Image: Immunohistochemical staining of nasal polyp tissue; Copyright: Helmholtz Zentrum München

Response to house dust mites is age-dependent

31/08/2016

In adults with a house dust mite allergy, a cascade of inflammatory signals on the surface of the airways leads to airway remodeling. This process cannot be influenced by standard cortisone therapy. Researchers at Helmholtz Zentrum München and the Technical University of Munich have reported these findings.
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Image: Green OLED light during physical stimulation of cells (OLED and cell culture plate); Copyright: Fraunhofer FEP

Cell-compatible OLEDs for use with patients

29/08/2016

Cytocompatibility studies of organic light-emitting diodes (OLEDs) have been carried out on cell cultures for the first time at the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP to test how well OLEDs are tolerated by cells.
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Image: Two pictures of a mouse model of Alzheimer's disease; Copyright: Salk Institute

Elevating brain protein allays symptoms of Alzheimer's

26/08/2016

Boosting levels of a specific protein in the brain alleviates hallmark features of Alzheimer's disease in a mouse model of the disorder, according to new research published online in "Scientific Reports".
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Image: Green insect cells under seen through a microsope; Copyright: Helmholtz Zentrum München

Progress in vaccination against vespid venom

25/08/2016

Especially in late summer, apprehension about wasp stings increases amongst allergy sufferers. So-called hyposensibilisation therapy can help, but it is linked to a heavy burden on patients and health insurers. Researchers at the Helmholtz Zentrum München and the Technical University Munich have now presented a method in the journal "Allergy", which facilitates a personalised procedure.
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Image: Fluorescence microscopy image of stem cells; Copyright: Aalto University

Nanofiber scaffolds show new behaviour of stem and cancer cells

24/08/2016

A discovery in the field of biomaterials may open new frontiers in stem and cancer cell manipulation and associated advanced therapy development. Novel scaffolds are shown enabling cells to behave in a different but controlled way in vitro due to the presence of aligned, self-assembled ceramic nanofibers of an ultra-high anisotropy ratio augmented into graphene shells.
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Image: Pictured is a fluorescently labeled endothelial cell monolayer, pseudocolorized in blue/green; Copyright: University of Pittsburgh

Gene therapy via ultrasound could offer new therapeutic tool

23/08/2016

Combining ultrasound energy and microbubbles to poke holes in cells may prove to be a new tool in the fight against cardiovascular disease and cancer, according to researchers from the University of Pittsburgh and UPMC. A study on this gene therapy approach, called sonoporation, is published in the Proceedings of the National Academy of Sciences (PNAS).
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Image: 3D-image of a person, in the esophagus is one part highlighted red; Copyright: Panthermdia.net/Eraxion

Bad or benign? Testing cells for esophageal cancer risk

22/08/2016

Genetically analysing lesions in the food pipe could provide an early and accurate test for oesophageal cancer, according to research led by Queen Mary University of London (QMUL), Academic Medical Center in Amsterdam and Arizona State University.
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Image: Computer generated image showing round orange cells; Copyright: panthermedia.net/knorre

Online marketing of stem cell therapy

09/08/2016

Advanced economy nations led by Ireland, Singapore, Australia, Germany, Italy, Japan, and the United States have the highest per capita number of clinics engaging in direct-to-consumer marketing of stem cell therapies, according to the world's largest-ever study of such clinics.
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Image: User interface of a software; Copyright: Helmholtz Zentrum München

Cell under observation: "The software lets us study the development on video"

08/08/2016

What happens when stem cells differentiate? What molecular characteristics do they have? Questions that can now be easier answered with the help of a new open-source software. We spoke with Prof. Fabian Theis at the Helmholtz Center Munich, who participated in the software development.
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Image: design of nanocarriers; Copyright: University of Pennsylvania

Penn researchers improve computer modeling for designing drug-delivery nanocarriers

05/08/2016

Researchers has developed a computer model that will aid in the design of nanocarriers, microscopic structures used to guide drugs to their targets in the body. The model better accounts for how the surfaces of different types of cells undulate due to thermal fluctuations, informing features of the nanocarriers that will help them stick to cells long enough to deliver their payloads.
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Image: Depiction of patch sensor via CFDRC; Copyright: Sergio Omar Garcia/CFDRC

Sustainable sensors to detect, predict muscle fatigue

02/08/2016

It may be clammy and inconvenient, but human sweat has at least one positive characteristic - it can give insight to what is happening inside your body.
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Image: Enlarged neurons. The cell bodies are purple, whereas the axons are green; Copyright: UAB

Discovery may lead to a treatment to slow Parkinson's disease

22/07/2016

Using a robust model for Parkinson's disease, University of Alabama at Birmingham researchers and colleagues have discovered an interaction in neurons that contributes to Parkinson's disease, and they have shown that drugs now under development may block the process.
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Image: Closed eyes of a patient. Electrodes are attached above the eyebrows; Copyright: savir-center.com

Electrical Stimulation: Using Electrical Pulses to Combat Blindness

22/07/2016

Millions of people all over the world suffer from partial blindness – caused by glaucoma, a stroke or traumatic brain injury. For years, the loss of vision was deemed irreversible. But now a new treatment makes it possible to improve eyesight and vision.
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Image: A man and a woman sitting at a table, looking into the camera. There are papers and a monitor on the table; Copyright: Universitat Jaume I de Castellón

Researchers discover genetic causes of higher melanoma risk in men

22/07/2016

A study led by researchers at Universitat Jaume I de Castellón has identified one of the genetic causes underlying the higher rate of melanoma in men. The results have been published in Biology of Sex Differences.
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Image: Microscopy image of a culture mouse neuron; Copyright: Carlos Sánchez-Huertas

The machinery that neurons use to form and maintain their neuronal extensions

22/07/2016

The study, led by IRB Barcelona and published in Nature Communications will help research into regenerative medicine and potentially also help understand neurodegenerative diseases such as Alzheimer’s.
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Image: An upper half body, which is blue and transparent. The muscles of the arm are higlighted in red; Copyright: panthermedia.net/Eraxion

Protein found to bolster growth of damaged muscle tissue

21/07/2016

Johns Hopkins University biologists have found that a protein that plays a key role in the lives of stem cells can bolster the growth of damaged muscle tissue, a step that could potentially contribute to treatments for muscle degeneration caused by old age and diseases such as muscular dystrophy.
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Image: Graphic of a neuron, that is connected with many other neurons via synapses. The synapses are glowing at several points; Copyright: panthermedia.net/ktsdesign

World Brain Day 2016 - The ageing brain

21/07/2016

The World Federation of Neurology (WFN) invites the people to observe the World Brain Day for the third time in 2016. This year’s motto is “The ageing brain”. The focus lies on prevention of and dealing with the neurological diseases stroke, Alzheimer’s disease and Parkinson’s disease, since the risk to fall ill with them increases with age.
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Image: Three microfluidic devices made from transparent plastic; Copyright: SMART

Microfluidic device to study electric field cancer therapy

14/07/2016

Researchers at MIT's research center in Singapore have developed a new microfluidic device that tests the effects of electric fields on cancer cells. They observed that a range of low-intensity, middle-frequency electric fields effectively stopped breast and lung cancer cells from growing and spreading, while having no adverse effect on neighboring healthy cells.
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Photo: A coloured tissue section with makred cancer cells

Consensus in the fight against colorectal cancer

07/07/2016

In colorectal cancer, the presence of invasive tumor cells at the advancing edge of the tumor can provide valuable information on prognosis. Initiated by the Colorectal Cancer Research Group at the Institute of Pathology, University of Bern, a consensus conference was held to determine how this phenomenon should best be put into practice.
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Photo: A plug of pink 3-D bioprinted cartilage on top of a plug of osteocondral material

3-D printing produces cartilage from strands of bioink

28/06/2016

Strands of cow cartilage substitute for ink in a 3D bioprinting process that may one day create cartilage patches for worn out joints, according to a team of engineers.
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Photo: petri dish next to further samples

Software improves ability to catalog bacterial pathogens

28/06/2016

Washington State University researchers have developed a new software tool that will improve scientists' ability to identify and understand bacterial strains and accelerate vaccine development.
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Photo: syringe and stethoscope lay on a paper with the word

New approach to determining risk of cancer reoccurring

27/06/2016

What is the likelihood of a patient developing cancer again after having a tumor removed? This is the question that experts in medicine and medical informatics at Friedrich-Alexander Universität Erlangen-Nürnberg (FAU) aim to find answers to in a new research project called ‘MelEVIR – Melanoma, Extracellular Vesicles and Immune Response’.
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Photo: syringe and stethoscope lay on a paper with the word

A better way to predict diabetes

24/06/2016

Researchers have discovered a simple, accurate new way to predict which women with gestational diabetes will develop type 2 diabetes after delivery. The discovery would allow health care providers to identify women at greatest risk and help motivate women to make early lifestyle changes and follow other strategies that could prevent them from developing the disease later in life.
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Graphic: printer prints a human head

A new bio-ink for 3-D printing with stem cells

24/06/2016

The new stem cell-containing bio ink allows 3D printing of living tissue, known as bio-printing. The new bio-ink contains two different polymer components: a natural polymer extracted from seaweed, and a sacrificial synthetic polymer used in the medical industry, and both had a role to play.
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Photo: blood cells under a microscope

Fighting resistant blood cancer cells

22/06/2016

Chronic myeloid leukemia (CML) develops through chromosomal alterations in blood-forming cells of the bone marrow and usually occurs in older persons. Around 20 percent of adults diagnosed with leukemia suffer from this type of blood cancer.
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Photo: a woman smokes an e-cigarette

E-cigarette: hundreds of genes involved in airway immune defense

21/06/2016

When we smoke cigarettes, dozens of genes important for immune defense are altered in the epithelial cells that line the respiratory tract. Several of these changes likely increase the risk of bacterial infections, viruses, and inflammation. Now, electronic cigarettes alters those same genes and hundreds more that are important for immune defense in the upper airway.
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Photo: Phil Santangelo and Eric Alonas are shown with a spinning disk confocal microscope used to image cells

Tiny mirror improves microscope resolution for studying cells

17/06/2016

A tiny mirror could make a huge difference for scientists trying to understand what's happening in the micron-scale structures of living cells.
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Photo: T-cells under a microscope

Super-resolution microscopy reveals unprecedented detail of immune cells' surface

16/06/2016

hen the body is fighting an invading pathogen, white blood cells including T-cells must respond. Now, Salk Institute researchers have imaged how vital receptors on the surface of T cells bundle together when activated.
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Photo: cancer cells

Antibody-based drug helps 'bridge' leukemia patients to curative treatment

14/06/2016

In a randomized Phase III study of the drug inotuzumab ozogamicin, a statistically significant percentage of patients with acute lymphoblastic leukemia (ALL) whose disease had relapsed following standard therapies, qualified for stem cell transplants.
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Photo: blood sample

Blood test could help monitor treatment response

13/06/2016

Scientists at the German Center for Neurodegenerative Diseases (DZNE), the Hertie Institute for Clinical Brain Research and the University of Tübingen have identified proteins in the blood and cerebrospinal fluid that reflect nerve cell damage.
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Photo: A tissue sample coloured in red and green

New way of growing blood vessels for regenerative medicine

02/06/2016

Growing tissues and organs in the lab for transplantation into patients could become easier after scientists discovered an effective way to produce three-dimensional networks of blood vessels, vital for tissue survival yet a current stumbling block in regenerative medicine.
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Photo: two physicians working at a test set-up

Atherosclerosis: Getting to the root of the problem with a turbo gene

09/02/2016

Many people suffer from atherosclerosis, especially in developed countries. The buildup of fatty deposits inside the arterial blood vessels leads to strokes and heart attacks. Now, a new method is designed to get to the root of the problem, and with the help of nanoparticles inject new turbo replacement cells into the blood vessels which are intended to exert their curative effect.
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Photo: child with broken arm

Different specialties, one goal – treating children right

01/02/2016

Children, especially newborns, are generally no longer simply considered to be small adults whose treatment just needs to be "reduced". This is why a pediatrician’s education includes several specialties because ultimately everything in terms of care comes together here.
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Photo: pipette in petri dish

Great leaps forward thanks to new methods

01/02/2016

Self-healing powers like a superhero on the big screen? That’s the aim of regenerative medicine; at least in a very broad sense. This promising field of biomedicine is currently highly dynamic with innovative technologies and development. New methods are designed to help propel medicine into a whole new sphere.
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From the periodic table of elements into medicine: silicon for theranostics

01/10/2015

Semiconductor nanoparticles for biomedical applications have been researched for some time now. Not only are they millionths of a millimeter in size, they also offer great potential for cancer diagnostics and therapy, so-called theranostics. They enter cells, are activated by ultrasonic radiation and destroy the cells using the generated vibration.
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Hospital crisis communication: A crisis knows no rules

02/03/2015

Crises come in many shapes and sizes. Whether it’s poor hygiene, thefts or treatment errors – once the crisis has arrived, things need to move quickly. For hospitals in particular, the right crisis communication is key. Yet many medical facilities still neglect the fact that crisis communication starts before the actual crisis takes place.
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Photo: Tissue sections on object slides

Digital pathology: From microscope slide to virtual microscopy

02/02/2015

The digitization of medicine moves on. Researchers, physicians and patients equally benefit from this development – thanks to improved diagnostics with highly sensitive devices, today findings can be comprehensively analyzed and treatment decisions made on a broadened basis. Digitization also offers the area of pathology interesting fields of application.
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Photo: interaction between the proteins

IBD: When genetics and environment interact

05/01/2015

T-cells are the guardians of our immune system. When they show changes, it can lead to severe inflammatory responses in the body. It is believed that the T-cells in persons who are affected by inflammatory bowel disease don’t work properly. Two proteins that can be found on activated T-cells and that interact with each other are now being analyzed.
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Wound treatment with fish skin

03/11/2014

The treatment of chronic wounds is extremely problematic. Chronic wounds can take months or years to heal and some even never heal resulting in over 100.000 amputations taking place annually in the US alone. A new technology from Iceland, that is based on fish skin and is already used clinically, allows for improved healing of chronic and burn wounds.
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Xenon magnetic resonance imaging: making pathological changes in the body visible

03/11/2014

As an imaging procedure, magnetic resonance tomography has become essential in clinical practice, since it can easily make organs and tissue visible. However, until now abnormal cancer cells or small centers of inflammation remained almost invisible. Now cell biologists from Berlin, Germany, have succeeded in fixing this problem with xenon magnetic resonance imaging.
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Photo: Dr. Anna-Maria Liphardt

Laboratory in Space: Hot on the Trails of Cartilage Degradation

01/10/2014

On November 10, 2014, astronaut Alexander Gerst will return to Earth from the International Space Station (ISS). He is not just anxiously expected by his family, but also by Dr. Anna-Maria Liphardt from the Institute of Biomechanics and Orthopedics at the German Sport University Cologne
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Cultured skin makes large-scale transplantations possible

01/07/2014

Large burns require skin grafting. Surgeons remove split-thickness skin grafts and apply them to the injured areas. Now skin that has been made in a laboratory is meant to help in covering burns as well as chronic wounds and thus promote the healing process. Researchers in Zurich have been working on this for more than 13 years.
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Diagnosing Parkinson's: the skin is revealing

01/07/2014

In patients with Parkinson's, neural cells in the brain die off that produce the neurotransmitter dopamine. Certain physical symptoms that can indicate the disease follow years later. But a reliable diagnosis can only be made through examination of the brain after the patient's death, and not during his lifetime.
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Fat is the best medicine: "Adipose tissue contains many multipotent stem cells, approximately 500 times more than bone marrow"

01/07/2014

The not so popular “love handles“ could revolutionize medicine in the near future. In cooperation with the University of Rostock (Professor Hermann Seitz), the human med AG Company currently seeks to develop a device that is able to gently remove adipose tissue during surgery and subsequently isolate stem cells.
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"We don’t know why certain pharmaceuticals bind especially well while others bind barely at all"

10/02/2014

Prof. Joachim Heberle from the Free University of Berlin wants to make the smallest protein structures visible under the microscope. He wants to accomplish this with an infrared microscope, originating in the field of physics. He told MEDICA.de which technology is behind all this and what he also wants to examine with it in the future.
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Surgery: "Our camera detects the tiniest remainder of a tumor"

03/02/2014

Differentiating tumor tissue from healthy tissue isn’t always easy for surgeons. Scattered cancer cells and early cancer are often hard to detect with the naked eye. A special camera now makes even the tiniest remainder of a tumor visible during surgery.
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"The immunosensory system goes beyond the actual immune cells"

22/01/2014

It guards the body but can become its enemy: the immune system defends us from intruding pathogens; it is also able to cause severe diseases if it falsely recognizes the body itself as a threat. Molecular receptors in the whole body enable the immune system to “sense” what happens within.
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