Immune cells damage the integrity of the blood-brain barrier -- MEDICA - World Forum for Medicine

Immune cells damage the integrity of the blood-brain barrier

02.03.2020

Image: Microglia express tight junction molecule; Copyright: Hiroaki Wake

Microglia express tight junction molecule (CLDN5) to maintain BBB integrity in early phase and molecule for phagocytosis (CD68) to impair the BBB function in late phase of systemic inflammation. Microglia phagocytose astrocyte end feet which is one of the components of BBB.

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