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Bild: A man with brown hair, Dr. Dr. René Hägerling, poses for the camera; Copyright: BIH/David Ausserhofer

BIH/David Ausserhofer

ERC Starting Grant: Why do blood and lymphatic vessels grow unchecked?


Anomalies in the formation of blood and lymphatic vessels are, thankfully, rare. Those who do have them face a lifetime of complications that can range from the mild to the life-threatening. To date, little is known about the causes, which means the diagnostic and treatment options are very limited. René Hägerling of the BIH Center for Regenerative Therapies has made it his mission to remedy this.
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Image: 3D illustration. Colorful DNA molecule. Conceptual image of a structure of the genetic code; Copyright: ktsimage


Sinonasal cancer: AI facilitates breakthrough in diagnostics


Researchers at LMU and Charité hospital in Berlin have developed a method for classifying difficult-to-diagnose nasal cavity tumors.
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Image: Close-up of a male chest-shoulder area with a tattoo-like drawing on the skin that is supposed to represent a gene cluster; Copyright: Polygraph Design

Polygraph Design

How genes and small molecules influence personal disease risk


In an international collaboration with partners from Cambridge (UK), scientists from the Berlin Institute of Health at the Charité (BIH) have now discovered more than 300 regions in the genome that contribute to this individual chemical fingerprint. They have now published their results in Nature Medicine.
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Image: A man in a suit and tie stands in front of a building and smiles at the camera; Copyright: RCSI University of Medicine and Health Sciences

RCSI University of Medicine and Health Sciences

Genomic Data Infrastructure Ireland project to support discovery of genetic disease causes


RCSI University of Medicine and Health Sciences and FutureNeuro are co-leading, with University College Dublin, the Irish element of a new EU project to support the integration of genomics into healthcare and advance new treatments for patients.
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Image: 3D illustration of a DNA molecule on a blue background; Copyright: mahirkart


Rare cancers: early detection of hereditary cancer risk


Hereditary genetic mutations play an important role in oncogenesis, but they usually remain undetected.
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Image: Close-up of a hand in a blue laboratory glove putting a sample of blood under a microscope; Copyright: prostooleh


New initiative to INDICATE cancer risks


INDICATE, an international collaborative initiative to unravel the role of the Human Leukocyte Antigen type as risk modifier in individuals with a genetic cancer predisposition.
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Image: Close-up of a hand in a blue laboratory glove using a pipette to fill samples into a row of micro test tubes; Copyright: sommthink/Shutterstock


Head and neck cancer: Markers to facilitate better treatment in the future


Malignant tumours in the head and neck region are very heterogeneous and therefore difficult to treat. A joint study by MedUni Vienna and the Christian Doppler Laboratory for Applied Metabolomics focused on the development and identification of specific markers to improve risk assessment for patients.
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Image: Endoscopic examination during surgery; Copyright: Yakov_Oskanov


Using AI during cancer-screening results in more recommended controls


Patients with polyps have a higher risk of evolving cancer in the future. Using Artificial intelligence (AI) during colonoscopy can be useful to detect pre-cancerous polyps, Yuichi Mori, doctor and associate professor from the Clinical Effectiveness Research group at the University of Oslo says.
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Image: Brain surgeon examining a brain via 3D imaging on a monitor; Copyright: DC_Studio


Project GLADIATOR - New technologies for cancer monitoring and therapy


The Fraunhofer Institute for Biomedical Engineering IBMT is contributing its expertise in the field of medical biotechnology and ultrasound to an EC project to work on the next generation of theranostics for brain pathologies using autonomous externally controllable nanonetworks.
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Image: Long structure of DNA double helix shown in dept; Copyright: ktsimage


Ten new risk genes for Crohn's disease


The results of the international study involving the Cluster of Excellence PMI also point to a previously unknown process in the development of this chronic inflammatory bowel disease.
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Image: Electron microscopic image of Mycobacterium tuberculosis; Copyright: 4.0/Finci, I. et al.

4.0/Finci, I. et al.

Personalised antibiotic treatment strategies for tuberculosis patients


In an international study presented in the journal Lancet Microbe, DZIF researchers have now succeeded in identifying patient-specific resistance patterns using a bacterial genome analysis technique.
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Image: A woman in a blue blazer, senior author Dr. Deb Schrag, poses for the camera; Copyright: European Society for Medical Oncology

European Society for Medical Oncology

New era of early cancer detection with blood test


New data supporting the accuracy of multi-cancer early detection (MCED) blood testing, have major implications for future cancer care provision.
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Image: Microscope in biotechnology laboratory with laboratory samples in the background; Copyright: ckstockphoto


Machine learning to unlock genomic code in clinical cancer samples


A new paper from University of Helsinki, published in Nature Communications, suggests a method for accurately analysing genomics data in cancer archival biopsies.
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Image: Happy young woman showing positive pregnancy test to her husband in bedroom; Copyright: Prostock-studio


Genetic testing before pregnancy detects up to half of risk


In the USA, doctors recommend that couples have genetic screening before trying to conceive. Researchers at the University of Zurich have now shown that a maximal variant of this test detects the risk in 44 percent of couples who are related by blood, and in just 5 percent of other couples.
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Image: A lab technician is using a pipette to fill a solution into a petri dish; Copyright: Trautmann

Last-resort antibiotics: "We can identify carbapenemases within half an hour"


Antibiotic resistance is modern medicine's greatest challenge. Some bacteria only respond to a handful of antibiotics, prompting hospitals to spend a lot of time finding an effective drug. That’s why it is critical for physicians to rapidly identify antibiotic resistance to avoid ineffective treatments.
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