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Antibiotic resistance: technical tricks against pathogens
01.08.2019
An untreatable infection is a nightmare for physicians and potentially life-threatening to the patient. Unfortunately, more and more pathogens emerge that are resistant to drugs, especially antibiotics. We need to use our drugs smartly and come up with technical solutions as well to prevent our weapons from blunting in the future.
Last-resort antibiotics: "We can identify carbapenemases within half an hour"
01.08.2019
Antibiotic resistance is modern medicine's greatest challenge. Some bacteria only respond to a handful of antibiotics, prompting hospitals to spend a lot of time finding an effective drug. That’s why it is critical for physicians to rapidly identify antibiotic resistance to avoid ineffective treatments.
Photonics: "We want a rapid and easy method to identify pathogens and antibiotic resistance"
01.08.2019
The medical devices value chain has gaps between academic research and industrial practice that slow down innovation processes. This also applies to time-sensitive and urgently needed products such as rapid diagnostic tests to identify resistant pathogens. At the InfectoGnostics Research Campus in Jena, partners from research and medicine team up to close these gaps.
Combating antibiotic resistance: One step ahead through technology
01.08.2019
Antibiotic resistance is on the rise in all parts of the world, complicating medical treatment of serious bacterial infections in patients. The World Health Organization estimates that approximately 33,000 people die each year from antibiotic-resistant bacteria in Europe alone. Bacteria that are resistant to multiple or even all known antibiotics pose an ever-increasing threat.
Antibiotic stewardship prevents overuse
19.07.2019
Antibiotic stewardship interventions for acute respiratory infection (ARI) is feasible and effective and can significantly reduce overuse in the emergency department (ED) and urgent care center (UCC) settings. That is the conclusion of a study to be published in Academic Emergency Medicine (AEM), a journal of the Society for Academic Emergency Medicine (SAEM).
AI: molecular tumor classification and prognosis in patients with colorectal cancer
09.07.2019
Treating physicians need information about the molecular subtype of the tumor if they are to provide targeted therapy for colorectal carcinoma. A research team from University Hospital Zurich and the University of Oxford have now developed a method to predict the molecular classification of colorectal cancer from digital pathology slides.
Human-on-a-chip: prediction of in vivo results based on in vitro model
08.07.2019
Hesperos Inc., pioneers of the human-on-a-chip in vitro system has announced the use of its innovative multi-organ model to successfully measure the concentration and metabolism of two known cardiotoxic small molecules over time, to accurately describe the drug behavior and toxic effects in vivo. The findings support the potential of body-on-a-chip systems to transform the drug discovery process.
Implants: remote-controlled drug delivery system for chronic disease management
26.06.2019
People with chronic diseases like arthritis, diabetes and heart disease may one day forego the daily regimen of pills and, instead, receive a scheduled dosage of medication through a grape-sized implant that is remotely controlled.
Blood-brain barrier chip: using stem cells for the first time
18.06.2019
Researchers at Ben-Gurion University of the Negev (BGU) and Cedars-Sinai Medical Center in Los Angeles have, for the first time, duplicated a patient's blood-brain barrier (BBB), creating a human BBB chip with stem cells, which can be used to develop personalized medicine and new techniques to research brain disorders.
Blood-Brain Barrier Chip: in vivo-like drug and antibody transport
17.06.2019
Like airport security barriers that either clear authorized travelers or block unauthorized travelers and their luggage from accessing central operation areas, the blood-brain-barrier (BBB) tightly controls the transport of essential nutrients and energy metabolites into the brain and staves off unwanted substances circulating in the blood stream.
Diagnostics: biomarkers help tailor diuretic use in acute heart failure patients
31.05.2019
Adrenomedullin activity predicts which acute heart failure patients are at the greatest risk of death without diuretic treatment post-discharge, according to late breaking research presented today at Heart Failure 2019, a scientific congress of the European Society of Cardiology (ESC).
React early, breathe free – comprehensive COPD management
01.03.2019
COPD is considered the third most common cause of death worldwide and mainly affects smokers. It is not curable, but with the right combination of early diagnosis, therapy and self-management, a significant part of the quality of life can be regained. The comprehensive care is supported by various devices and technical tools. Learn more about the all-round care of COPD in our Topic of the Month.
All-round care for COPD: diagnosis, treatment, self-management
01.03.2019
COPD affects more than 200 million people in the world. Those affected by this chronic pulmonary disease are often slow to notice the symptoms and get a medical diagnosis. This results in secondary complications and high medical costs. That's why an early diagnosis, comprehensive treatment, and frequent monitoring are very important. Various devices and tools support this all-round care.
Gentle medication for the little ones – with every breath
22.02.2019
According to the WHO, ten percent of babies worldwide are born prematurely. Since most organs of these tiny babies have not fully developed yet, it can quickly lead to complications and disorders and most notably affect the lungs of the premature infants. What's more, infections require gentle treatment, as the preemies themselves are fragile and susceptible – making this a challenging situation.
Hybrid Imaging – Two Views of the Lungs
25.01.2019
CT scan, MRI or X-ray: All these methods allow doctors to see inside the body - including inside the lungs - and make a diagnosis. The clinic for Nuclear Medicine at the RWTH Aachen University Hospital uses a state-of-the-art gamma camera that combines SPECT and CT.
The cure is in the capsule: carbon monoxide to treat chronic inflammation
22.05.2018
This unusual ally can be extremely valuable in the fight against inflammation in the body: CO (carbon monoxide). As a therapeutic gas, it also promises relief for inflammatory gastrointestinal diseases. Having said that, it is difficult to transport the active ingredient to the exact desired location.
Cells in space – extraterrestrial approaches in cancer research
22.02.2018
Here on Earth, all experiments are bound by gravitation. Yet, freed from gravity's grip, tumor cells, for example, behave in an entirely different way. As part of the "Thyroid Cancer Cells in Space" project by the University of Magdeburg, smartphone-sized containers carrying poorly differentiated thyroid cancer cells are sent into space.
Without any delay: drug dose adjustment at the point of care
01.08.2017
Many therapeutic drugs are very powerful, but they are also very toxic at the same time. Thus, they have to be measured regularly, again and again, so that an adjustment of the individual drug dosage can be made. Until now, the "normal" way was to take the blood sample, send it to a central laboratory and get the results after some days. A new point-of-care test can measure it in 15 minutes.
Swallowing Disorders – avoiding errors related to medication administration
27.01.2017
Dysphagia creates a stressful situation for patients. Added to this is the fact that acute errors in the treatment of swallowing disorders keep occurring when patients are administered drugs. How can patients with swallowing difficulties receive better care? We visited the Hüttenhospital Dortmund and asked Dr. Martin Jäger, an expert in this particular field.