19/09/2017To fight infections cells in the immune system play a dangerous game with their own genes. Damaging genes allows B cells to make antibodies that are specifically equipped to target to specific causes of illness, but damaging genes also puts them at risk of becoming cancerous.
19/09/2017Looking at cell metabolism instead of histology, EPFL scientists have identified new biomarkers that could help more accurately classify the two main subtypes of hepatoblastoma, a children liver cancer. Hepatoblastoma is a rare pediatric liver cancer, usually diagnosed in the first three years of life.
15/09/2017With participation of the Helmholtz Zentrum München, an international research team has discovered a number of new risk factors for dilated cardiomyopathy and other heart conditions. In the largest transcriptome study to date, the researchers analysed the RNA of transplanted hearts. The study was recently published in "Genome Biology".
15/09/2017The coralberry could offer new hope for asthmatics: researchers at the University of Bonn have extracted a new kind of active pharmaceutical ingredient from its leaves to combat this widespread respiratory disease.
14/09/2017In a new study from Lund University in Sweden, researchers investigated the risk factors for blood clots, i.e. venous thromboembolism (VTE). The results show a strong correlation between height and VTE risk for both women and men. The risk increases with height.
14/09/2017Research may inform how increased glucose metabolism may contribute to the increased risk of thrombosis in diabetes and how altering platelet glucose metabolism influences platelet function
13/09/2017Liver cancer is the second-leading cause of cancer-related death and represents the fastest rising cancer worldwide. In most cases, the tumor develops in patients with chronic liver disease. Such diseases include chronic infections with hepatitis viruses or a so-called fatty liver due to nutritional or genetically caused lipometabolic disorders or an excessive consumption of alcohol.
13/09/2017By combining new system-biological analyses and advanced data analysis, researchers at Karolinska Institutet have been able to monitor the maturation process of the immune system of leukaemia patients who have undergone stem cell transplantation.
12/09/2017An herb widely used in traditional Chinese medicine might hold the key to a new osteoporosis therapy that could prevent bone loss without causing side effects.
11/09/2017IBS biologists discovered a key regulator of normal as well as pathological formation of new blood vessels.
11/09/2017Patients with head and neck squamous cell carcinoma who are positive for human papilloma virus (HPV-positive) have been observed to respond significantly better to chemo-radiotherapy than HPV-negative patients. This observation is surprising because HPV infection leads to an increased risk of developing oropharyngeal cancer. To date, the reason for this dichotomy has not been well understood.
08/09/2017Adenoviral infections have a mild disease progression in healthy people, but it can be dangerous for immunocompromised people. If a patient is infected with the virus and gets a bacterial infection on top of it, it can lead to an excessive inflammatory response known as a cytokine storm, an overreaction by the immune system leading to high concentrations of proteins that promote inflammation.
07/09/2017In a joint international study, researchers from Osaka University have partnered with research groups from the United States and Spain to uncover how mutations in a single gene called PKHD1 lead to symptoms associated with a rare kidney and liver disease, ARPKD (autosomal recessive polycystic kidney disease).
06/09/2017Ground breaking research could reduce the recurrence of prostate cancer in males, a new study in the journal Nature Communications reports.
06/09/2017Researchers at ETH Zurich, Empa and the Norwegian research institute SINTEF are pursuing a new approach to treating arthritis. This is based on a polysaccharide, a long-chain sugar molecule, originating from brown algae.
05/09/2017Researchers are moving closer to realizing the clinical potential of drugs that have previously been shown to support healthy aging in animals.
04/09/2017For the first time, a relationship has been found between foetal genes and the risk of preeclampsia in the mother. Norwegian researchers, including a team from the Norwegian University of Science and Technology (NTNU), figure prominently in the international group that presented the find in "Nature Genetics", first published online earlier this summer.
04/09/2017New research reveals the mechanisms behind the effects of chronic stress and tiny inflammations in the brain on fatal gut failure. Hokkaido University researchers revealed that fatal gut failure in a multiple sclerosis (MS) mouse model, EAE, under chronic stress is caused by a newly discovered nerve pathway.
01/09/2017Scientists at IRB Barcelona identify a key component of the machinery that allows Staphylococcus aureus to transfer genes that confer antibiotic resistance.
31/08/2017UT Southwestern Medical Center researchers report for the first time that tumors stressed by cancer immunotherapy release their mitochondrial DNA into nearby immune cells, triggering a host alert system.
30/08/2017Individuals with severe overweight have an inhibited sense of satiation - they release fewer satiety hormones than people of normal weight. The reason: the responsible cells in the gastrointestinal tract of obese people are severely reduced. This report Swiss doctors in the journal Scientific Reports. Surgical weight-loss procedures can repair this disorder.
29/08/2017Such detailed images of the pathogen that causes sleeping sickness inside a host are unique so far: They illustrate the manifold ways in which the parasites move inside a tsetse fly. A research team from the University of Würzburg's Biocenter has presented the images.
29/08/2017Omega-3 fatty acids, which we primarily get through eating fatty fish, have long been thought to be good for our health. Many dietary studies have suggested that high intake is associated with a reduced risk of various disorders. Clinical trials have also shown beneficial anti-inflammatory effects in patients taking omega-3 supplements.
28/08/2017Researchers at Aston University and clinicians at Birmingham Children's Hospital are exploring how children living with asthma can be supported to maintain a healthy weight.
25/08/2017According to the current doctrine, cancer cells develop due to mutations in genomic DNA. But could it be also caused also by faulty RNA molecules? A number of clues are pointing to this surprising hypothesis.
23/08/2017Researchers at the University of Basel have developed a test to quickly and reliably diagnose a rare and severe immune defect, hepatic veno-occlusive disease with immunodeficiency. They reported on their findings in the "Journal of Clinical Immunology".
23/08/2017There may be no silver bullet for treating liver cancer or fatty liver disease, but knowing the right targets will help science develop the most effective treatments. Researchers in Sweden have just identified a number of drug targets that can be used in the development of new efficient treatment strategies with minimum side effects.
22/08/2017Physics has always supported medical science, especially when it comes to practical implementation. Now physicists and health professionals join in collaborative research at an interdisciplinary Center in Erlangen and incorporate fundamental principles of theoretical physics in their studies of diseases.
22/08/2017In its attempt to fight a serious bacterial infection, caused by listeria, for example, the immune system can become so over-activated that the resulting inflammatory response and its consequences can quickly lead to death.
21/08/2017An Empa team has succeeded in developing a new three-dimensional cell model of the human placental barrier. The "model organ" can quickly and reliably deliver new information on the intake of substances, such as nano-particles, by the placental barrier and on any possible toxic effects for the unborn child.
16/08/2017Scientists from the University of Würzburg have synthesized a complex sugar molecule which specifically binds to the tumor protein Galectin-1. This could help to recognize tumors at an early stage and to combat them in a targeted manner
15/08/2017Antidepressant use is associated with an increased risk of head injuries and traumatic brain injuries among persons with Alzheimer's disease, according to a new study from the University of Eastern Finland. Antidepressant use has previously been linked with an increased risk of falls and hip fractures, but the risk of head injuries has not been studied before.
15/08/2017Researchers at Uppsala University have developed a new method for very rapidly determining whether infection-causing bacteria are resistant or susceptible to antibiotics. The findings have now been published in the US journal Proceedings of the National Academy of Sciences (PNAS).
14/08/2017Researchers at the University of Bergen have transformed skin puncture cells from diabetes patients into insulin producing cells, using stem cell techniques. The researchers' aim is to transplant these cells under the skin of people with diabetes.
08/08/2017Pulmonary fibrosis can possibly be attributed to a kind of cellular aging process, which is called senescence. This has been shown by researchers from the Helmholtz Zentrum München, partner in the German Center for Lung Research (DZL). As they report in the European Respiratory Journal, they have already successfully counteracted this mechanism in the cell culture with the help of drugs.
07/08/2017Researchers at the Stowers Institute for Medical Research have solved the three-dimensional structure of a complex that is essential for the correct sorting of chromosomes into eggs and sperm during reproductive cell division or meiosis.
04/08/2017A new study suggests that T cells, which help the body's immune system recognize friend from foe, may play an important role in Parkinson's disease (PD). The study, published in the journal Nature, was supported by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.
04/08/2017Freiburg neuroscientists develop new forms of diagnosis and therapy for temporal lobe epilepsy.
02/08/2017A molecule produced by insulating glial cells facilitates the functional wiring of brain cells involved in motor coordination.
01/08/2017Arteriogenesis is a critical event – not only during development but also in adult life. Cardiovascular life-threatening events could be overcome for example by inducing the formation of new arteries. A team of scientists led by Ralf Adams from the Max Planck Institute for Molecular Biomedicine has developed a genetic approach in mice to uncover molecular mechanisms of arterial growth.
01/08/2017Researchers have identified a new cell mechanism that could lead to a fundamental change in the diagnosis and treatment of leukaemia.
01/08/2017Many therapeutic drugs are very powerful, but they are also very toxic at the same time. Thus, they have to be measured regularly, again and again, so that an adjustment of the individual drug dosage can be made. Until now, the "normal" way was to take the blood sample, send it to a central laboratory and get the results after some days. A new point-of-care test can measure it in 15 minutes.
31/07/2017Hepatitis E gets little press compared to its better-known cousins A, B and C, but Stellenbosch University virologists say we should wake up to how transmission of this virus is changing.
20/07/2017Decades before people with Alzheimer's disease develop memory loss and confusion, their brains become dotted with plaques made of a sticky protein - called amyloid beta - that is thought to contribute to the disease and its progression.
19/07/2017Fanconi anemia is a rare genetic disease characterized by high cancer risk. Researchers of the University of Würzburg now have revealed a new Fanconi anemia gene that is involved in complex DNA repair processes and may also play a relevant role in cancer prevention.
19/07/2017Many animal species display flocking behaviour, but the fact that microorganisms do, is not as well known. Researchers at Lund University in Sweden have now shown that algae and bacteria form flocks at very low concentrations of individuals, a finding that could increase our future understanding of how the organisms infect their host animals.
18/07/2017Scientists investigating the genetic causes and altered functioning of nerve cells in motor neurone disease (MND) have discovered a new mechanism that could lead to fresh treatment approaches for one of the most common forms of the disease.
03/07/2017Photodynamic therapy is often used to treat brain tumors because of its specificity - it can target very small regions containing cancerous cells while sparing the normal cells around it from damage. It works by injecting a drug called a photosensitizer into the bloodstream, where it gathers in cells, and then exposing the drug-filled cells to light.
03/07/2017Precision work is absolutely essential in eye surgery since the surgical site is very minute and sensitive. This is why eye surgeons have been using lasers for years. Femtosecond lasers are especially well suited to serve this purpose because they are able to cut tissue with great precision and little energy, which prevents unwanted side effects of surgery.
26/06/2017Exosomes - tiny biological nanoparticles which transfer information between cells - offer significant potential in detecting and treating disease, the most comprehensive overview so far of research in the field has concluded.
22/06/2017Many bacteria are armed with nano-spearguns, which they use to combat unwelcome competitors or knockout host cells. The pathogen responsible for tularemia, a highly virulent infectious disease, uses this weapon to escape from its prison in cells defending the host. Researchers from the Biozentrum of the University of Basel report on this bacterial strategy.
08/12/2016Watching millions of neurons in the brain interacting with each other – for a long time this was possible only to a limited extent. The current techniques can visualize only superficial layers or the imaging they use is too slow. But now, Prof Daniel Razansky and his team have found a new method to visualize the brain activity – by using optoacoustics.
08/08/2016What happens when stem cells differentiate? What molecular characteristics do they have? Questions that can now be easier answered with the help of a new open-source software. We spoke with Prof. Fabian Theis at the Helmholtz Center Munich, who participated in the software development.
22/07/2016Millions of people all over the world suffer from partial blindness – caused by glaucoma, a stroke or traumatic brain injury. For years, the loss of vision was deemed irreversible. But now a new treatment makes it possible to improve eyesight and vision.
09/02/2016Many people suffer from atherosclerosis, especially in developed countries. The buildup of fatty deposits inside the arterial blood vessels leads to strokes and heart attacks. Now, a new method is designed to get to the root of the problem, and with the help of nanoparticles inject new turbo replacement cells into the blood vessels which are intended to exert their curative effect.
01/02/2016Self-healing powers like a superhero on the big screen? That’s the aim of regenerative medicine; at least in a very broad sense. This promising field of biomedicine is currently highly dynamic with innovative technologies and development. New methods are designed to help propel medicine into a whole new sphere.
01/02/2016Children, especially newborns, are generally no longer simply considered to be small adults whose treatment just needs to be "reduced". This is why a pediatrician’s education includes several specialties because ultimately everything in terms of care comes together here.
01/10/2015Semiconductor nanoparticles for biomedical applications have been researched for some time now. Not only are they millionths of a millimeter in size, they also offer great potential for cancer diagnostics and therapy, so-called theranostics. They enter cells, are activated by ultrasonic radiation and destroy the cells using the generated vibration.
02/03/2015Crises come in many shapes and sizes. Whether it’s poor hygiene, thefts or treatment errors – once the crisis has arrived, things need to move quickly. For hospitals in particular, the right crisis communication is key. Yet many medical facilities still neglect the fact that crisis communication starts before the actual crisis takes place.
02/02/2015The digitization of medicine moves on. Researchers, physicians and patients equally benefit from this development – thanks to improved diagnostics with highly sensitive devices, today findings can be comprehensively analyzed and treatment decisions made on a broadened basis. Digitization also offers the area of pathology interesting fields of application.
05/01/2015T-cells are the guardians of our immune system. When they show changes, it can lead to severe inflammatory responses in the body. It is believed that the T-cells in persons who are affected by inflammatory bowel disease don’t work properly. Two proteins that can be found on activated T-cells and that interact with each other are now being analyzed.
03/11/2014The treatment of chronic wounds is extremely problematic. Chronic wounds can take months or years to heal and some even never heal resulting in over 100.000 amputations taking place annually in the US alone. A new technology from Iceland, that is based on fish skin and is already used clinically, allows for improved healing of chronic and burn wounds.
03/11/2014As an imaging procedure, magnetic resonance tomography has become essential in clinical practice, since it can easily make organs and tissue visible. However, until now abnormal cancer cells or small centers of inflammation remained almost invisible. Now cell biologists from Berlin, Germany, have succeeded in fixing this problem with xenon magnetic resonance imaging.
01/10/2014On November 10, 2014, astronaut Alexander Gerst will return to Earth from the International Space Station (ISS). He is not just anxiously expected by his family, but also by Dr. Anna-Maria Liphardt from the Institute of Biomechanics and Orthopedics at the German Sport University Cologne
01/07/2014Large burns require skin grafting. Surgeons remove split-thickness skin grafts and apply them to the injured areas. Now skin that has been made in a laboratory is meant to help in covering burns as well as chronic wounds and thus promote the healing process. Researchers in Zurich have been working on this for more than 13 years.
01/07/2014In patients with Parkinson's, neural cells in the brain die off that produce the neurotransmitter dopamine. Certain physical symptoms that can indicate the disease follow years later. But a reliable diagnosis can only be made through examination of the brain after the patient's death, and not during his lifetime.
01/07/2014The not so popular “love handles“ could revolutionize medicine in the near future. In cooperation with the University of Rostock (Professor Hermann Seitz), the human med AG Company currently seeks to develop a device that is able to gently remove adipose tissue during surgery and subsequently isolate stem cells.
10/02/2014Prof. Joachim Heberle from the Free University of Berlin wants to make the smallest protein structures visible under the microscope. He wants to accomplish this with an infrared microscope, originating in the field of physics. He told MEDICA.de which technology is behind all this and what he also wants to examine with it in the future.
03/02/2014Differentiating tumor tissue from healthy tissue isn’t always easy for surgeons. Scattered cancer cells and early cancer are often hard to detect with the naked eye. A special camera now makes even the tiniest remainder of a tumor visible during surgery.
22/01/2014It guards the body but can become its enemy: the immune system defends us from intruding pathogens; it is also able to cause severe diseases if it falsely recognizes the body itself as a threat. Molecular receptors in the whole body enable the immune system to “sense” what happens within.