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Last-resort antibiotics: "We can identify carbapenemases within half an hour"
01.08.2019
Antibiotic resistance is modern medicine's greatest challenge. Some bacteria only respond to a handful of antibiotics, prompting hospitals to spend a lot of time finding an effective drug. That’s why it is critical for physicians to rapidly identify antibiotic resistance to avoid ineffective treatments.
Diagnostics: Animal blood samples help predict human diseases
17.07.2019
Penguins, Asian elephants and many other animal species live in the zoos of Saarbrücken and Neunkirchen. As they come from different continents, blood is regularly taken from the animals to check their health.
Laboratory medicine: engineers revolutionize molecular microscopy
15.07.2019
Control Engineers of the Otto von Guericke University Magdeburg, in collaboration with colleagues from the Jülich Research Center, have developed a method for measuring the electrical potentials of molecules and molecular surfaces with previously unattainable precision and speed.
Rapid test: diagnosing pneumonia and other lower respiratory infections
09.07.2019
Scientists at the Quadram Institute and the University of East Anglia (UEA) have developed a new, rapid way of diagnosing bacterial lower respiratory tract infections in hours rather than days, that could improve patient care and slow the spread of antimicrobial resistance. The method is published today in the journal Nature Biotechnology.
Diagnostics: A rapid, easy-to-use DNA amplification method
19.06.2019
Scientists in Japan have developed a way of amplifying DNA on a scale suitable for use in the emerging fields of DNA-based computing and molecular robotics. By enabling highly sensitive nucleic acid detection, their method could improve disease diagnostics and accelerate the development of biosensors, for example, for food and environmental applications.
Blood-brain barrier chip: using stem cells for the first time
18.06.2019
Researchers at Ben-Gurion University of the Negev (BGU) and Cedars-Sinai Medical Center in Los Angeles have, for the first time, duplicated a patient's blood-brain barrier (BBB), creating a human BBB chip with stem cells, which can be used to develop personalized medicine and new techniques to research brain disorders.
Blood-Brain Barrier Chip: in vivo-like drug and antibody transport
17.06.2019
Like airport security barriers that either clear authorized travelers or block unauthorized travelers and their luggage from accessing central operation areas, the blood-brain-barrier (BBB) tightly controls the transport of essential nutrients and energy metabolites into the brain and staves off unwanted substances circulating in the blood stream.
Advance in genome analysis: DNA tests for patients move closer
05.06.2019
Diseases caused by genetic changes could be detected more readily thanks to an advance in DNA analysis software. The development will make it easier to integrate genetic testing into health care systems such as the UK's National Health Service, which cares for around three million people affected by genetic diseases in the UK.
Organ-on-a-chip: Bioengineered human liver disease
04.06.2019
Scientists successfully bioengineered human liver organoids that faithfully mimic key features of fatal liver disease in the laboratory. This allowed them to uncover underlying disease biology in the organoids and test a potential therapy that in preclinical lab tests reversed an often-fatal childhood condition called Wolman disease.
AI detects a new class of mutations behind autism
30.05.2019
Many mutations in DNA that contribute to disease are not in actual genes but instead lie in the 99% of the genome once considered "junk." Even though scientists have recently come to understand that these vast stretches of DNA do in fact play critical roles, deciphering these effects on a wide scale has been impossible until now.
Interview with Hombrechtikon Systems Engineering AG
15.11.2018
Whether DNA testing, tissue analysis or blood tests – the secrets of life are unraveled in the laboratory. In order to master this challenge, all processes must first be optimized and automated. Which role HSE AG plays here, the Swiss company explains at MEDICA 2018.
On the trail of cancer: personalized cancer vaccine
01.03.2018
Conventional cancer treatment selection typically depends on the location of the tumor. However, this approach ignores the distinct gene mutations in the tumor of the individual patient. New cancer research approaches increasingly emphasize the concept of personalized therapy.
Personalized cancer medicine: customized treatment
01.03.2018
Everyone is different. This statement also applies to our health. Cancer, in particular, can look and progress differently depending on the individual person. That’s why every patient ideally also needs a customized treatment that is tailored to their individual needs. But how feasible is this idea?
Personalized medicine: a paradigm shift is gaining momentum
01.03.2018
Personalized medicine does not follow a "one-size-fits-all" treatment approach but emphasizes a "tailor-made" paradigm, meaning a treatment is customized to each individual person's case. For patients, this increases the chances of treatment success and means fewer side effects. While the approach originates in the field of oncology, it is now also increasingly applied to other disease patterns.
Prenatal diagnosis: genetic analysis using droplet PCR
24.07.2017
A new analysis method that uses fetal DNA extracted from the mother’s blood is designed to non-invasively reach a prenatal diagnosis of genetic disorders in a child. A task force of the Hahn Schickard Society for Applied Research is an active part of the "ANGELab" project and co-developed this diagnostic procedure.
Pneumonia in Children: Ultrasound or X-Rays?
08.03.2017
Pneumonia is the most frequent respiratory disease in children and can even cause death. That is why it is extremely important to make an accurate diagnosis as quickly as possible. If this requires imaging tests, normally X-rays are taken. But there is an alternative: ultrasound.
Collect Data? Utilize Data! – The Blessings of Big Data
01.03.2017
Genome data, MRI images, and blood test results – data collected in the medical sector is not only very heterogeneous but also extremely extensive. However, it is important to not only collect this data but to also utilize it. After all, processed, linked and analyzed data provides many opportunities in research, hospital management and ultimately also for the individual patient.
Gene therapy for the treatment of achromatopsia
01.02.2017
Achromatopsia is a rare hereditary visual disorder. Along with total color blindness, patients most notably suffer from reduced visual acuity and increased sensitivity to light and glare.