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Presence of certain oral bacterium in esophageal cancer samples associated with shorter survival


Bottom Line: Among Japanese patients with esophageal cancer, those whose cancer tested positive for DNA from the bacterium Fusobacterium nucleatum had shorter cancer-specific survival compared with those whose cancer had no DNA from the bacterium.
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Tiny gold particles could be the key to developing a treatment for pancreatic cancer


A diagnosis of pancreatic cancer is often a death sentence because chemotherapy and radiation have little impact on the disease. In the U.S. this year, some 53,000 new cases will be diagnosed, and 42,000 patients will die of the disease. But research now being reported in ACS Nano could eventually lead to a new type of treatment based on gold nanoparticles.
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WSU portable smartphone laboratory detects cancer


Washington State University researchers have developed a low-cost, portable laboratory on a smartphone that can analyze several samples at once to catch a cancer biomarker, producing lab quality results.
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New advances in imaging to enhance the detection of GI cancers


A new imaging technique is under development with the aim of detecting and characterizing early cancerous changes in the gastrointestinal (GI) tract
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Thousands of melanoma patients in Europe have no access to new life saving drugs


Over 5000 patients with metastatic melanoma in Europe are denied access to new, life saving drugs every year, according to a survey presented at the ESMO 2016 Congress in Copenhagen.
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Scientists aim to slow fast growth of cancer cells


The fight against cancer is a marathon, fought step by step, inch by inch. While breakthroughs may be rare, a new study from the Faculty of Medicine & Dentistry is giving greater insight into the growth of cancer cells and bringing researchers one step closer to the finish line.
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Precision medicine trial shows benefit to patients


A clinical trial for types of advanced cancer is the first of its kind to show that precision medicine - or tailoring treatment for individual people - can slow down the time it takes for a tumor to grow back, according to research presented at the Molecular Analysis for Personalized Therapy (MAP) conference.
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Contraceptives: Deaths from ovarian cancer decline worldwide


Deaths from ovarian cancer fell worldwide between 2002 and 2012 and are predicted to continue to decline in the USA, European Union (EU) and, though to a smaller degree, in Japan by 2020, according to new research published in the leading cancer journal Annals of Oncology.
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Software helps to find out why "jumping genes" are activated


Jumping genes, so-called transposons, reproduce as parasites in the genome. This selfish behavior can be an evolutionary advantage for the organism or harm it. There is still a debate about the factors controlling the activity of transposons.
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Dying tumour cells release intracellular ions


Researchers at the National Cancer Institute in the USA and the Babraham Institute, UK, have discovered how a mineral ion leaked from tumour tissue as it dies acts to stop the work of anti-tumour immune cells. This discovery provides a new approach in the development of treatments to engage the immune system in the fight against cancer.
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Voices of patients and oncologists must be heard, study says


Specifically training oncologists and their patients to have high-quality discussions improves communication, but troubling gaps still exist between the two groups, according to a new study in "JAMA Oncology".
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Penn software helps to identify course of cancer metastasis


Individual cells within a tumor are not all the same. This may sound like a modern medical truism, but it wasn't very long ago that oncologists assumed that taking a single biopsy from a patient's tumor would be an accurate reflection of the physiological and genetic make-up of the entire mass.
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Study shows how Chinese medicine kills cancer cells


Researchers at the University of Adelaide have shown how a complex mix of plant compounds derived from ancient clinical practice in China – a Traditional Chinese Medicine – works to kill cancer cells.
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Image: Image shows blue marked ephrins and red marked ephs forming yellow marked complexes at cell contact points; Copyright: MPI of Neurobiology/Gaitanos

Hungry cells on the move


Researchers discover a signalling pathway that enables cells to reach their destinations through repulsion.
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Medication against schizophrenia inhibits pancreatic cancer


A receptor for the dopamine neurotransmitter promotes growth and spread of pancreatic cancer -- and schizophrenia drugs, which block the function of this receptor, slowed tumor growth and metastatic spread in mice, according to researchers at McGill University and the German Cancer Research Center.
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Study opens door to targeted treatments for esophageal cancer


Potential outbreaks of diseases such as Ebola and Lassa fever may be more accurately predicted thanks to a new mathematical model developed by researchers at the University of Cambridge. This could in turn help inform public health messages to prevent outbreaks spreading more widely.
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Artificial intelligence expedites breast cancer risk prediction


Researchers at Houston Methodist have developed an artificial intelligence (AI) software that reliably interprets mammograms, assisting doctors with a quick and accurate prediction of breast cancer risk.
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Image: Drawing of a rat and green tea and in the middle a heart. The green background is full of green leafs; Copyright: Kyoto University

Drinking green tea to prevent artery explosion


According to new research, green tea could prevent a deadly condition in the body's main artery. A Kyoto University team has found that abdominal aortic aneurysm - a condition in which the main artery becomes overstretched and bloated - developed less frequently in rats that drank green tea polyphenol, a major component of green tea.
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Nanofiber scaffolds show new behaviour of stem and cancer cells


A discovery in the field of biomaterials may open new frontiers in stem and cancer cell manipulation and associated advanced therapy development. Novel scaffolds are shown enabling cells to behave in a different but controlled way in vitro due to the presence of aligned, self-assembled ceramic nanofibers of an ultra-high anisotropy ratio augmented into graphene shells.
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Image: Pictured is a fluorescently labeled endothelial cell monolayer, pseudocolorized in blue/green; Copyright: University of Pittsburgh

Gene therapy via ultrasound could offer new therapeutic tool


Combining ultrasound energy and microbubbles to poke holes in cells may prove to be a new tool in the fight against cardiovascular disease and cancer, according to researchers from the University of Pittsburgh and UPMC. A study on this gene therapy approach, called sonoporation, is published in the Proceedings of the National Academy of Sciences (PNAS).
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Bad or benign? Testing cells for esophageal cancer risk


Genetically analysing lesions in the food pipe could provide an early and accurate test for oesophageal cancer, according to research led by Queen Mary University of London (QMUL), Academic Medical Center in Amsterdam and Arizona State University.
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Breast: Microbiome differences between healthy and cancerous tissue


A team of Mayo Clinic researchers has identified evidence of bacteria in sterilely-obtained breast tissue and found differences between women with and without breast cancer. The findings are published in Scientific Reports.
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Health Apps: "Mobile Applications for smartphones have strengths and weaknesses"


Medical apps like diabetes or high blood pressure diaries are becoming increasingly popular with smartphone users. There are many available choices out there but they are not always clear. Added to this is the question of how the data collected by the apps can be sensibly incorporated into treatment.
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Pancreatic cancer: diagnosis via signature analysis


Pancreatic cancer is one of the deadliest forms of cancer because it is difficult to diagnose and only presents with symptoms in the later stages. In the future, a laboratory test developed at the Greifswald University Medicine could make an early detection of this type of cancer and consequently a faster and better treatment possible.
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Esophageal cancer: increased patient safety thanks to the ”Da Vinci“ surgical system


Interview with Professor Jürgen Weitz, Director of the Clinic and Polyclinic of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus at the Technical University Dresden
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Fighting myomas with ultrasound


A proper diagnosis is a part of great therapy. However, it can also be beneficial to be able to quickly respond to changes during a treatment. One example of this is the treatment of uterine myomas. Female patients at the University Hospital Bonn are treated using so-called high-intensity focused ultrasound, HIFU in short. Prof. Holger Strunk explains this procedure.
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From the periodic table of elements into medicine: silicon for theranostics


Semiconductor nanoparticles for biomedical applications have been researched for some time now. Not only are they millionths of a millimeter in size, they also offer great potential for cancer diagnostics and therapy, so-called theranostics. They enter cells, are activated by ultrasonic radiation and destroy the cells using the generated vibration.
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Theranostics: Complex particles for tomorrow's medicine


It is a portmanteau, a mixture of two words. This way it saves us time and trouble while speaking because the human speech apparatus is lazy. And it describes a mixture of procedures: the combination of two procedures that would normally be separate in medicine. We are talking about theranostics.
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Prostate cancer: Agent with theranostic potential


Endoradiotherapy can be very unpleasant for cancer patients, since it does not only harm tumor cells, but also healthy ones. Sometimes, patients even need to stop therapy because of the side effects. Physicians and researchers are thus continuously searching for ways to transport radiopharmaceuticals directly and exclusively to their target.
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Making the invisible visible with fluorescence


Bladder tumors have different growth characteristics. In most cases, they are limited to the inner wall of the bladder and thus well resectable. Unlike carcinoma in situ, which becomes muscle invasive after a certain amount of time. To be able to completely remove the tumor during resection, photodynamic diagnostics (PDD) can make sense.
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Cancer Immunotherapy: Individual mutations as new target structures


A tumor is as unique as the person who is affected by it. For a long time, it was assumed this would make treatment more difficult since cancer drugs are not able to be one hundred percent effective in targeting the affected cells. In this interview with, Professor Ugur Sahin explains why it is precisely these individual mutations that make him hopeful for a new type of therapy.
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Lung cancer: A blood test evaluates the effectiveness of therapy


Can liquid biopsies become the new trend in cancer diagnostics? The medical world has asked this question for quite some time. The first globally approved liquid biopsy-based test for lung cancer shows that this can work. Yet further findings and research are still required to establish this less invasive method in diagnostics.
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Tumor markers: State-of-the-art diagnostics for personalized medicine


When cancer is diagnosed, the terms tumor markers or biomarkers keep popping up. They describe characteristics that are not found in healthy persons. The classic tumor markers can be easily detected in blood samples or other body fluids. Other analysis methods require more effort. Yet they all share one thing in common: biomarkers indicate a potential tumor.
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Cancer prevention: Beneficial and ultimately personal


There are many decisions to be made in an adult life; among them are cancer prevention screenings. They are voluntary and many people deliberate whether they should go or not and if they would actually want to know the results. Science, politics and health care professionals also ponder with each new preventive service whether it is beneficial and who should end up paying for it.
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Early cancer detection: "Physicians and patients need a good database"


Whether it is a mammogram, colonoscopy or a skin cancer screening – after a certain age, we are subject to various early cancer detection screenings. Yet many of us don’t know that these screening tests are also associated with risks. This is something what Dr. Sylvia Sänger from the University Medical Center Hamburg-Eppendorf discovered in a study.
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Statutory Skin Cancer Screening: "This is not just about mortality rates"


Since the end of April 2015, the long-awaited evaluation report on the skin cancer screening programs offered by German health insurance providers is now finally available. We spoke with Dr. Ralph von Kiedrowski, Board Member of the German Dermatologist Association (German: Berufsverband Deutscher Dermatologen) on what the screening can accomplish and his take on the G-BA report.
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Tissue storage: "Our top biobanks are internationally leading the charge"


Only projects with a solid foundation are successful in the long run. This is also true for science. Biobanks are the most important component of this foundation when it comes to fundamental biomedical research: Only high quality tissue samples that are stored there make conclusive research possible - for example in search of the causes of tumorigenesis.
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Xenon magnetic resonance imaging: making pathological changes in the body visible


As an imaging procedure, magnetic resonance tomography has become essential in clinical practice, since it can easily make organs and tissue visible. However, until now abnormal cancer cells or small centers of inflammation remained almost invisible. Now cell biologists from Berlin, Germany, have succeeded in fixing this problem with xenon magnetic resonance imaging.
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KOHALA: digital student for cancer treatment


Shortening a time-consuming procedure from four hours to five minutes and automate it at the same time sounds like a dream come true for employees in all fields and industry sectors. This dream could soon become a reality for radiologists. Software could take away the tedious processing of CT images, which is required before cancer radiation therapy.
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Radiology and technology: "Numerous phantom studies have been conducted that prove the advantages of this new CT system"


Radiologists usually do their work after oncologists when it comes to cancer treatment. Yet modern radiology also provides treatments at this point. spoke with Professor Stefan Schönberg, Director of the Institute of Clinical Radiology and Nuclear Medicine at the University Medical Center Mannheim, Germany, about the use of a new computer tomograph and its benefits for patients.
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Surgery: "Our camera detects the tiniest remainder of a tumor"


Differentiating tumor tissue from healthy tissue isn’t always easy for surgeons. Scattered cancer cells and early cancer are often hard to detect with the naked eye. A special camera now makes even the tiniest remainder of a tumor visible during surgery.
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Photo: Removal of a colon polyp with a snare

Endoscopy: "A small section of the colonic wall is completely removed"


Eventually, all adults need to see a physician for colon cancer prevention. While the exam goes by quickly thanks to sedation, it sometimes leads to a follow-up procedure if a growth in the colon could not be removed with the endoscope and requires open surgery.
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