Background Reports 2019 -- MEDICA - World Forum for Medicine

Image: A hand with a glove is holing a petri dish with bacterial cultures in it; Copyright: panthermedia.net/Lyoshanazarenko

Genetics: one quarter of bacteria can spread antibiotic resistance to peers

07.02.2020

Biomedical engineers at Duke University have demonstrated that at least 25 percent of antibiotic-resistant pathogenic bacteria found in clinical settings are capable of spreading their resistance directly to other bacteria.
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Image: A man in an MRI with his head fixed, next to him two physicians who discuss the images; Copyright: panthermedia.net/Ancikainfot

Advanced imaging and genomic analysis could help treat brain cancer

04.02.2020

Melding the genetic and cellular analysis of tumors with how they appear in medical images could give physicians and other cancer therapy specialists new insights into how to best treat patients, especially those with brain cancer, according to a new study led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope.
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Image: 2D and 3D fluidic networks by modularized stereolithography; Copyright: SUTD

3D printing of finer, more complex microfluidic networks

31.01.2020

First introduced in the 1980s, stereolithography (SL) is an additive manufacturing process that prints 3D objects by the selective curing of liquid polymer resin using an ultra-violet (UV) light source in a layer-by-layer fashion. The polymer employed undergoes a photochemical reaction which turns it from liquid to solid when exposed to UV illumination.
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Image: Organoids grown in the laboratory on some kind of bottles; Copyright: AlessioCoser for University of Trento

Organoids to study pediatric brain tumors

30.01.2020

Researchers are at work to find effective treatments to help young patients with brain tumors. Hundreds of brain organoids have been developed in the laboratories of the University of Trento to understand the genetic mechanisms responsible for these hard to treat diseases.
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Image: blood samples; Copyright: panthermedia.net/Kiyoshi Takahase Segundo

AI-analyzed blood test for neurodegenerative disease

29.01.2020

Evaluating the effectiveness of therapies for neurodegenerative diseases is often difficult because each patient's progression is different. A new study shows artificial intelligence (AI) analysis of blood samples can predict and explain disease progression, which could one day help doctors choose more appropriate and effective treatments for patients.
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Image: A smartphone is held above a petri dish with test strips; Copyright: University of Bath

Smartphone cameras can speed up urinary tract infection diagnosis

13.01.2020

Biological Engineers at the University of Bath have developed a test that could help medics quickly diagnose urinary tract infections (UTIs), using a normal smartphone camera.
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Image: professor shows the microfluidic chip to the camera; Copyright: The University of Texas at Dallas

Lab-on-a-chip: fabricated corneal tissue shows how eyes heal

10.01.2020

Cells called corneal keratocytes are innately programmed to come to the rescue if the eye is injured. This natural healing process sometimes fails, however, resulting in scarring and blindness. Scientists are still trying to understand why.
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Image: binary code on black ground; COLOURBOX.de

Artificial Intelligence tracks down leukemia

09.01.2020

Artificial intelligence can detect one of the most common forms of blood cancer – acute myeloid leukemia (AML) – with high reliability. Researchers at the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn have now shown this in a proof-of-concept study. Their approach is based on the analysis of the gene activity of cells found in the blood.
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Image: Robot points with his finger at CT images of the brain, in the background a CT device; Copyright: panthermedia.net/phonlamai

Smart algorithm finds possible treatment for childhood cancer

09.01.2020

Using a computer algorithm, scientists at Uppsala University have identified a promising new treatment for neuroblastoma. This form of cancer in children, which occurs in specialised nerve cells in the sympathetic nervous system, may be life-threatening.
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Image: man at a microscope; Copyright: DEAN ISHIDA

Biomarker predicts risks in patients with heart failure

07.01.2020

A UCLA-led study revealed a new way to predict which patients with "stable" heart failure – those who have heart injury but do not require hospitalization – have a higher risk of dying within one to three years.
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Image: close-up of tissue; Copyright: panthermedia.net/drlange

Tissue Engineering: tracking lab-grown tissue with light

16.12.2019

New proof-of-concept photonic pH sensor could advance studies of tissue regeneration. Someday, doctors would like to grow limbs and other body tissue for soldiers who have lost arms in battle, children who need a new heart or liver, and many other people with critical needs.
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Image: scanning electron microscope image of NETs; Copyright: Urban, et al., Max Planck Institute

Machine learning: to measure inflammation process

13.12.2019

UNC School of Medicine researchers created an artificial intelligence tool to measure NETosis, an inflammatory process where white blood cells trap invaders; this work will help scientists find ways to stop or promote NETosis in disease states
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Image: diagnostic test on a table; Copyright: beta web GmbH/Melanie Prüser

Single-use tests: sensitivity and easy use combined for diagnostics

12.12.2019

Diagnostic testing usually takes some time and a sterile environment to get the results. To cut down on the costs and effort spend on these tasks there are different diagnostic tests. One of them are single-use tests offered by SensDx S.A. The technology behind them not only makes the process faster and easier, but provides the opportunity to expand into home use in the future as well.
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Image: laboratory technology; Copyright: panthermedia.net/Robert Przybysz

Analyser system: Epigenomic technology combats disease

11.12.2019

Much remains unknown about diseases and the way our bodies respond to them, in part because the human genome is the complete DNA assembly that makes each person unique. A Virginia Tech professor and his team of researchers have created new technology to help in understanding how the human body battles diseases.
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 Image: illustration of the ConvPath software workflow; Copyright: UTSW

Software tool: AI helps doctors identify cancer cells

11.12.2019

UT Southwestern researchers have developed a software tool that uses artificial intelligence to recognize cancer cells from digital pathology images - giving clinicians a powerful way of predicting patient outcomes.
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Image: sci-Plex technique; Copyright: panthermedia.net/Wavebreakmedia (YAYMicro)

Drug information system: shows how cancer cells react to drugs

10.12.2019

A new technique overcomes several limitations of typical high-throughput chemical screens conducted on cell samples. Such screens are commonly used to try to discover new cancer drugs, and in many other biomedical applications.
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Image: A physician is holding a plastic cup for urine samples; Copyright: panthermedia.net/terovesalainen

Diagnostics: New home urine test for prostate cancer

02.12.2019

A simple urine test under development for prostate cancer detection can now use urine samples collected at home - according to new research from University of East Anglia and the Norfolk and Norwich University Hospital.
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Image: Diascopic's iON platform next to a laptop; Diascopic, LLC

AI: startup developing tool for tuberculosis detection

27.11.2019

Diascopic LLC, a Cleveland-based medical research company that develops diagnostic technology, will use a highly competitive federal grant to develop and apply new artificial intelligence (AI) and digital pathology tools for detecting tuberculosis (TB).
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Image: Blood sample labelled

Cardiac diagnostics – prompt and personalized

08.11.2019

If physicians suspect an acute myocardial infarction, they first order an ECG. This test is very established and allows cardiologists to quickly diagnose acute heart attacks – though the test does not detect less common heart attack symptoms. So far, those patients had to wait up to twelve hours before a heart attack could be accurately diagnosed or ruled out. But things are about the change.
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Image: A little toy figure of a man in a suit is standing on a print-out of DNA sequencing; Copyright: panthermedia.net/filmfoto

MEDICA LABMED FORUM: full speed ahead for careers in laboratory medicine

04.11.2019

Laboratories are medicine’s secret weapon because they handle the lion’s share of diagnostics often without patients even realizing it. That’s why the continuing workforce shortage in both laboratory medicine and companies is especially troubling. The MEDICA LABMED FORUM 2019 plans to address and counteract this development.
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Image: Flags are blowing in the wind to the backdrop of a dark evening sky; Copyright: Messe Düsseldorf/ctillmann

Medicine at the pulse of time: Innovations and trends at MEDICA 2019

04.11.2019

Soon, the world's largest trade fair for medical technology will open its doors again: More than 5.000 exhibitors will present their newest products and ideas at MEDICA from 18 to 21 November. You will not only meet well-known companies here, but also lots of young start-ups. Or, you can visit the MEDICA forums and conferences to experience a rich program of lectures and discussions.
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Image: Volker Bruns; Copyright: Fraunhofer ISS

AI software: "iSTIX opens your world to the possibilities of digital pathology"

08.10.2019

The healthcare market offers a multitude of microscopes that make cells visible to the human eye. The same applies to AI-based software for image analysis. After taking the microscopic images, scientist are faced with large volumes of scans with usually low resolution. Yet when all aspects merge together, they open up a the world of digital pathology.
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Image: MEDICA START-UP PARK; Copyright: Messe Düsseldorf/ctillmann

MEDICA START-UP PARK: "For those, who want to experience the startup-spirit"

01.10.2019

When the halls of MEDICA are open to the world to showcase medical innovations, one joint exhibition booth is guaranteed to attract special attention - the MEDICA START-UP PARK. The startups that present their advances in this setting are interesting to visitors and investors, yet long-time exhibitors and big businesses can also benefit from building relationships with these young companies.
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Image: Man with mouthguard and laboratory glasses holding Petri dish up; Copyright: panthermedia.net/kasto

Cardiac Tissue Engineering: a heart out of the Petri dish

23.09.2019

For patients waiting for donor organs, every day can mean the difference between life and death. Making things even more complicated is the fact that not every organ is a compatible match with the patient. It would mean enormous progress if we could grow organs from the patient's own cells in the lab. That's why patients with heart disease place big hope in tissue engineering.
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Image: Participants of the German Medical Award 2018; Copyright: German Medical Award

German Medical Award 2019 celebrates the future of (patient) care

22.08.2019

The German Medical Award will take place on November 18, 2019, as part of the MEDICA trade fair in Düsseldorf. The ceremony emphasizes the commitment to excellence in cutting-edge care for patients. Doctors, clinical centers and companies in the medical and healthcare industry can demonstrate their achievements in medicine and management in hopes of receiving the coveted award.
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Image: Laboratory situation - Prof. Popp shows a young man a small object in his hand; Copyright: Leibniz-IPHT/Sven Döring

Tumor excision: triple imaging for unique diagnostics

08.08.2019

After their tumor has been removed, some patients have to return to the hospital to undergo surgery again. That's because the tumor was not precisely identified and was subsequently not completely removed. That's both an ethical and financial dilemma. A new surgery-adjacent procedure is designed to rapidly and accurately detect tumors.
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Image: A lab technician is using a pipette to fill a solution into a petri dish; Copyright: panthermedia.net/Arne Trautmann

Last-resort antibiotics: "We can identify carbapenemases within half an hour"

01.08.2019

Antibiotic resistance is modern medicine's greatest challenge. Some bacteria only respond to a handful of antibiotics, prompting hospitals to spend a lot of time finding an effective drug. That’s why it is critical for physicians to rapidly identify antibiotic resistance to avoid ineffective treatments.
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Image: Two petri dishes with different kinds of agar plates on which bacterial cultures are growing; Copyright: panthermedia.net/photographee.eu

Antibiotic resistance: technical tricks against pathogens

01.08.2019

An untreatable infection is a nightmare for physicians and potentially life-threatening to the patient. Unfortunately, more and more pathogens emerge that are resistant to drugs, especially antibiotics. We need to use our drugs smartly and come up with technical solutions as well to prevent our weapons from blunting in the future.
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Image: Flags; Copyright: SilverSky LifeSciences GmbH

Striking new paths in medicine - Diagnostics Partnering Conference 2019

08.07.2019

On November 18th, 2019, parallel to the first day of MEDICA, the world forum for medicine, the Diagnostics Partnering Conference (DxPx Conference) will take place in Düsseldorf, bringing together stakeholders in the diagnostics and research tool industry. The DxPx Conference focuses on discovering technologies, finding financing and investment opportunities and forming collaborative partnerships.
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Image: Cell cultivation in a Petri dish; Copyright: panthermedia.net / matej kastelic

Organ-on-a-chip – Organs in miniature format

01.02.2019

In vitro processes and animal tests are used to develop new medications and novel therapeutic approaches. However, animal testing raises important ethical concerns. Organ-on-a-chip models promise to be a feasible alternative. In a system the size of a smartphone, organs are connected using artificial circulation.
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Image: Man and woman in a laboratory presenting a multi-organ chip; Copyright: TissUse GmbH

Multi-Organ Chips – The Patients of Tomorrow?

01.02.2019

The liver, nervous tissue or the intestines: all are important human organs that have in the past been tested for their function and compatibility using animal or in vitro test methods. In recent years, TissUse GmbH, a spin-off of the Technical University of Berlin (TU Berlin), has launched multi-organ chip platforms. But that’s not all.
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Image: Graphic rendering of several cells in a petri dish; Copyright: panthermedia.net/dani3315

Organ-on-a-chip systems: limited validity?

01.02.2019

Organ-on-a-chip systems are technically a great enhancement of medical research because they facilitate testing of active ingredients on cell cultures in the chambers of a plastic chip. This replaces animal testing and improves patient safety. That being said, they are not a true-to-life replication of the human body and can only simulate a few functions and activities.
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From algorithm to rapid test – Artificial Intelligence classifies blood cells

21.11.2018

Our blood reveals a lot about our physical health. The shape of our blood cells sheds light on several hereditary diseases for example. For a diagnosis, the cells must first be examined under the microscope and categorized into a specific cell class. We met with Dr. Stephan Quint and Alexander Kihm of the Institute of Physics at the Saarland University, who explained how this classification works.
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Image: Preview picture to the video

Interview with Hombrechtikon Systems Engineering AG

15.11.2018

Whether DNA testing, tissue analysis or blood tests – the secrets of life are unraveled in the laboratory. In order to master this challenge, all processes must first be optimized and automated. Which role HSE AG plays here, the Swiss company explains at MEDICA 2018.
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Image: Preview picture to the video

Interview with ERBA Diagnostics Mannheim GmbH

15.11.2018

A lot of answers in medicine are found in the laboratory. Correct analysis is key to find the right diagnosis and cure for the patient. We learn more about innovative analysis devices at the stand of ERBA Diagnostics at MEDICA 2018.
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Image: several leg pairs during a run; Copyright: panthermedia.net/lzf

Diagnostics at record speeds – POCT in high-performance sports

02.11.2018

This is what diagnostic investigation normally looks like: a patient sample is collected, sent to the laboratory and analyzed. Once that's completed, the patient is told of the lab test result. But if the patient is a high-performance athlete and has to follow and stick to a rigid training schedule, he or she needs these results immediately. What makes this possible? Point-of-care testing!
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Image: About eight in ten Germans suffer from back pain during their lifetime; Copyright: panthermedia.net/stasique

Back pain: The research project Ran Rücken is intended to help

10.09.2018

About eight in ten Germans suffer from back pain during their lifetime. Too much or the wrong movements can also cause problems. "Ran Rücken", the interdisciplinary research project aims to determine the right minimum dose of exercise that proves effective. (Explanatory note: "Ran Rücken" can be loosely translated as "Target the Back")
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Image: Maria Driesel and her colleagues from inveox next to the new device; Copyright: Astrid Eckert

Pathology 4.0 – inveox automates laboratory processes

22.08.2018

Mix-ups, contamination and sample loss – most errors in pathology happen when specimen are received. Countless samples arrive daily at the laboratory, while the sample entry process is very monotonous. As a result, the work is inefficient. The start-up company inveox has now developed a system that automates the processes in the pathology laboratory, thus making them more efficient.
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Personalized cancer medicine – Best possible treatment with TherapySelect

30.04.2018

Medicine is getting more and more personalized. This is particularly interesting for oncology, since a cancer is as individual as the respective patient. When choosing a therapy, both the characteristics of the tumor and the personal characteristics of the patient must be considered. To see exactly what this looks like, we visited the diagnostics company TherapySelect, based in Heidelberg.
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Image: Three men in suits and a woman in a laboratory coat are standing in a laboratory; Copyright: Ministry of Economy of Mecklenburg-Hither Pomerania/Norbert Fellechner

On the trail of cancer: personalized cancer vaccine

01.03.2018

Conventional cancer treatment selection typically depends on the location of the tumor. However, this approach ignores the distinct gene mutations in the tumor of the individual patient. New cancer research approaches increasingly emphasize the concept of personalized therapy.
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Image: yellow tape measure with capsules in front of it; Copyright: panthermedia.net/Jiri Hera

Personalized cancer medicine: customized treatment

01.03.2018

Everyone is different. This statement also applies to our health. Cancer, in particular, can look and progress differently depending on the individual person. That’s why every patient ideally also needs a customized treatment that is tailored to their individual needs. But how feasible is this idea?
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Image: a container with the nutrient medium for cancer cells; Copyright: Dr. Markus Wehland

Cells in space – extraterrestrial approaches in cancer research

22.02.2018

Here on Earth, all experiments are bound by gravitation. Yet, freed from gravity's grip, tumor cells, for example, behave in an entirely different way. As part of the "Thyroid Cancer Cells in Space" project by the University of Magdeburg, smartphone-sized containers carrying poorly differentiated thyroid cancer cells are sent into space.
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Image: Stethoscope lying on a world map and transparent icons placed over the entire image; Copyright: panthermedia.net/everythingposs

Everything flows: transportation and material flows in hospital logistics

01.02.2018

During a visit to the hospital, patients naturally expect to receive comprehensive care. Not only does this include the proper treatment, but also a hospital bed and regular meals for example. Patients typically don't ask about the transport logistics this entails for the hospital.
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"Spray-On" muscle fibers for biomimetic surfaces

08.01.2018

Few patients with heart failure are fortunate enough to receive a donor's heart. Ventricular assist devices (or heart pumps) have been around for several years and are designed to buy time as patients wait for a transplant. Unfortunately, the body doesn't always tolerate these devices.
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Image: Three-dimensional image of a colored vessel structure; Copyright: René Hägerling

Pathology: detecting lymphedema with 3D microscopy

23.10.2017

According to the WHO, 300 million people throughout the world are affected by lymphedema. This condition occurs when fluid that flows between cells is no longer transported back into the blood circulation and accumulates in the skin. Triggers can be surgeries, injuries or genetic defects for example. A new microscopy technique could now also indicate the causes.
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Image: Preview picture of video

Point-of-care testing in the hospital – quality diagnostic results

18.10.2017

Point-of-care testing is an integral part of medicine. It enables simple, automated testing that yields fast results. Hospitals have also started to increasingly use POCT diagnostic systems over the past few years. We are guests at the Greifswald University Hospital where patient-side rapid diagnostic tests have already been successfully integrated into daily hospital operations.
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Image: interferometric detection of scattered light, iSCAT; Copyright: MPL

Interface between Physics and Medicine: new interdisciplinary center

22.08.2017

Physics has always supported medical science, especially when it comes to practical implementation. Now physicists and health professionals join in collaborative research at an interdisciplinary Center in Erlangen and incorporate fundamental principles of theoretical physics in their studies of diseases.
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Image: A man is working at a laboratory bench, his screen is showing a program that recognizes his gestures; Copyright: Fraunhofer IPA/Heike Quosdorf

Laboratory automation: from note book to gesture recognition

08.08.2017

For centuries, scientific research has succeeded by chronicling experiments with pinpoint accuracy. Yet despite all the progress in the actual laboratory, recording is often still done manually, in notebooks, logs or computer systems for instance. In the future, a gesture recognition system could perform this task for scientists.
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Image: Collage made of two images, one show a round, transparent plastic disc with micro channels, one shows a plastic chip; Copyright: Hahn-Schickard, Image Bernd Müller

Prenatal diagnosis: genetic analysis using droplet PCR

24.07.2017

A new analysis method that uses fetal DNA extracted from the mother’s blood is designed to non-invasively reach a prenatal diagnosis of genetic disorders in a child. A task force of the Hahn Schickard Society for Applied Research is an active part of the "ANGELab" project and co-developed this diagnostic procedure.
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