23/02/2018Scientists at The Scripps Research Institute (TSRI) have achieved a major milestone toward designing a safe and effective vaccine to both treat heroin addiction and block lethal overdose of the drug. Their research, published today in the journal Molecular Pharmaceutics, shows how a new anti-heroin formulation that is safe in animal models remains stable at room temperature for at least 30 days.
23/02/2018Each year, influenza kills half a million people globally with the elderly and very young most often the victims. In fact, the Centers for Disease Control and Prevention reported 37 children have died in the United States during the current flu season.
22/02/2018Here on Earth, all experiments are bound by gravitation. Yet, freed from gravity's grip, tumor cells, for example, behave in an entirely different way. As part of the "Thyroid Cancer Cells in Space" project by the University of Magdeburg, smartphone-sized containers carrying poorly differentiated thyroid cancer cells are sent into space.
22/02/2018International team of scientists led by Roderic Guigó at the Centre for Genomic Regulation in Barcelona showed that changes in gene expression in different tissues triggered by death can be used to predict the time of death of an individual.
21/02/2018More than 30 million Americans suffer from osteoarthritis making it one of the most common age-related diseases.
20/02/2018The field of biomimetics offers an innovative approach to solving human problems by imitating strategies found in nature. Medical research could also benefit from biomimetics, as a group of international experts from various fields, including a wildlife veterinarian and wildlife ecologists from Vetmeduni Vienna, point out using the example of chronic kidney disease.
20/02/2018The brain mechanisms of basic emotions such as anger and happiness are fairly similar across people. Differences are greater in social emotions, such as gratitude and contempt.
19/02/2018Amyloid beta pathology - protein deposits in the brain - might have been transmitted by contaminated neurosurgical instruments, suggests a new UCL-led study.
19/02/2018In a recent study, a research group at MedUni Vienna has published further details about the function of an enigmatic protein. The biological necessity of this protein, which can chemically alter certain building blocks of the genetic information, has been debated for quite a while.
16/02/2018Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
15/02/2018About 15 million Americans don't have a typical nine-to-five workday, and many of these - nurses, firefighters and flight attendants, among many other professions - may see their schedule change drastically one week to the next.
14/02/2018Scientists at the University of Delaware and the University of Illinois at Chicago have found a new way to kill liver cancer cells and inhibit tumor growth. First, they silence a key cellular enzyme, and then they add a powerful drug. They describe their methods in a new paper published in Nature Communications.
09/02/2018Researchers at the Institute of Industrial Science (IIS), the University of Tokyo, CNRS and INSERM, report a new organ-on-a-chip technology for the study of blood vessel formation and drugs targeting this event.
09/02/2018Researchers have identified a key process that enables the Ebola virus to infect host cells, providing a novel target for developing antiviral drugs.
08/02/2018Super-resolution microscopy reveals fine detail of cellular mesh underlying cell membrane.
08/02/2018Indiana University researchers have made an important step forward in the design of drugs that fight the hepatitis B virus, which can cause liver failure and liver cancer.
07/02/2018Human papilloma virus (HPV), the culprit behind cervical cancer and some forms of head and neck cancer may hide in small pockets on the surface of tonsils in people not known to carry the virus.
07/02/2018Scientists from the University of Zurich have redesigned an adenovirus for use in cancer therapy. To achieve this they developed a new protein shield that hides the virus and protects it from being eliminated. Adapters on the surface of the virus enable the reconstructed virus to specifically infect tumor cells.
06/02/2018A new study conducted by Ohio University scientists suggests that a little more sunlight might help restore damage to your cardiovascular system.
06/02/2018In the biennial mammography screening programme, the most frequent diagnosis of breast cancer in its preliminary stages is, biologically, the most aggressive form. High-grade ductal carcinoma in situ holds the greatest risk of developing into a so-called invasive carcinoma.
05/02/2018CHOP researchers find outcomes are similar, but broader-spectrum antibiotics have higher risk of adverse effects.
02/02/2018In both cell cultures and mouse models, a drug used to treat Hepatitis C effectively protected and rescued neural cells infected by the Zika virus - and blocked transmission of the virus to mouse fetuses.
01/02/2018A person needs immune-suppressive drugs for organ transplants but not typically for transplants in the eye. How come? Like a few other parts of the body, some components of the eye, like the lens, don't have direct access to vessels that deliver immune cells. They were assumed to be places that immune cells couldn't go. They were immune privileged.
31/01/2018Screening a class of recently-developed drug compounds, so-called CDK inhibitors capable of blocking CDK7/12/13 proteins, against hundreds of different human cancer cell lines, researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center have found that CDK12 inhibitors pack a particularly lethal punch to Ewing sarcoma, a rare cancer typically affecting children and young adults.
31/01/2018In a new study, published in Cell Reports, researchers from the William Harvey Research Institute at Queen Mary University of London used cells derived from urine to take the first step in generating an artificial adrenal gland.
30/01/2018Achievement in the field of cancer research: Biologists and chemists at the University of Konstanz decipher a molecular mechanism of the cell with relevance for the development of cancer and the fight against that disease. Particularly important is the interaction between the tumour-suppressor protein p53, known as the guardian of the genome, and the enzyme PARP-1, the caretaker of the genome.
29/01/2018Researchers at the Université libre de Bruxelles and University of Cambridge identified the role of key gene Mesp1 in the earliest step of cardiovascular lineage segregation. This discovery may help to better understand congenital heart defects.
29/01/2018Nerve cells in the skin help wounds to heal. When an injury occurs, cells known as glial cells change into repair cells and disseminate into the wound, where they help the skin to regenerate, researchers from the University of Zurich have shown.
26/01/2018Researchers have developed a universal vaccine to combat influenza A viruses that produces long-lasting immunity in mice and protects them against the limitations of seasonal flu vaccines, according to a study led by Georgia State University.
26/01/2018Enhanced lifestyle counselling prevents cognitive decline even in people who are carriers of the APOE4 gene, a common risk factor of Alzheimer's disease, according to a new study published in JAMA Neurology.
25/01/2018An international research team has conducted successful phase II clinical tests of a new anti-malaria medication. The treatment led to a cure in 83 cases. The new combination of drugs was developed by Professor Peter Kremsner of the Tübingen Institute of Tropical Medicine and the company DMG Deutschen Malaria GmbH.
25/01/2018Researchers have long wondered how our cells navigate inside the body. Two new studies, in which Lund University researcher Pontus Nordenfelt has participated, have now demonstrated that the cells use molecular force from within to steer themselves in a certain direction. This knowledge may be of great significance in the development of new drugs.
24/01/2018Data collected during a long-term health study provides additional evidence for a link between increased risk of cancer in individuals with advanced gum disease.
24/01/2018Down's syndrome – also known as trisomy 21 – is a genetic disorder caused by an additional third chromosome 21. Although this genetic abnormality is found in one out of 700 births, only 20% of foetuses with trisomy 21 reach full term. But how do they manage to survive the first trimester of pregnancy despite this heavy handicap?
23/01/2018For the first time, researchers have described atom-by-atom changes in a family of proteins linked to amyotrophic lateral sclerosis (ALS), a group of brain disorders known as frontotemporal dementia and degenerative diseases of muscle and bone. Their findings appear in the journal "Molecular Cell".
22/01/2018Study finds abnormalities and decreased oxygen levels in placenta during fetal development.
22/01/2018Insights may inform wound management techniques.
19/01/2018Osaka University study identifies antibody that alleviates symptoms in neuromyelitis optica in rats.
19/01/2018Around 400 million people world-wide suffer in some form or other from a grass pollen allergy (rhinitis) – with the usual symptoms such as a runny nose, cough and severe breathing problems.
18/01/2018A paper just published in "Nature Biotechnology" outlines a pioneering method of screening a person's diverse set of antibodies for rapid therapeutic discovery. Antibody proteins are an important part of the human immune system that specifically target foreign viruses and bacteria, and they have been the fastest-growing class of approved drugs in the past several decades.
17/01/2018A team of scientists led by Darío Acuña-Castroviejo, professor at the University of Granada (UGR), has published the results of a new breakthrough in molecular mechanisms of the anti-parkinsonian activity of melatonin.
12/01/2018Virus hides in plain sight by being less aggressive.
12/01/2018Psychologists reveal neural underpinnings of trypophobia.
11/01/2018An old drug supercharged by University of Queensland researchers has emerged as a new antibiotic that could destroy some of the world's most dangerous superbugs.
11/01/2018Researchers have identified several new genes responsible for Alzheimer's disease (AD) including those leading to functional and structural changes in the brain and elevated levels of AD proteins in cerebrospinal fluid (CSF).
10/01/2018Newly described stretches of super-silenced DNA reveal a fresh approach to reprogram cell identity to use in regenerative medicine studies and one day in the clinic, according to a study in Molecular Cell last week by investigators from the Perelman School of Medicine at the University of Pennsylvania.
08/01/2018Few patients with heart failure are fortunate enough to receive a donor's heart. Ventricular assist devices (or heart pumps) have been around for several years and are designed to buy time as patients wait for a transplant. Unfortunately, the body doesn't always tolerate these devices.
08/01/2018Researchers at Indiana University School of Medicine have successfully developed a method to grow hairy skin from mouse pluripotent stem cells-a discovery that could lead to new approaches to model disease and new therapies for the treatment of skin disorders and cancers.
05/01/2018A group of researchers at Osaka University developed a synthetic tissue using synovium-derived mesenchymal stem cells (MSCs) for treating damaged cartilage, which had previously been incurable and had no effective therapies.
05/01/2018Scientists at Helmholtz Zentrum München have discovered a mechanism that amplifies the autoimmune reaction in an early stage of pancreatic islet autoimmunity prior to the progression to clinical type 1 diabetes. If the researchers blocked the corresponding molecules, the immune system was significantly less active.
04/01/2018Hokkaido University researchers have uncovered a cellular protein that stabilizes a tumor promoting signaling pathway, suggesting a new target to treat prostate cancer.
22/12/2017Scientists at IST Austria and in Paris develop framework connecting and extending previous theories on how neurons in our sensory systems select and transmit information.
22/12/2017The antidepressant clomipramine may also alleviate symptoms of multiple sclerosis (MS), specifically in its progressive form, i.e. when it occurs without relapses or remissions. As yet, drugs for this type of MS have been virtually non-existent.
21/12/2017By attaching specialised molecules to the backbone of DNA, researchers have made it easier to detect rare molecules associated with early disease.
21/12/2017Dementia affects millions of people worldwide, robbing them of their ability to think, remember and live as they once did. In the search for new ways to fight cognitive decline, scientists report in ACS' Journal of Agricultural and Food Chemistry that blueberry vinegar might offer some help.
20/12/2017A new study suggests that noise sensitivity can be seen in the grey matter volume of brain structures linked to emotional and interoceptive processing.
19/12/2017A "cure" for haemophilia is one step closer, following results of a groundbreaking gene therapy trial led by the NHS in London.
19/12/2017A new study led by scientists at the University of Southampton has found that inherited variation in a particular gene may be to blame for the lower survival rate of patients diagnosed with early-onset breast cancer.
18/12/2017An antibiotic candidate compound shelved in the 1970s in favour of more worthwhile drugs could be worth a second look, new research has found.
15/12/2017Lipid, also known as fat, is an optimal energy source and an important cell component. Much is required for the rapid and uncontrolled growth of cancer cells.
15/12/2017Amniotic fluid, the protective liquid surrounding an unborn baby, is discarded as medical waste during caesarean section deliveries. However, there is increasing evidence that this fluid is a source of valuable biological material, including stem cells with the potential for use in cell therapy and regenerative medicine.
14/12/2017DNA sequences between mitochondria within a single cell are vastly different, found researchers in the Perelman School of Medicine at the University of Pennsylvania.
13/12/2017Xenon gas was studied at the Intensive Care Unit (ICU) of Turku University Hospital, Finland in 2009–2014 as a treatment for minimising the damage of cardiac arrest, and now it enters drug development in spring 2018. NeuroproteXeon is advancing the study of xenon in a pivotal phase III trial.
08/12/2017Scientists have previously shown that a parasite from cats can infect people's brain and affect our behaviour. Now, researchers at Stockholm University have discovered how the parasite takes control of our cells.
05/12/2017New study explains what happens when the immune system ages.
04/12/2017Scientists at the Universities of Birmingham and Amsterdam hope to have found a new neurobiological marker to help recognise patients with post-traumatic stress disorder (PTSD).
04/12/2017Researchers at NYU Langone Health's Perlmutter Cancer Center report that at least three kinds of bacteria in the mouths of Americans may heighten or lower their risk of developing esophageal cancer.
29/11/2017A research group at Lund University in Sweden has found that when the HLF (hepatic leukemia factor) gene –which is expressed in immature blood cells – does not shut down on time, we are unable to develop a functional long-term immune system. This could be a very early stage of leukemia.
29/11/2017During differentiation of pluripotent stem cells to cardiomyocytes, the three-dimensional folding of the DNA reorganizes itself. This reorganization of the DNA architecture precedes and defines important epigenetic patterns.
28/11/2017Differences in intelligence have so far mostly been attributed to differences in specific brain regions. However, are smart people's brains also wired differently to those of less intelligent persons? A new study published by researchers from Goethe University Frankfurt (Germany) supports this assumption.
28/11/2017A team of bioengineers and bioinformaticians at the University of California San Diego have discovered how the environment surrounding a tumor can trigger metastatic behavior in cancer cells. Specifically, when tumor cells are confined in a dense environment, the researchers found that they turn on a specific set of genes and begin to form structures that resemble blood vessels.
27/11/2017A team of scientists led by the University of Southampton has taken an important step forward in research efforts that could one day lead to an effective vaccine against the world's deadliest infectious disease.
22/08/2017Physics has always supported medical science, especially when it comes to practical implementation. Now physicists and health professionals join in collaborative research at an interdisciplinary Center in Erlangen and incorporate fundamental principles of theoretical physics in their studies of diseases.
01/08/2017Many therapeutic drugs are very powerful, but they are also very toxic at the same time. Thus, they have to be measured regularly, again and again, so that an adjustment of the individual drug dosage can be made. Until now, the "normal" way was to take the blood sample, send it to a central laboratory and get the results after some days. A new point-of-care test can measure it in 15 minutes.
03/07/2017Precision work is absolutely essential in eye surgery since the surgical site is very minute and sensitive. This is why eye surgeons have been using lasers for years. Femtosecond lasers are especially well suited to serve this purpose because they are able to cut tissue with great precision and little energy, which prevents unwanted side effects of surgery.
08/12/2016Watching millions of neurons in the brain interacting with each other – for a long time this was possible only to a limited extent. The current techniques can visualize only superficial layers or the imaging they use is too slow. But now, Prof Daniel Razansky and his team have found a new method to visualize the brain activity – by using optoacoustics.
08/08/2016What happens when stem cells differentiate? What molecular characteristics do they have? Questions that can now be easier answered with the help of a new open-source software. We spoke with Prof. Fabian Theis at the Helmholtz Center Munich, who participated in the software development.
22/07/2016Millions of people all over the world suffer from partial blindness – caused by glaucoma, a stroke or traumatic brain injury. For years, the loss of vision was deemed irreversible. But now a new treatment makes it possible to improve eyesight and vision.
09/02/2016Many people suffer from atherosclerosis, especially in developed countries. The buildup of fatty deposits inside the arterial blood vessels leads to strokes and heart attacks. Now, a new method is designed to get to the root of the problem, and with the help of nanoparticles inject new turbo replacement cells into the blood vessels which are intended to exert their curative effect.
01/02/2016Self-healing powers like a superhero on the big screen? That’s the aim of regenerative medicine; at least in a very broad sense. This promising field of biomedicine is currently highly dynamic with innovative technologies and development. New methods are designed to help propel medicine into a whole new sphere.
01/02/2016Children, especially newborns, are generally no longer simply considered to be small adults whose treatment just needs to be "reduced". This is why a pediatrician’s education includes several specialties because ultimately everything in terms of care comes together here.
01/10/2015Semiconductor nanoparticles for biomedical applications have been researched for some time now. Not only are they millionths of a millimeter in size, they also offer great potential for cancer diagnostics and therapy, so-called theranostics. They enter cells, are activated by ultrasonic radiation and destroy the cells using the generated vibration.
02/03/2015Crises come in many shapes and sizes. Whether it’s poor hygiene, thefts or treatment errors – once the crisis has arrived, things need to move quickly. For hospitals in particular, the right crisis communication is key. Yet many medical facilities still neglect the fact that crisis communication starts before the actual crisis takes place.
02/02/2015The digitization of medicine moves on. Researchers, physicians and patients equally benefit from this development – thanks to improved diagnostics with highly sensitive devices, today findings can be comprehensively analyzed and treatment decisions made on a broadened basis. Digitization also offers the area of pathology interesting fields of application.
05/01/2015T-cells are the guardians of our immune system. When they show changes, it can lead to severe inflammatory responses in the body. It is believed that the T-cells in persons who are affected by inflammatory bowel disease don’t work properly. Two proteins that can be found on activated T-cells and that interact with each other are now being analyzed.
03/11/2014The treatment of chronic wounds is extremely problematic. Chronic wounds can take months or years to heal and some even never heal resulting in over 100.000 amputations taking place annually in the US alone. A new technology from Iceland, that is based on fish skin and is already used clinically, allows for improved healing of chronic and burn wounds.
03/11/2014As an imaging procedure, magnetic resonance tomography has become essential in clinical practice, since it can easily make organs and tissue visible. However, until now abnormal cancer cells or small centers of inflammation remained almost invisible. Now cell biologists from Berlin, Germany, have succeeded in fixing this problem with xenon magnetic resonance imaging.
01/10/2014On November 10, 2014, astronaut Alexander Gerst will return to Earth from the International Space Station (ISS). He is not just anxiously expected by his family, but also by Dr. Anna-Maria Liphardt from the Institute of Biomechanics and Orthopedics at the German Sport University Cologne
01/07/2014Large burns require skin grafting. Surgeons remove split-thickness skin grafts and apply them to the injured areas. Now skin that has been made in a laboratory is meant to help in covering burns as well as chronic wounds and thus promote the healing process. Researchers in Zurich have been working on this for more than 13 years.
01/07/2014In patients with Parkinson's, neural cells in the brain die off that produce the neurotransmitter dopamine. Certain physical symptoms that can indicate the disease follow years later. But a reliable diagnosis can only be made through examination of the brain after the patient's death, and not during his lifetime.
01/07/2014The not so popular “love handles“ could revolutionize medicine in the near future. In cooperation with the University of Rostock (Professor Hermann Seitz), the human med AG Company currently seeks to develop a device that is able to gently remove adipose tissue during surgery and subsequently isolate stem cells.
10/02/2014Prof. Joachim Heberle from the Free University of Berlin wants to make the smallest protein structures visible under the microscope. He wants to accomplish this with an infrared microscope, originating in the field of physics. He told MEDICA.de which technology is behind all this and what he also wants to examine with it in the future.
03/02/2014Differentiating tumor tissue from healthy tissue isn’t always easy for surgeons. Scattered cancer cells and early cancer are often hard to detect with the naked eye. A special camera now makes even the tiniest remainder of a tumor visible during surgery.
22/01/2014It guards the body but can become its enemy: the immune system defends us from intruding pathogens; it is also able to cause severe diseases if it falsely recognizes the body itself as a threat. Molecular receptors in the whole body enable the immune system to “sense” what happens within.