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Cells: potential liver cancer treatment
10.10.2019
Liver cancer is the second leading cause of cancer-related deaths worldwide. The most common primary liver cancer in adults is known as hepatocellular carcinoma (HCC), and accounts for approximately 780.000 deaths every year. Even with advanced surgical treatments or transplantation, the 5-year survival rate for HCC patients remains poor due to frequent recurrence.
Pathogens: new insights in tuberculosis
10.10.2019
Researchers at the University of Würzburg and the Spanish Cancer Research Centre have gained new insights into the pathogen that causes tuberculosis. The work published in Nature provides the basis for a new approach in antibiotic therapy.
Blood vessels: overly permeable
09.10.2019
In Germany alone there are around 400,000 patients who suffer from chronic inflammatory bowel diseases. For the first time, researchers have discovered that dysfunctions in blood vessels play a significant role in the development of such diseases. In experimental model systems, the progression of the disease slowed down significantly by eliminating these dysfunctions.
Pathogens: a mechanism to control autoimmunity
08.10.2019
The immune system relies on B cells and their ability to make antibodies against an extremely broad range of pathogens. This broad responsiveness bears some risk, as B cells can also turn against healthy tissue - a phenomenon called autoimmunity.
Immunotherapy: a promising antibody
07.10.2019
Acute lymphoblastic leukaemia (ALL) is the most common cancer in children. This form of blood cancer is caused by malignant abnormal precursor cells of certain white blood cells, and usually leads to a rapidly progressive reduction of bone marrow function, and thus impaired blood formation.
Cells: mechanism for the formation of new blood vessels
24.09.2019
Researchers from Uppsala University have revealed for the first time a mechanism for how new blood vessels are formed and have shown the importance of this mechanism for embryo survival and organ function. The results could be developed to control the formation of new blood vessels in different diseases. The new study is published in the journal EMBO Reports.
DNA: held together by hydrophobic forces
23.09.2019
Researchers at Chalmers University of Technology, Sweden, disprove the prevailing theory of how DNA binds itself. It is not, as is generally believed, hydrogen bonds which bind together the two sides of the DNA structure. Instead, water is the key. The discovery opens doors for new understanding in research in medicine and life sciences. The researchers' findings are presented in the journal PNAS.
Tissue engineering: Form is function
12.09.2019
Liquid-like tissue behavior is a key principle for the formation of structures in biological systems. Researchers at the Max Planck Institute of Colloids and Interfaces in Potsdam have shown that growing bone tissue behaves like a viscous liquid on long time scales, thereby accepting forms with minimal surface area.
DNA: construction kit replaces expensive antibody medication
11.09.2019
Researchers at KU Leuven in Belgium have developed a technique to make sheep produce new antibodies simply by injecting the DNA building blocks. This approach is much cheaper and more efficient than producing antibodies industrially and administering them afterwards. The study in animals with a similar size as humans brings us a step closer to the clinical use of antibody gene therapy.
Stem cells: antihistamines can kill leukaemic stem cells
09.09.2019
The IJC Leukaemic Stem Cell research group, led by Ruth M. Risueño, has discovered in preclinical trials that a particular group of antihistamines can kill leukaemic stem cells. This group investigates Acute Myeloid Leukaemia (AML) and the cell population responsible for the disease spreading, persisting, and if it has been treated and overcome, reappear.
Islet-on-a-chip: miniature device for diabetes research
30.08.2019
In a study led by Harvard University's Kevin Kit Parker, microfluidics and human, insulin-producing beta cells have been integrated in an "Islet-on-a-Chip". The new device makes it easier for scientists to screen insulin-producing cells before transplanting them into a patient, test insulin-stimulating compounds, and study the fundamental biology of diabetes.
Tissue Engeneering: bioprinting complex living tissue
26.08.2019
Tissue engineers create artificial organs and tissues that can be used to develop and test new drugs, repair damaged tissue and even replace entire organs in the human body. However, current fabrication methods limit their ability to produce free-form shapes and achieve high cell viability.
Precision medicine: graphene nanoflakes as a new tool
20.08.2019
Chemists funded by the SNSF have created a new compound for flexible drug delivery that specifically targets prostate cancer cells. Incorporating four different molecules, the compound prevents tumour cells from multiplying, can be detected by medical imaging and has staying power in the bloodstream.
Nanotechnology: better stem cell transplantation research
15.08.2019
Nanotechnology developed at Rutgers University-New Brunswick could boost research on stem cell transplantation, which may help people with Alzheimer's disease, Parkinson's disease, other neurodegenerative diseases and central nervous system injuries.
Regenerative medicine: 'Bone in a dish'
07.08.2019
Like real bone, the material developed at Oregon Health & Science University has a 3D mineral structure populated with living cells, providing a unique model to study bone function, diseases, regeneration.
Organ-on-a-chip systems: limited validity?
01.02.2019
Organ-on-a-chip systems are technically a great enhancement of medical research because they facilitate testing of active ingredients on cell cultures in the chambers of a plastic chip. This replaces animal testing and improves patient safety. That being said, they are not a true-to-life replication of the human body and can only simulate a few functions and activities.