Interviews 2019 -- MEDICA - World Forum for Medicine

Image: heart-EKG; Copyright: PantherMedia / BrianAJackson

Dynamic heart model advances engineered heart tissue technology

22/07/2021

Efforts to understand cardiac disease progression and develop therapeutic tissues that can repair the human heart are just a few areas of focus for the Feinberg research group. The group's latest dynamic model, mimics physiologic loads on engineering heart muscle tissues, yielding an unprecedented view of how genetics and mechanical forces contribute to heart muscle function.
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Image: a physician with a blood sample; Copyright: PantherMedia / microgen

'Shape memory' supports tissue growth

06/07/2021

A research has demonstrated the viability of 3D-printed tissue scaffolds that harmlessly degrade while promoting tissue regeneration following implantation. The scaffolds showed highly promising tissue-healing performance, including the ability to support cell migration, the 'ingrowth' of tissues, and revascularisation (blood vessel growth).
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Image: Nuclei of a human pancreatic organoid; Copyright: Carla A. Gonçalves / DanStem

New miniature organ to understand human pancreas development

25/05/2021

The pancreas is a little organ behind the stomach and has two main functions – digestion and blood sugar regulation. How the human pancreas develops has been relatively unexplored for ethical and practical reasons.
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Image: A self-organizing cardioid; Copyright: Mendjan/IMBA

Cardioids – Heartbeat, heartbreak and recovery in a dish

24/05/2021

Self-organizing heart organoids developed at IMBA – Institute of Molecular Biotechnology of the Austrian Academy of Sciences – are also effective injury- and in vitro congenital disease models. These “cardioids” may revolutionize research into cardiovascular disorders and malformations of the heart. The results are published in the journal Cell.
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Image: 3-D printed scaffold of a nose; Copyright: WSU

Researchers advance 3D printing to aid tissue replacement

07/05/2021

Professor Arda Gozen looks to a future someday in which doctors can hit a button to print out a scaffold on their 3-D printers and create custom-made replacement skin, cartilage, or other tissue for their patients.
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Image: cell matrix; Copyright: TU Wien

Multi-photon lithography: printing cells with micrometer accuracy

01/12/2020

How do cells react to certain drugs? And how exactly is new tissue created? This can be analyzed by using bioprinting to embed cells in fine frameworks. However, current methods are often imprecise or too slow to process cells before they are damaged. At the TU Vienna, a high-resolution bioprinting process has now been developed using a new bio-ink.
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Image: three vials, one with hydrogels, one with bio ink and one with unmodified gelatine; Copyright: Fraunhofer IGB

"Cells are highly sensitive" – material development for bioprinting

01/12/2020

The big hope of bioprinting is to someday be able to print whole human organs. So far, the process has been limited to testing platforms such as organs-on-a-chip. That's because the actual printing process already poses challenges. Scientists need suitable printing materials that ensure the cell's survival as it undergoes the procedure. The Fraunhofer IGB is researching and analyzing this aspect.
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Image: 3D printer with a human heart inside, next to a box with

Bioprinting: life from the printer

01/12/2020

It aims at the production of test systems for drug research and gives patients on the waiting lists for donor organs hope: bioprinting. Thereby biologically functional tissues are printed. But how does that actually work? What are the different bioprinting methods? And can entire organs be printed with it? These and other questions are examined in our Topic of the Month.
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Image: Man with mouthguard and laboratory glasses holding Petri dish up; Copyright: panthermedia.net/kasto

Cardiac Tissue Engineering: a heart out of the Petri dish

23/09/2019

For patients waiting for donor organs, every day can mean the difference between life and death. Making things even more complicated is the fact that not every organ is a compatible match with the patient. It would mean enormous progress if we could grow organs from the patient's own cells in the lab. That's why patients with heart disease place big hope in tissue engineering.
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Image: View over the shoulders of two doctors at a screen showing a model of a heart; Copyright: panthermedia.net/Wavebreakmedia ltd

Regenerative heart valves: from simulation to replacement

23/07/2018

Every year, more than 250,000 patients worldwide receive heart valve implants. Children require repeated replacement surgery because their bodies are still growing, the prosthetic heart valves are not. Regenerative heart valves solve this problem. Until now, we have only been able to monitor how these living implants develop in the body after the fact. Computer models now make this predictable.
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Image: Two hands are holding a tubular frame that is carrying a glistening wet, white tube; Copyright: Leibniz University of Hanover/Institute of Technical Chemistry

Tissue engineering: how to grow a bypass

23/04/2018

A bypass is a complicated structure. It is either made of synthetic materials that can cause blood clots and infections or created by using the patient’s veins. However, the latter often does not yield adequate material. A newly developed bioreactor could solve this problem in the future. It is designed to tissue engineer vascular grafts by using the body’s own material.
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"Spray-On" muscle fibers for biomimetic surfaces

08/01/2018

Few patients with heart failure are fortunate enough to receive a donor's heart. Ventricular assist devices (or heart pumps) have been around for several years and are designed to buy time as patients wait for a transplant. Unfortunately, the body doesn't always tolerate these devices.
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