to be identified accurately. But a fungal sepsis can still be a hard nut to crack.
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Image: A petri dish with yellow bacterial cultures on a black ground; Copyright: panthermedia.net/kwanchaichaiudom

Laboratory medicine: confronting infections with speed and foresight

03.04.2017

The laboratory is one of the most important and pivotal bastions in patient care. In the laboratory, acute, chronic and genetic diseases are diagnosed, the progression of diseases such as diabetes is regularly checked or specialists look for biomarkers to adapt cancer therapies.
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Image: Single room with a window in a hospital; Copyright: panthermedia.net/epstock

Hospital construction: infection prevention through architecture?

09.01.2017

Hospitals apply many infection prevention and control measures. They all have one thing in common: they are individual parts of an overall concept that is aimed at preventing the spread of highly infectious and resistant pathogens in hospitals. Nevertheless, previous hygiene concepts ignore one aspect of hospitals: the architecture of the actual hospital facility itself.
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