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Immunotherapy: novel technique for cancer treatment
15.10.2019
Immunotherapy is a promising cancer treatment that uses genetically modified immune cells to fight cancer. It can be used as a primary treatment or in combination with other treatments such as radiation and chemotherapy to slow down or stop the growth of cancer cells and prevent them from spreading to other parts of the body.
Cells: potential liver cancer treatment
10.10.2019
Liver cancer is the second leading cause of cancer-related deaths worldwide. The most common primary liver cancer in adults is known as hepatocellular carcinoma (HCC), and accounts for approximately 780.000 deaths every year. Even with advanced surgical treatments or transplantation, the 5-year survival rate for HCC patients remains poor due to frequent recurrence.
Pathogens: new insights in tuberculosis
10.10.2019
Researchers at the University of Würzburg and the Spanish Cancer Research Centre have gained new insights into the pathogen that causes tuberculosis. The work published in Nature provides the basis for a new approach in antibiotic therapy.
Pathogens: a mechanism to control autoimmunity
08.10.2019
The immune system relies on B cells and their ability to make antibodies against an extremely broad range of pathogens. This broad responsiveness bears some risk, as B cells can also turn against healthy tissue - a phenomenon called autoimmunity.
Cells: mechanism for the formation of new blood vessels
24.09.2019
Researchers from Uppsala University have revealed for the first time a mechanism for how new blood vessels are formed and have shown the importance of this mechanism for embryo survival and organ function. The results could be developed to control the formation of new blood vessels in different diseases. The new study is published in the journal EMBO Reports.
DNA: held together by hydrophobic forces
23.09.2019
Researchers at Chalmers University of Technology, Sweden, disprove the prevailing theory of how DNA binds itself. It is not, as is generally believed, hydrogen bonds which bind together the two sides of the DNA structure. Instead, water is the key. The discovery opens doors for new understanding in research in medicine and life sciences. The researchers' findings are presented in the journal PNAS.
Nanotechnology: nanomedicine for efficient chemotherapy
23.09.2019
Researchers at the University of Helsinki in collaboration with researchers from Åbo Akademi University,Finland and Huazhong University of Science and Technology,China have developed a new anti-cancer nanomedicine for targeted cancer chemotherapy. This new nano-tool provides a new approach to use cell-based nanomedicines for effcient cancer chemotherapy.
Bacteriology: structures can be tapped to deliver drugs
19.09.2019
Not all bacteria spread diseases, many are beneficial and this strain has nanoscale syringes that deliver proteins which cause metamorphosis in marine animals, and could be modified as a novel drug delivery tool for future vaccines and cancer care.
Genetics: cardiac fibrosis study identifies key proteins
13.09.2019
Using cutting-edge technologies, researchers at Duke-NUS Medical School, Singapore, have developed the first genome-wide dataset on protein translation during fibroblast activation, revealing a network of RNA-binding proteins (RBPs) that play a key role in the formation of disease-causing fibrous tissue in the heart.
Genetics: women's deep belly fat strongly linked to diabetes
12.09.2019
A comprehensive study from Uppsala University, with over 325,000 participants, shows that deep belly fat is a major contributing risk factor for developing diabetes and cardiovascular disease. Moreover, the scientists investigated how our genes affect the accumulation of fat and present a new, simpler method to estimate the amount of deep belly fat.
DNA: construction kit replaces expensive antibody medication
11.09.2019
Researchers at KU Leuven in Belgium have developed a technique to make sheep produce new antibodies simply by injecting the DNA building blocks. This approach is much cheaper and more efficient than producing antibodies industrially and administering them afterwards. The study in animals with a similar size as humans brings us a step closer to the clinical use of antibody gene therapy.
Analyzing systems: technique stores cellular 'memory' in DNA
29.08.2019
Engineers program human and bacterial cells to keep a record of complex molecular events. Using a technique that can precisely edit DNA bases, MIT researchers have created a way to store complex "memories" in the DNA of living cells, including human cells.
Laboratory medicine: biomaterials smarten up with CRISPR
23.08.2019
The CRISPR-Cas system has become the go-to tool for researchers who study genes in an ever-growing list of organisms, and is being used to develop new gene therapies that potentially can correct a defect at a single nucleotide position of the vast reaches of the genome.
Shedding light on PUVA light therapy for skin diseases
22.08.2019
Together with their Munich-based colleagues, a team of physical chemists from Heinrich Heine University Düsseldorf (HHU) has clarified which chemical reactions take place during PUVA therapy. The therapy involves light-induced damage to the DNA of diseased cells. The team working under Prof. Peter Gilch has now published its findings in the Journal of the American Chemical Society.
Biomarker: health indication in old age
21.08.2019
Researchers on ageing from the Max Planck Institute for Biology of Ageing and the Leiden University Medical Center (LUMC) collaborate to link basic insights from model organisms to the causes of ageing in humans. They can determine the disease vulnerability of older people using a defined set of substances in the blood.
Last-resort antibiotics: "We can identify carbapenemases within half an hour"
01.08.2019
Antibiotic resistance is modern medicine's greatest challenge. Some bacteria only respond to a handful of antibiotics, prompting hospitals to spend a lot of time finding an effective drug. That’s why it is critical for physicians to rapidly identify antibiotic resistance to avoid ineffective treatments.
Software: better determination for macromolecular structures
25.07.2019
The structures of proteins, RNA and DNA are the key to our understanding of life. These structures are measured with X-ray or neutron diffraction, but the data are rarely perfect. Researchers at the University of Würzburg are now developing a new software to analyse this data.
Interview with Hombrechtikon Systems Engineering AG
15.11.2018
Whether DNA testing, tissue analysis or blood tests – the secrets of life are unraveled in the laboratory. In order to master this challenge, all processes must first be optimized and automated. Which role HSE AG plays here, the Swiss company explains at MEDICA 2018.
On the trail of cancer: personalized cancer vaccine
01.03.2018
Conventional cancer treatment selection typically depends on the location of the tumor. However, this approach ignores the distinct gene mutations in the tumor of the individual patient. New cancer research approaches increasingly emphasize the concept of personalized therapy.
Personalized medicine: a paradigm shift is gaining momentum
01.03.2018
Personalized medicine does not follow a "one-size-fits-all" treatment approach but emphasizes a "tailor-made" paradigm, meaning a treatment is customized to each individual person's case. For patients, this increases the chances of treatment success and means fewer side effects. While the approach originates in the field of oncology, it is now also increasingly applied to other disease patterns.
Collect Data? Utilize Data! – The Blessings of Big Data
01.03.2017
Genome data, MRI images, and blood test results – data collected in the medical sector is not only very heterogeneous but also extremely extensive. However, it is important to not only collect this data but to also utilize it. After all, processed, linked and analyzed data provides many opportunities in research, hospital management and ultimately also for the individual patient.
Ophthalmology today and tomorrow: surgery and more
01.02.2017
Ophthalmology procedures and eye surgeries have been around since ancient times. Today we can hardly imagine the types of circumstances that surrounded any surgical procedures to our perhaps most important sense organ in those days and later eras. Meanwhile, the present and future of this medical specialty looks all the more promising.
Gene therapy for the treatment of achromatopsia
01.02.2017
Achromatopsia is a rare hereditary visual disorder. Along with total color blindness, patients most notably suffer from reduced visual acuity and increased sensitivity to light and glare.