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Antibody function may help keep tuberculosis infection under control


A study led by investigators from the Ragon Institute of MGH, MIT and Harvard finds evidence that antibody protection may help control infection with the bacteria that causes tuberculosis (TB).
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Computational method identifies existing drugs with virus-fighting potential


A new, computer-based screening method could reveal the virus-fighting potential of drugs originally developed to treat other conditions, reports a study in PLOS Computational Biology.
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Protein in mosquito spit can keep Dengue virus in check


Mosquito saliva influences transmission of viruses to a bitten mammalian host. For example, it contains factors that dampen the host immune response and so facilitate infection. A study published in PLOS NTDs reports on a saliva protein with the opposite effect.
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Increased risk of pneumococcal pneumonia with hospital admission


A study shows that adults admitted to hospital during school holidays are 38 percent more likely to have pneumococcal community-acquired pneumonia (CAP) than those admitted during term time.
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New model improves prediction of outbreaks of Ebola and Lassa fever


Potential outbreaks of diseases such as Ebola and Lassa fever may be more accurately predicted thanks to a new mathematical model developed by researchers at the University of Cambridge. This could in turn help inform public health messages to prevent outbreaks spreading more widely.
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Protein could open door to new class of antibiotics


Researchers have made the first-ever detailed, atomic-level images of a peroxiredoxin, which has revealed a peculiar characteristic of this protein and might form the foundation for a new approach to antibiotics.
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People with type O blood more likely to die of cholera


People with blood type O often get more severely ill from cholera than people of other blood types. New research from Washington University School of Medicine in St. Louis may explain why.
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Image: An x-ray picture of a lung showing signs of tuberculosis; Copyright: Martin Fally

Number of tuberculosis cases in India is double current estimates


The number of cases of tuberculosis (TB) in India may be up to two to three times higher than current estimates, suggests a new study.
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Yale study identifies how Zika virus infects the placenta


In a new study, Yale researchers demonstrate Zika virus infection of cells derived from human placentas. The research provides insight into how Zika virus may be transmitted from expectant mother to fetus, resulting in infection of the fetal brain. The study was published online in JCI Insight.
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New maths to predict dangerous hospital epidemics


Mathematicians are now developing completely new statistical calculations on the world’s fastest computers in order to be able to predict how epidemics of dangerous hospital bacteria spread. Studying the entire genomes of bacteria has now thrown open entirely new possibilities for revealing their secrets. It is this genetic knowledge that scientists use to understand bacterial epidemics.
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Rapid bacterial infection test reduces antibiotic use


Researchers from the Oxford University Clinical Research Unit in Vietnam have shown that using a rapid (5-minute) test can reduce antibiotic misuse for respiratory infections. Cutting the number of unnecessary antibiotic prescriptions is a key way to prevent the spread of antibiotic-resistant infections.
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Gram-negative bacteria pose a major challenge for hospitals


Every day, people are admitted to the hospital, discharged or they visit patients. This large number of people increases the risk of bacteria transmission. Preventative measures such as short-sleeved uniforms and copper surfaces can help by improving hospital hygiene but they cannot replace the legal requirements for hygiene measures.
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Textiles used in hospitals and medical offices – germs don’t stand a chance


Some hospitals have long banned the status symbol of physicians – the white coat. Research has shown that especially the sleeves were contaminated with various types of bacteria. But it’s not just lab coats that can spread germs in healthcare settings. This field uses a variety of different textiles. Wouldn’t it, therefore, make sense to apply antimicrobial finishes?
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Point-of-care-testing: from disc to diagnosis


Easy solutions that deliver results quickly are a great asset in medicine: patients receive their diagnosis faster and physicians have more time to treat them. Such tools also work without sophisticated resources and trained personal. A device currently developed in a project funded by the European Commission could bring all of this to point-of-care-testing for infectious diseases.
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Filling bone defects – replacement tissue with its own blood supply


First grow tissue in the lab, then insert it into patients when they need it and you’re done! Unfortunately, things are not as easy as people hoped at the onset of “tissue engineering”. Although robust tissues for bone defects can be grown in a petri dish, for example, they unfortunately quickly die off again inside the body if there is no corresponding nutrient supply.
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Disaster medicine or disastrous medicine?


Most Europeans think it was a long time ago, but the residents of West Africa clearly feel the consequences of the Ebola epidemic that broke out in December 2013 and still continues today. So far, approximately 11,300 people have died as a result of the outbreak; more than 28,000 contracted the disease.
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Ebola: detection strips instead of lab tests


When infectious diseases such as Ebola break out, a rapid diagnosis is important because the early detection of a virus along with the right hygiene measures can prevent its continued spread. However, laboratories and skilled personnel are not available everywhere. Low-cost and portable detection strips can bring relief.
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Rapid Tests: valuable helpers for use in the field


Infectious diseases are widespread in conflict areas. When basic medical care is lacking on location, people cannot be appropriately treated. Laboratory tests are limited in the field. Rapid diagnostic tests make it possible for medical personnel to quickly and accurately test patients for several infectious diseases, for instance for the presence of malaria or HIV infection.
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Hospitals: many small measures against infections and sepsis


If neither the immune system nor antibiotics are able to control an infection, a sepsis can arise out of it - an infection that attacks several organs at the same time and causes the immune system to overreact. This is a life-threatening condition.
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Hygiene: "The sensor applies the principle of so-called photonic structures"


Detecting infections quickly and reliably with the naked eye: This is what many doctors in hospitals and in the doctor's surgeries wish for. To make this dream come true, Prof. Holger Schönherr, a scientist from Siegen, is researching a sensor that should show an infection by a color change.
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Multi-resistant bacteria want to conquer the world


Bacteria lurk everywhere: on the skin, in the intestines and in every puddle. Most of them that are hanging out in the human body are good bacteria. But not all of them. Those pathogens that exhibit resistance and are thus very hard to combat are the most dangerous kind. Their spread threatens people all over the world.
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"The immunosensory system goes beyond the actual immune cells"


It guards the body but can become its enemy: the immune system defends us from intruding pathogens; it is also able to cause severe diseases if it falsely recognizes the body itself as a threat. Molecular receptors in the whole body enable the immune system to “sense” what happens within.
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"The Virus Manipulates the Host Cell on Different Levels"


Heart diseases can be triggered by special viruses that affect the cardiac muscle. Preventive drugs could definitely be developed – if the virus does not mutate.
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